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| 1 | Viral manipulation of cellular protein conjugation pathways: The SUMO lesson显示文摘Small ubiquitin-like modifier(SUMO)ylation is a key posttranslational modification mechanism that controls the function of a plethora of proteins and biological processes. Given its central regulatory role, it is not surprising that it is widely exploited by viruses. A number of viral proteins are known to modify and/or be modified by the SUMOylation system to exert their function, to create a cellular environment more favorable for virus survival and propagation, and to prevent host antiviral responses. Since the SUMO pathway is a multi-step cascade, viral proteins engage with it at many levels, to advance and favor each stage of a typical infection cycle: replication, viral assembly and immune evasion. Here we review the current knowledge on the interplay between the host SUMO system and viral lifecycle. | Domenico Mattoscio Chiara V Segré Susanna Chiocca | 2013 | World Journal of Virology2013，2，2： | 8 |
| 2 | Phase ib trial of oncolytic herpes virus G207 shows safety of multiple injections and documents viral replication显示文摘 | Aghi M K Chiocca E A | 2009 | Mol Ther2009，17，1： | 1 |
| 3 | A retrospective analysis of reasons for reoperation following initially successful peripheral nerve stimulation显示文摘 | Ishizuka K Oaklander A L Chiocca E A | 2007 | J Neurosurg2007，106，3： | 1 |
| 4 | Enhancement of Gene Therapy Specificity for Diffuse Colon Carcinoma Liver Metastases with Recombinant Herpes Simplex Virus显示文摘 | Nancy M. Carroll E. Antonio Chiocca Kazuhisa Takahashi Kenneth K. Tanabe | 1996 | Annals of Surgery1996，，3： | 1 |
| 5 | Viruses and sumoylation:recent highlights显示文摘 | Boggio R Chiocca S | 2006 | Curr Opin Microbiol2006，9，4： | 1 |
| 6 | The Gss-inked receptor GPR3 inhibits the proliferation of cerebellar granule cells during postnatal development显示文摘 | Tanaka S Shaikh IM Chiocca EA | | 0，，06： | 1 |
| 7 | 脂肪-蓝湿革上真菌生长的营养物质显示文摘蓝湿革上真菌的生长会带来许多技术问题,甚至会严重影响制革者的经济效益。目前,控制真菌的生长通常能够成功地预防蓝湿革长霉,但针对这个问题更为有效解决方案的开发,仍是近年关注的热点。关于皮革上真菌生长问题,大多数研究都侧重几种杀菌剂对真菌的的预防效果。然而,为了提供更多有效的方法来解决皮革霉菌问题,微生物学、生物化学和组织学等科学领域都应进行深入研究。Zugno等人(2009)的一项研究就是考察几种真菌菌株在蓝湿革上(未用杀菌剂处理)的生长。结果表明,这些天然的油和脂肪都是真菌的主要营养源,并且没有证据表明经鞣制的结构性蛋白成分遭到破坏。因此,基本可以推断出,造成皮革损伤的物理-化学变化,主要是由于脂肪的降解和去除,以及随后在复鞣、染色和加脂工序中吸收了不同的化学材料而引起。本文主要研究了几种常用的加脂剂和天然油脂对蓝湿革上真菌生长的影响。这将有助于采用更加低毒环保的手段来有效地控制真菌生长。 | Rossana Chiocca Elton Hurlow Francieli Batista Marcelo F.Sousa George B.Stockman 孔纤(译) 余跃(校) | 2017 | 中国皮革2017，46，10： | 1 |
| 8 | a Primer for Neurosurgeons显示文摘 | Chiocca E A Gene Therapy | 2003 | Neurosurgery2003，53，2： | 1 |
| 9 | PI3K/mTOR mediate mitogen-dependent HDAC1 phosphorylation in breast cancer:a novel regulation of estrogen receptor expression显示文摘Histone deacetylase 1(HDAC1)is an important epigenetic controller involvedin transcriptional regulation throughmodification of chromatin structure.Genetic and epigenetic changes and deregulation of signal transduction pathways have been implicated in the development of breast cancer.Downregulation of estrogen receptor a(ERa)expression is one of the mechanisms behind the acquisition of endocrine resistance.Sustained and increased hormone and growth factor receptor signaling in breast cancer cells contribute to resistance to endocrine therapy.Both HDACs and the PI3K/mTOR signaling pathway are becoming promising targets in breast cancer,reversing also acquired hormone resistance.Here we show how mitogens,activating the PI3K/mTOR pathway,trigger the phosphorylation of HDAC1 in breast cancer cells,which is completely dependent on the activity of the p70 S6 kinase(S6K1).Our findings show that S6K1,overexpressed in many breast cancers,controls HDAC1-dependent transcriptional regulation of ERa levels upon mitogenic stimuli,controlling HDAC1 recruitment to the ERa promoter.Furthermore,cell treatment with both mTOR and HDACs inhibitors shows an additive effect in inhibiting breast cancer proliferation.This confirms the novel cross-talk between the HDAC1 and PI3K pathways with clinical implications towards the treatment of this malignant disease. | Simona Citro Claudia Miccolo Laura Meloni Susanna Chiocca | 2015 | Journal of Molecular Cell Biology2015，7，2： | 1 |
| 10 | Prevalence,clinical spectrum and atypical symptoms of gastro-oesophageal reflux in Argentina:a nationwide population-based study显示文摘 | Chiocca JC Olmos JA Salis GB | 2005 | Aliment Pharmacol Ther2005，22，： | 1 |
| 11 | Prevalence,clinical spectrum and atypical symptoms of gastro-oesophageal reflux in Argentina:a nationwide population-based study显示文摘 | Chiocca JC Olmos JA Salis GB | 2005 | Aliment Pharmacol Ther2005，22，4： | 1 |
| 12 | Co-expression of Fas and Fas ligand in malignant glial tumors and cell lines显示文摘 | Husain N Chiocca EA | 1998 | Acta Neuropathol Berl1998，95，3： | 1 |
| 13 | Measuring transferrin receptor gene expression by NMR imaging显示文摘 | Anna Moore James P Basilion E.Antonio Chiocca Ralph Weissleder | 1998 | BBA - Molecular Cell Research1998，，3： | 1 |
| 14 | Petroclival meningioma presenting with pathological laughter显示文摘 | Shafqat S Elkind M Chiocca EA | 1998 | Neurology1998，50，7： | 1 |
| 15 | Emerging functions of microRNAs in glioblastoma 显示文摘 | Lawler S Chiocca EA | 2009 | J Neurooncol2009，92，3： | 1 |
| 16 | Measuring transferrin receptor gene expression by NMR imaging显示文摘 | Moore A Basilion JP Chiocca EA | 1998 | Biochim Biophys Acta1998，1402，3： | 1 |
| 17 | Gam1and the SUMO pathway显示文摘 | Boggio R Chiocca S | 2005 | CellCycle2005，4，4： | 1 |
| 18 | Targeting SUMO E1toubiquitin ligases:a viral strategy to counteract sumoylation显示文摘 | Boggio R Passafaro A Chiocca S | 2007 | J Biol Chem2007，282，15： | 1 |
| 19 | Cancer gene therapy using a replication Ⅰ competent herpes simplex virus type Ⅰ vector显示文摘 | Yoon SS Carroll NM Chiocca EA | | 0，，： | 1 |
| 20 | Treatment of glioma by engineered interleukin 4-secreting cells 显示文摘 | Yu JS Wei MX Chiocca EA | 1993 | Cancer Res1993，53，13： | 1 |
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