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| 1 | Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer显示文摘渗入肿瘤的 Tregs 的起源,肿瘤免疫力的抑制的批评调停人,是不清楚的。这里,,我们证明在人的乳癌的渗入肿瘤的天真的 CD4 + T 房间和 Tregs 有重叠 TCR 全部剧目几乎别与传播 Tregs 重叠,建议 intratumoral Tregs 主要在 situ 而非从招募的 Tregs 从天真的 T 房间发展。而且,许多天真的 CD4 + T 房间和 Tregs 密切被相关,两个显示的穷人为乳癌病人的预后。天真的 CD4 + T 房间与许多生产 CCL18 巨噬细胞成比例遵守肿瘤片。而且,采纳地转移的人的天真的 CD4 + T 房间以一种 CCL18 依赖的方式渗入人的乳癌 orthotopic 异种皮移植。在在人性化的鼠标的人的乳癌异种皮移植,由将 PITPNM3 的表达式击倒堵住天真的 CD4 + T 房间的招募进肿瘤, CCL18 受体,显著地减少 intratumoral Tregs 并且禁止肿瘤前进。这些调查结果建议那个乳房渗入肿瘤的 Tregs 从在 situ 区分进 Tregs 的传播天真的 CD4 + T 房间的趋化性产生。由防碍 CCL18 的 PITPNM3 识别禁止天真的 CD4 + T 房间招募进肿瘤可以是为 anticancer 免疫疗法的吸引人的策略。 | Shicheng Su Jianyou Liao Jiang Liu Di Huang Chonghua He Fei Chen LinBing Yang Wei Wu Jianing Chen Ling Lin Yunjie Zeng Nengtai Ouyang Xiuying Cui Herui Yao Fengxi Su Jian-dong Huang Judy Lieberman Qiang Liu Erwei Song | 2017 | Cell Research2017，27，4： | 19 |
| 2 | Theoretical analysis and experimental results of interference striation pattern of underwater target radiated noise in shallow water waveguide显示文摘在浅水里不变的波导是一个吸引人的话题在最近散发的噪音的直接波浪的三 decades.The 干扰现象在水下从海表面和海底部的目标和思考波浪能被看作浅水 waveguide.The 干扰有条纹或刻痕之状态的一个典型盒子直接波浪和它的思考的模式有效并且为更好理解浅水波导 invariant.The 的本质的全面数字干扰 pheno | LI Qihu WANG Lei WEI Chonghua LI Yi MA Xuejie YU Haichun | 2011 | Chinese Journal of Acoustics2011，30，1： | 13 |
| 3 | Effects of historical land cover changes on climate显示文摘In order to explore the influence of anthropogenic land use on the climate system during the last mil- lennium, a set of experiments is performed with an Earth system model of intermediate complexity—— the McGill Paleoclimate Model (MPM-2). The present paper mainly focuses on biogeophysical effects of historical land cover changes. A dynamic scenario of deforestation is described based on changes in cropland fraction (RF99). The model simulates a decrease in global mean annual temperature in the range of 0.09-0.16℃, especially 0.14-0.22℃ in Northern Hemisphere during the last 300 years. The responses of climate system to GHGs concentration changes are also calculated for comparisons. Now, afforestation is becoming an important choice for the enhancement of terrestrial carbon sequestration and adjustment of regional climate. The results indicate that biogeophysical effects of land cover changes cannot be neglected in the assessments of climate change. | SHI ZhengGuo YAN XiaoDong YIN ChongHua WANG ZhaoMin | 2007 | Chinese Science Bulletin2007，52，18： | 12 |
| 4 | Hydrophilic and strength-softening characteristics of calcareous shale in deep mines显示文摘To better understand the mechanism of the strength weakening process of soft rocks in deep mines after interacting with water, a self-developed experimental system, Intelligent Testing System for Water Absorption in Deep Soft Rocks (ITSWADSR), is employed to analyze the hydrophilic behavior of deep calcareous shale sampled from Daqiang coal mine. Experimental results demonstrate that the relation between water absorption and time can be expressed by power functions, and the soakage rate decreases while the soakage increases with time. In order to quantitatively calculate the weight coefficients of the influential factors for water absorbing capacity of rocks, a series of testing methods are adopted, including scanning electron microscope (SEM), X-ray diffraction and mercury injection test. It is demonstrated that the effective porosity has a positive correlation with the water absorbing capacity of rocks and the contents of illite and illite/smectite. The initial water content presents a negative correlation with the water absorption capacity of rocks. According to the absolute value of weight coefficients of various influential factors, the order of magnitude from high to low is captured: initial water content, illite, illite/smectite formation (S=5%), and the effective porosity. After water absorption tests, uniaxial compressive strength (UCS) tests were performed on rock specimens allowing a linear relationship between the UCS and the water content of rock to be established, indicating that the strength of calcareous shale decreases linearly with the increasing water content. | Hongyun Guo Manchao He Chonghua Sun Bing Li Feng Zhang | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，4： | 8 |
| 5 | Simulation of the climatic effects of natural forcings during the pre-industrial era显示文摘The MPM-2,an Earth system model of intermediate complexity,is employed to study the climate sys-tem response to natural forcings during the pre-industrial era (1000-1800 AD),with a special focus on the surface air temperature (SAT) evolution. Solar radiation and volcanism are the primary natural forcings during this period. In the MPM-2,the solar radiation forcing determines the long-term trend of the climate system change,and the volcanic forcing intensifies (weakens) this trend. Ultimately,the combination of solar and volcanic forcings dominates the long-term changes of the climate system. These results are in good agreement with other model data or temperature reconstructions. Natural forcings can well explain the Little Ice Age (LIA) and the Medieval Warm Period (MWP). At the large regional scale,the SAT response to natural forcings is almost coincident with that of the Northern Hemisphere. Based on MPM-2 model results,it is concluded that the global climate gradually became cold during the pre-industrial era. However,MPM-2 model results substantially correlate with recon-structed solar and volcanic forcings. Namely,to some great extent,these results strongly rely on the forcing series data we choose. Therefore,in order to accurately simulate the secular variation of the historical climate,it is very important to reconstruct well the solar radiation change and volcanic forc-ing data are well reconstructed for the past 10000 years,at least for the past 2000 years,in addition to the model improvements. The sensitivity study on the abrupt solar radiation change indicates that the increased solar radiation not only strengthens the nonlinear response of SAT,but intensifies the global hydrological cycle. At the same time,the biosphere is also affected obviously. | YIN ChongHua YAN XiaoDong SHI ZhengGuo WANG ZhaoMin | 2007 | Chinese Science Bulletin2007，52，11： | 7 |
| 6 | 中国东部沿海杨树人工林养分重吸收和化学计量对氮添加的响应显示文摘叶片养分重吸收对土壤养分的变化很敏感。然而,我们尚不清楚氮沉降如何影响植物大量元素重吸收率。杨树(Populus deltoids)是世界上栽培最广泛的阔叶树种之一。本文研究了在氮添加条件下,杨树重吸收率及其化学计量比的规律和主要驱动因素。通过一个4年的氮添加实验,我们探究中国东部沿海两个林分(8和12年)杨树人工林重吸收率及其化学计量比对氮添加的响应。我们测定了在一系列氮添加浓度水平(0、50、100、150、300 kg N ha^(−1) yr^(−1))下,土壤和叶片(包括绿叶和落叶)中氮、磷、钾、钙、镁的浓度。研究结果表明,除钙元素重吸收率和钙、镁元素重吸收率化学计量比外,氮添加对两个林分大量元素重吸收率及其化学计量比都没有显著影响。氮、磷重吸收率尺度斜率在不同氮添加水平下均小于1,表明氮添加条件下,氮、磷元素重吸收率解耦。养分重吸收率与绿叶中养分含量显著正相关,表明重吸收主要受到绿叶养分调控。我们的研究结果为中国东部沿海地区12年生杨树人工林的生长受氮限制提供了直接证据。 | Dalong Jiang Qian Li Qinghong Geng Menghua Zhang Chonghua Xu Guoqing Hu Caiqin Shen Honghua Ruan Xia Xu | 2021 | Journal of Plant Ecology2021，14，4： | 5 |
| 7 | A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis显示文摘 | Shicheng Su Qiang Liu Jingqi Chen Jianing Chen Fei Chen Chonghua He Di Huang Wei Wu Ling Lin Wei Huang Jin Zhang Xiuying Cui Fang Zheng Haiyan Li Herui Yao Fengxi Su Erwei Song | 2014 | Cancer Cell2014，，5： | 3 |
| 8 | Red carbon dots as label-free two-photon fluorescent nanoprobes for imaging of formaldehyde in living cells and zebrafishes显示文摘Direct,in situ selective detection of intracellular formaldehyde(FA)is of great significance for understanding its function in FA-related diseases.Herein,red carbon dots(RCD)are reported as label-free two-photon fluorescent nanoprobes for detecting and imaging of FA.Upon addition of FA,the-NH2 groups of RCD could quickly and specially react with aldehydes to form Schiff base and then the strong fluorescence of RCD with blue-shift emission is recovery due to the destruction of the hydrogen bond interaction between RCD and water.In addition,the nanoprobes exhibit outsta nding photo stability,rapid response(<1 min),high sensitivity(~9.9μmol/L)and excellent selectivity toward FA over other aldehyde group compounds.Notably,owing to the good cell-membrane permeability and biocompatibility,as well as the large two-photon absorption cross-section,the as-prepared RCD can be used as label-free nanoprobes for selectively detecting and imaging FA in living cells and zebrafishes through one-photon and two-photon excitation.Moreover,RCD could stain the tissue of zebrafishes at depths interval of up to 240μm under two-photon excitation.This research implied that RCD are promising tools for directly and in situ imaging FA in vivo,thus providing critical insights into FA-related pathophysiological processes. | Hong Wang Jing Wei Chonghua Zhang Yuan Zhang Yubin Zhang Lin Li Changmin Yu Peisheng Zhang Jian Chen | 2020 | Chinese Chemical Letters2020，31，3： | 3 |
| 9 | Sino-MONICA Project: A Collaborative Study on Trends and Determinants in Cardiovascular Diseases in China, Part I: Morbidity and Mortality Monitoring显示文摘 | Zhaosu Wu Chonghua Yao Dong Zhao Guixian Wu Wei Wang Jing Liu Zhechun Zeng Yingkai Wu | 2001 | Circulation: Journal of the American Heart Association2001，，1： | 3 |
| 10 | Overexpression of PITPNM3 promotes hepatocellular carcinoma cell metastasis显示文摘A previous study indicated that C–C chemokine(C–C motif)ligand 18(CCL18)is capable of inducing tumor cell invasion and metastasis by interacting with receptor membrane-associated phosphatidylinositol transfer protein 3(PITPNM3)in breast cancer cells.The present study aims to investigate the correlation between the PITPNM3 expression and metastasis in hepatocellular carcinoma(HCC).Real-time quantitative polymerase chain reaction and Western blot were performed to detect the expression pattern of PITPNM3 in patient samples and HCC cell lines.Wound-healing and transwell chamber assays were performed to assess the migration and invasiveness of HCC cells,and the activation of the signaling protein downstream of PITPNM3 was also detected by Western blot and immunofluorescence.The results revealed that PITPNM3 was upregulated in HCC tissue compared to matched normal liver tissue.Silencing the expression of PITPNM3 by specific siRNAs markedly attenuated the invasive and metastatic abilities of HCC cells,whereas the upregulation of PITPNM3 significantly increased HCC cell mobility.Furthermore,inhibiting the expression of PITPNM3 suppressed the activation of Pyk2,FAK,and Src,while overexpression of PITPNM3enhanced the phosphorylation of FAK and Src in HCC cells.Besides,suppression of Pyk2 can also impair the clustering of integrin.These results imply that PITPNM3 is a vital determinant of HCC migration and invasion. | Chonghua He Shicheng Su Fei Chen Di Huang Fang Zheng Wei Huang Jianing Chen Xiuying Cui Qiang Liu Erwei Song Herui Yao Yujie Liu | 2014 | Chinese Science Bulletin2014，59，12： | 3 |
| 11 | Multipath structure of the typical under-ice sound channel in the Arctic:theory and experiment显示文摘Considering the typical acoustic environment of the Arctic, this paper proposes a method based on OASES-Bellhop coupled model to rapidly analyze the multipath structure of the under-ice sound channel. Firstly the proposed model refers to ice plate as stratified elastic media with some roughness. Secondly,it uses the perturbation method and Kirchhoff approximation theory to solve the scattering loss due to the sea ice inhomogeneity. Finally, the model predicts the multipath structure of the under-ice channel through Ray theory. The results of the numerical simulation and experiment indicate that the typical Arctic sound channel presents multipath structures due to the sea ice and seabed in the range of 6 km, respectively.The sea ice reflection paths are stable,with a short multipath spread within 14 ms. The seabed reflection paths have relatively weak strength. The proposed OASES-Bellhop coupled model successfully predicts the amplitude and delay of the multipath structure with small error,which indicates the proposed model is able to analyze and predict the multipath structure of the observed acoustic environment in experiment. | LIU Chonglei HUANG Haining YIN Li LIU Na WEI Chonghua LI Qihu | 2019 | Chinese Journal of Acoustics2019，38，1： | 3 |
| 12 | Iterative inverse beamforming algorithm and its application in multiple targets detection of passive sonar显示文摘With the increasing of detection ability of passive sonar,the weak signal detection problem in multiple interferences becomes more and more important.In the time/bearing record(TBR) display of sonar detection,when there exist traces of multiple interferences,the identification of weak signal is difficult or impossible.The adaptive noise cancellation technique provides the theoretical basis for suppressing strong interferences.But the solution for finding the steady-state optimum filter matrix is quite difficult due to the real time calculation of inverse matrix of input data correlation matrix.The iterative inverse beamforming(IBF) algorithm for solving the optimum filter vector,which is expressed by inverse matrix of the ocean environment data,is derived in this paper,by which,the optimum filter can be eventually expressed as a sum of series simple matrices of constructed from sensor data.Based on the algorithm proposed in this paper,some examples of at sea experiment are provided.The strong interferences are cancelled and the weak signal is emerged,even it didn't appear in the conventional beamforming(CBF) processing. | LI Qihu WEI Chonghua XUE Shanhua | 2017 | Chinese Journal of Acoustics2017，36，2： | 2 |
| 13 | Repeated Use of MgNH4PO4·6H2O Residues for Ammonium Removal by Acid Dipping显示文摘 | Shujun Zhang Chonghua Yao Xiaoxi Feng | 2004 | Desalination2004，，170： | 1 |
| 14 | Repeated use of MgNH4PO4·6H2O residues for ammonium removal by acid dipping显示文摘 | Zhang Shujun Yao Chonghua Feng Xiaoxi | 2004 | Desalination2004，，17： | 1 |
| 15 | Some Thoughts on the Preservation of Historical and Cultural Cities | Wang Chonghua Zhang Pihe Shenyang Municipal Institute of Urban Planning and Design | 1990 | China City Planning Review1990，7，1： | 1 |
| 16 | Sino-MONICA project:A collaborative study on trends and determinants in cardiovascular disease in China,Part 1:Morbidity and mortality monitoring显示文摘 | Zhaosu Wu Chonghua Yao Dong Zhao | 2001 | Circulation2001，103，： | 1 |
| 17 | Repeated use of MgNH4PO4 ~ 6H2 0 residues for ammonium removal by acid dipping显示文摘 | Zhang Shujun Yao Chonghua Feng Xiaoxi ct al | 2004 | Desalination2004，170，： | 1 |
| 18 | Quality of life instruments for cancer patients显示文摘 | Wan Chonghua | 2000 | Quality Life Newsletters2000，25，： | 1 |
| 19 | Sino-MONICA Project: A Collaborative Study on Trends and Determinants in Cardiovascular Diseases in China, Part I: Morbidity and Mortality Monitoring显示文摘 | Zhaosu Wu Chonghua Yao Dong Zhao Guixian Wu Wei Wang Jing Liu Zhechun Zeng Yingkai Wu | 2001 | Circulation: Journal of the American Heart Association2001，，1： | 1 |
| 20 | Clinical Pharmacody namics of Meropenem in Patients with Lower Respiratory Tract Infections显示文摘 | Chonghua LI Xiaoli Du Joseph L | 2007 | Atim crobial agents and chemotherapy2007，51，5： | 1 |
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