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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Effect of dietary fish oil supplementation on cellular adhesion molecule expression and tissue myeloperoxidase activity in diabetic mice with sepsis 显示文摘 | Chiu WC Hou YC Yeh CL | 2007 | Br J Nutr2007，97，4： | 1 |
| 3 | A comparison of dexmedetomidine and midazolam for sedation in third molar surgery显示文摘 | CHEUNG CW YING CL CHIU WK et d | 2007 | Anaesthesia2007，62，11： | 1 |
| 4 | Menopausal hormone therapy:examining cardiovascular and clinical impacts of treatment显示文摘 | Chiu CL Lind JM | 2013 | Future Cardiol2013，9，： | 1 |
| 5 | Menopausal hormone therapy is associated with having high blood pressure in postmenopausal women:observational cohort study显示文摘 | Chiu CL Lujic S Thornton C | 2012 | PLo S One2012，7，40： | 1 |
| 6 | Effects of omega-3 fatty acids on inflammatory mediators and splenocyte cytokine mRNA expression in rats with polymicrobial sepsis显示文摘 | Tsou SS Chiu WC Yeh CL | 2008 | Nutrition2008，24，5： | 1 |
| 7 | Sensitivity and specificity of the Clock Drawing Test,incorporating Rouleau scoring system,as a screening instrument for questionable and mild dementia:scale development显示文摘 | Chiu YC Li CL Lin KN | 2008 | Int J Nurs Stud2008，45，： | 1 |
| 8 | Endoscopic submucosal dissection vs laparoscopic colorectal resection for early colorectal epithelial neoplasia显示文摘AIM: To compare the short term outcome of endoscopic submucosal dissection(ESD) with that of laparoscopic colorectal resection(LC) for the treatment of early colorectal epithelial neoplasms that are not amenable to conventional endoscopic removal. METHODS: This was a retrospective cohort study. The clinical data of all consecutive patients who underwent ESD for endoscopically assessed benign lesions that were larger than 2 cm in diameter from 2009 to 2013 were collected. These patients were compared with a cohort of controls who underwent LC from 2005 to 2013. Lesions that were proven to be malignant by initial endoscopic biopsies were excluded. Mid and lower rectal lesions were not included because total mesorectal excision, which bears a more complicated postoperative course, is not indicated for lesions without histological proof of malignancy. Both ESD and LC were performed by the same surgical unit with a standardized technique. The patients were managed according to a standard protocol, and they were closely monitored for complications after the procedures. All hospital records were reviewed, and the following data were compared between the ESD and LC groups: patient demographics, size and location of the lesions, procedure time, shortterm clinical outcomes and pathology results. RESULTS: From 2005 to 2013, 65 patients who underwent ESD and 55 patients who underwent LC were included in this study. The two groups were similar in terms of sex(P = 0.41) and American Society of Anesthesiologist class(P = 0.58), although patients in the ESD group were slightly older(68.6 ± 9.4 vs 64.6 ± 9.9, P = 0.03). ESD could be accomplished with a shorter procedure time(113 ± 66 min vs 153 ± 43 min, P < 0.01) for lesions of comparable size(3.0 ± 1.2 cm vs 3.4 ± 1.4 cm, P = 0.22) and location(colon/rectum:59/6 vs colon/rectum: 52/3, P = 0.43). ESD appeared to be associated with a lower short-term complication rate, but the difference did not reach statistical significance(10.8% vs 23.6%, P = 0.06). In the LC arm, a total of 22 complications occurred in 13 patients. A total of 7 complications occurred in the ESD arm, including 5 perforations and 2 episodes of bleeding. All perforations were observed during the procedure and were successfully managed by endoscopic clipping without emergency surgical intervention. Patients in the ESD arm had a faster recovery than patients in the LC arm, which included shorter time to resume normal diet(2 d vs 4 d, P = 0.01) and a shorter hospital stay(3 d vs 6 d, P < 0.01). CONCLUSION: ESD showed better short-term clinical outcomes in this study. Further prospective randomized studies will be required to evaluate the efficacy and superiority of colorectal ESD over LC. | Sophie SF Hon Simon SM Ng Tiffany CL Wong Philip WY Chiu Tony WC Mak WW Leung Janet FY Lee | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，17： | 1 |
| 9 | Temporary cardiopulmonary bypass and isolated lung ventilation for tracheal stenosis and reconstruction 显示文摘 | Chiu CL The BT Wang CY | 2003 | Br J Anaeasth2003，91，： | 1 |
| 10 | A novel predictor of cancer malignancy:up-regulation of myristoylated alanine-rich C kinase Substrate phosphorylation in lung cancer显示文摘 | Chen CH Chiu CL Adler KB | 2014 | Am J Respir Crit Care Med2014，189，8： | 1 |
| 11 | Effect of rocuronium compared with succinylcholine on intraocular pressure during rapid sequence induction of anaesthesia 显示文摘 | Chiu CL Jaais F Wang CY | 1999 | Br J Anaesth1999，82，： | 1 |
| 12 | Endoscopic harvest of saphenous vein: a lesson learned from t 348 cases显示文摘 | Chiu KM Chen CL Chu SH | 2008 | Surg Endosc2008，22，1： | 1 |
| 13 | Ethanol effects on nitricoxide production in cerebral pial cultures 显示文摘 | Shih CL Chi SI Chiu TH | 2001 | AlcoholClin Exp Res2001，25，4： | 1 |
| 14 | Protective effect of melatonin on liverischemia-reperfusion induced pulmonary microvascular injury in rats显示文摘 | Chiu MH Su CL Chen CF | 2012 | Transplant Proc2012，44，4： | 1 |
| 15 | Sustained low -efficiency daily diafiltration with hemoperfusion as a therapy for severe star fruit intoxication: a report of two cases显示文摘 | Wu CL Chiu PF Yang Y | 2011 | Ren Fail2011，33，8： | 1 |
| 16 | Identification of allergeniccomponent Tyr p 8 from Tyrophagus putrescentiae and cross- reactivity with Der p 8 显示文摘 | Liao EC Lin YH Chiu CL | 2013 | Clin Vaccine Immunol2013，20，4： | 1 |
| 17 | Glutamine modulates lipopolysaccharide-induced activation of NF-κB via the Akt/mTOR pathway in lung epithelial cells显示文摘 | Hou YC Chiu WC Yeh CL | | 0，，： | 1 |
| 18 | Effect of roeuronium compared with succinylcholine on intraocular pressure during rapid sequence induction of anaesthesia显示文摘 | Chiu CL Jaais F Wang CY | 1999 | Br J Anaesth1999，82，5： | 1 |
| 19 | Temporary cardiopulmonary bypass and isolated lung ventilation for tracheal stenosis and reconstruction显示文摘 | Chiu CL Teh BT Wang CY | 2003 | Br J Anaesth2003，91，5： | 1 |
| 20 | Factors influencing the resonance frequency of dental implants显示文摘 | Huang HM Chiu CL Yeh CY | 2003 | J Oral Maxillofac Surg2003，61，10： | 1 |
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