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| 1 | A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction显示文摘Hyperhomocysteinemia(HHcy)is an independent risk factor for cardiovascular diseases and increases mortality in type 2 diabetic patients.HHcy induces endoplasmic reticulum(ER)stress and oxidative stress to impair endothelial function.The glucagon-like peptide 1(GLP-1)analog exendin-4 attenuates endothelial ER stress,but the detailed vasoprotective mechanism remains elusive.The present study investigated the beneficial effects of exendin-4 against HHcy-induced endothelial dysfunction.Exendin-4 pretreatment reversed homocysteine-induced impairment of endothelium-dependent relaxations in C57BL/6 mouse aortae ex vivo.Four weeks subcutaneous injection of exendin-4 restored the impaired endothelial function in both aortae and mesenteric arteries isolated from mice with diet-induced HHcy.Exendin-4 treatment lowered superoxide anion accumulation in the mouse aortae both ex vivo and in vivo.Exendin-4 decreased the expression of ER stress markers(e.g.,ATF4,spliced XBP1,and phosphorylated eIF2α)in human umbilical vein endothelial cells(HUVECs),and this change was reversed by cotreatment with compound C(CC)(AMPK inhibitor).Exendin-4 induced phosphorylation of AMPK and endothelial nitric oxide synthase in HUVECs and arteries.Exendin-4 increased the expression of endoplasmic reticulum oxidoreductase(ERO1α),an important ER chaperone in endothelial cells,and this effect was mediated by AMPK activation.Experiments using siRNA-mediated knockdown or adenoviral overexpression revealed that ERO1αmediated the inhibitory effects of exendin-4 on ER stress and superoxide anion production,thus ameliorating HHcy-induced endothelial dysfunction.The present results demonstrate that exendin-4 reduces HHcy-induced ER stress and improves endothelial function through AMPK-dependent ERO1αupregulation in endothelial cells and arteries.AMPK activation promotes the protein folding machinery in endothelial cells to suppress ER stress. | Chak Kwong Cheng Jiang-Yun Luo Chi Wai Lau William Chi-shing Cho Chi Fai Ng Ronald Ching Wan Ma Xiao Yu Tian Yu Huang | 2021 | Acta Pharmacologica Sinica2021，42，10： | 6 |
| 2 | DICER-LIKE3 Activity in Physcomitrella patens DICER-LIKE4 Mutants Causes Severe Developmental Dysfunction and Sterility显示文摘交易的小介入 RNA (ta-siRNAs ) 是在 microRNA 依赖的劈开,进双 stranded RNA 的变换,和骰子依赖者分阶段执行处理以后,免除 TAS 先锋抄本的植物特定的 siRNAs。象 microRNAs (miRNAs ) 一样, ta-siRNAs 在广泛的补充的地点的目标 RNA 的直接地点特定的劈开。这里,我们证明像骰子 Physcomitrella 圣餐盘(PpDCL4 ) 的 4 蛋白质为 21 核苷酸(nt ) 的生物的续生说是必要的 ta-siRNAs。在 PpDCL4 异种,离开缩放 23 并且 24-nt ta-siRNAs 作为 PpDCL3 的结果积累了活动。PpDCL4 异种在整个 Physcomitrella 开发显示严重畸形,包括绝育,那充分在 PpDCL3/PpDCL4 双异种植物被颠倒。因此, PpDCL3 活动,不是 PpDCL4 功能本身的损失,是 PpDCL4 显型的原因。另外,我们描述几新 Physcomitrella 交易 siRNA loci,其三属于一个新家庭, TAS6。TAS6 loci 被切的 miR156 和 miR529 目标地点代表并且在到 PpTAS3 loci 的靠近的最近。 | M. Asif Arif Isam Fattash Zhaorong Ma Sung Hyun Cho Anna K. Beike Ralf Reski Michael J. Axtell Wolfgang Frank | 2012 | Molecular Plant2012，5，6： | 4 |
| 3 | The role of adhesion molecules in gastri c ulcer healing显示文摘Gastriculcerisadeepnecroticlesioninvolvingtheentiremucosaldepthandthemuscularismucosae.Ulcerhealingisanactiveandcomplicatedpr... | CHOW JYC, MA L and CHO CH | 1998 | World Journal of Gastroenterology1998，4，6： | 3 |
| 4 | Acoustic emission source analysis of plasma sprayed thermal barrier coatings during four-point bend tests 显示文摘 | Ma X Q Cho S Takemoto M | 2001 | Surface and Coatings Technology2001，139，： | 1 |
| 5 | Oncogenic CagA promotes gastric cancer risk via activating ERK signaling pathways :a nested case-control study显示文摘 | Yang JJ Cho LY Ma SH | 2011 | PLoS One2011，6，21： | 1 |
| 6 | Human mannose-binding lectin and L-ficolin function as specific pattern recognition proteins in the lectin activation pathway of com- plement显示文摘 | Ma YG Cho MY Zhao M Park JW Matsushita M Fujita T | 2004 | J Biol Chem2004，279，25： | 1 |
| 7 | Molecular genetiC diversity and population structure in Lycium accessions using SSR markers显示文摘 | Zhao W G Chung J W Cho Y I Rha W H Lee G A Ma K H Han S H Bang K H Park C B Kim S M Park Y J | 2010 | C R Bioi2010，333，： | 1 |
| 8 | Mitogen-activated protein kinases mediate matrix metalloproteinase-9 expression in vascular smooth muscel cells 显示文摘 | Cho A Graves J Reidy MA | 2000 | Arterioscler Thromb Vasc Biol2000，20，12： | 1 |
| 9 | A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity显示文摘 | Kim D Kim MA Cho IH | 2007 | J Biol Chem2007，282，14： | 1 |
| 10 | Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease显示文摘 | Jung Mi Choi Myoung Soo Woo Hyeo-Il Ma Suk Yun Kang Young-Hee Sung Seok Woo Yong Sun Ju Chung Joong-Seok Kim Hae-won Shin Chul Hyoung Lyoo Phil Hyu Lee Jong Sam Baik Sang-Jin Kim Mee Young Park Young Ho Sohn Jin-Ho Kim Jae Woo Kim Myung Sik Lee Myoung Cho | 2008 | Neurogenetics2008，，4： | 1 |
| 11 | Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury 显示文摘 | Cho A Reidy MA | 2002 | Circ Res2002，91，9： | 1 |
| 12 | p53 controls autoimmune arthritis via STAT-mediated regulation of the Thl7 celL/Treg cell balance in mice显示文摘 | Park JS Lim MA Cho ML | 2013 | Arthritis Rheum2013，65，4： | 1 |
| 13 | Impact of exercise onheart rate recovery显示文摘 | Jolly MA Brennan DM Cho L | 2011 | Circulation2011，124，14： | 1 |
| 14 | A metal-organic framework material that functions as an enantioselective catalyst for olefin epoxidation显示文摘 | Cho S H Ma B Nguyen S T | 2006 | Chem Comm2006，，： | 1 |
| 15 | Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury显示文摘 | Cho A Reidy MA | 2002 | Circ Res2002，91，9： | 1 |
| 16 | Mitogen-activated protein kinases mediate matrix metalloproteinase-9 expression in vascular smooth muscle cells显示文摘 | Cho A Graves J Reidy MA | 2000 | Arterioscler Thromb Vasc Biol2000，20，： | 1 |
| 17 | A study of indium tin oxide thin film deposited at low temperature using facing target sputtering system 显示文摘 | Ma H B Cho J S Park C H | 2002 | Surface and Coating Technology2002，153，23： | 1 |
| 18 | Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury显示文摘 | Cho A Reidy MA | 2002 | Circ Res2002，91，9： | 1 |
| 19 | A Study of Indium Tin Oxide Thin Film Deposited at Low Temperature Using Facing Target Sputtering System显示文摘 | Ma H B Cho J S Park C H | 2002 | Surface and Coating Technology2002，153，23： | 1 |
| 20 | An experimental model for studying passive cigarette smoking effects on gastric ulceration显示文摘 | J.Y.C. Chow L. Ma C.H. Cho | 1996 | Life Sciences1996，，26： | 1 |
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