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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Sulfur-grapheue composite for rechargeable lithium batteries显示文摘 | Wang J Z Lua L Choucair M | 2011 | Journal of Power Sources2011，196，16： | 1 |
| 3 | Carcinoma of the thyroglossal duct显示文摘 | Renard TH Choucair RJ Stevenson WD | 1990 | Surg Gynecol Obstet1990，171，： | 1 |
| 4 | Gram-scale Production of Graphene Based on Solvothermal Synthesis and Sonication显示文摘 | Choucair M Thordarson P Stride J A | | 0，，04： | 1 |
| 5 | Graftskin therapy in epidernolysis bullosa显示文摘 | Fivenson DP Scherschun L Choucair M | 2003 | J AM ACAD Dermatol2003，48，6： | 1 |
| 6 | Enhanced reversible lithium storage in a nanosize silieon/graphene composite 显示文摘 | S L Chou J Z Wang M Choucair | 2010 | Electrochemistry Communications2010，12，2： | 1 |
| 7 | Phase III randomized study of postradiotherapy chemotherapy with combination alphadifluoromethylor nithine PCV versus PCV for anaplastic gliomas 显示文摘 | Levin VA Hess KR Choucair A | 2003 | Clin Cancer Res2003，9，3： | 1 |
| 8 | Extended superficial musculaponeurotic system dissection and composite rhytidectomy 显示文摘 | CHOUCAIR R J HAMRA S T | 2008 | Clin Plast Surg2008，35，4： | 1 |
| 9 | Gram - scale pro- duction of graphene based on solvothermal synthesis and sonication 显示文摘 | Choucair M Thorda Pall Stride J A | 2009 | Nat Nanotechnol2009，4，1： | 1 |
| 10 | Enhanced reversible lithium storage in a nanosize silicon/graphene composite显示文摘 | CHOU S L WANG J Z CHOUCAIR M | 2010 | Electrochemistry Communications2010，12，2： | 1 |
| 11 | Gram-scale production of graphene based on solvothermal synthesis and sonication 显示文摘 | Choucair M Thordarson P Stride J A | | Nature nanotechnology0，4，： | 1 |
| 12 | Gram-scale production of graphene based on solvothermal synthesis and sonication显示文摘 | Choucair M Thordarson P Stride J A | 2009 | Nat Nanotechnol2009，4，1： | 1 |
| 13 | Control of amphiphilic block copolymer morphologies using solution conditions显示文摘 | A. Choucair A. Eisenberg | 2003 | The European Physical Journal E2003，，1： | 1 |
| 14 | Meta-analysis of antiarrhythmic therapy in the prevention of postoperative atrial fibrillarion and the effect on hospital length of stay, costs, cerebrovascular accidents, and mortality in patients undergoing caridiac surgery显示文摘 | Zimmer J Pezzullo J Choucair W | 2003 | Am J Cardiol2003，91，9： | 1 |
| 15 | Acellular alloder - mis in burns surgery: 1 - year results of a pilot trial 显示文摘 | SHERIDAN R CHOUCAIR R DONELAN M | 1998 | J Burn Care Rehabil1998，19，6： | 1 |
| 16 | Gram-scale production of graphene based on solvothermal synthesis and sonication显示文摘 | Choucair M Thordarson P Stride J A | 2009 | Nat Nanotechnol2009，4，1： | 1 |
| 17 | Adsorption and desorption characteristics of 3-dimensional networks of fiased gtaphen~ 显示文摘 | CHOUCAIR M TSE N M K HILL M R | 2012 | Surf Sci2012，606，： | 1 |
| 18 | Control of amphiphilic block copolymer morphologies using solution conditions 显示文摘 | Choucair A Eisenberg A | 2003 | Eur Phys J E2003，10，1： | 1 |
| 19 | , Gram-scale production of graphene based on solvothermal synthesis and sonieation显示文摘 | Mohammad Choucair | 2009 | Nature nano- technology2009，4，： | 1 |
| 20 | Enhanced reversible lithium storage in a nanosize silicon/graphene composite显示文摘 | Chou S L Wang J Z Choucair M | 2010 | E- lectrochemistry Communications2010，12，2： | 1 |
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