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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | Treatment of Helicobacter pylori in surgical practice:A randomised trial of triple versus quadruple therapy in a rural district general hospital显示文摘AIM: To compare a lansoprazole-based triple versus quadruple therapy for Helicobacter pylori (H pylori) eradication with emphasis on side effect prof ile,patient compliance and eradication rate at a rural district general hospital in Wales,United Kingdom. METHODS: One hundred one patients with H pylori infection were included in the study. Patients were randomised to receive triple therapy comprising of lansoprazole 30 mg,amoxycillin 1 g,clarithromycin 500 mg,all b.d. (LAC),or quadruple therapy comprising of lansoprazole 30 mg b.d.,metronidazole 500 mg t.d.s.,bismuth subcitrate 240 mg b.d.,and tetracycline chloride 500 mg q.d.s. (LMBT). Cure was defi ned as a negative 13C urea breath test 2 mo after treatment. RESULTS: Seven patients were withdrawn after randomisation. Fifty patients were assigned to LAC group and 44 to LMBT group. The intention-to-treat cure rates were 92% and 91%,whereas the per-protocol cure rates were 92% and 97%,respectively. Side effects were common,with 56% experiencingmoderate to severe symptoms in the LAC group and 59% in the LMBT group. Symptoms of vomiting,diarrhoea and black stools were significantly more common in the LMBT group. Patient compliance was 100% for triple therapy and 86% for quadruple therapy (P < 0.01). One-third of patients in both groups were still taking acid-reducing medications at six-month follow-up. CONCLUSION: One-week triple and quadruple therapies have similar intention-to-treat eradication rates. Certain side effects are more common with quadruple therapy,which can compromise patient compliance. Patient education or modifi cations to the regimen are alternative options to improve compliance of the quadruple regimen. | Siok Siong Ching Sivakumaran Sabanathan Lloyd R Jenkinson | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 4 | Factorized banded inverse preconditioners for matrices with Toeplitz structure 显示文摘 | Lin F R Ng M K Ching W K | 2005 | Siam Journal on Scientific Computing2005，26，6： | 1 |
| 5 | Suggesting a di-omega dibaryon search in heavy ion collision experiments显示文摘 | ZHANG Z Y YU Y W CHING C R | 2000 | Phys Rev2000，61，06： | 1 |
| 6 | Angiogene- sis inhibition in prostate cancer: current uses and future promises 显示文摘 | ARAGON CHING J B MADAN R A DAHUT W L | 2010 | JOncol2010，2010，36： | 1 |
| 7 | Sequence selective binding of peptides by artificial receptors in aqueous solution显示文摘 | Breslow R Yang Z Ching R | 1998 | J Am Chem Soc1998，120，14： | 1 |
| 8 | The effects of nanoparticle aggregation processes on aggregate structure and metal uptake 显示文摘 | Gilbert B Ono R K Ching K A | 2009 | Journal of Colloid and Interface Science2009，339，2： | 1 |
| 9 | Effect of temperature on seed dormancy of wheat 显示文摘 | Reddy L V Metzger R J Ching T M | 1985 | Crop Sci1985，25，3： | 1 |
| 10 | A systematic arrangement of the Chinese fern families and genera with corresponding names in Chinese显示文摘 | CHING R C | 1954 | Acta Phytotax Sinica1954，3，1： | 1 |
| 11 | Production of bioactive human beta-defensin 5 and 6 in Escherichia coli by soluble fu- sion expression显示文摘 | Huang L Ching CB Jiang R | 2008 | Protein E:cpr Purif2008，61，2： | 1 |
| 12 | Effect of number of mesh layers and fluid loading on the performance of screen mesh wicked heat pipes 显示文摘 | Kempers R Ewing D Ching C Y | 2006 | Applied Thermal Engineering2006，26，： | 1 |
| 13 | Determining the factors of safety of spatially variable slopes modeled by random fields显示文摘 | TABARROKI M AHMAD F BANAKI R JHA S CHING J | 2013 | Journal of Geotechnical and Geoenvironmental Engineering2013，139，12： | 1 |
| 14 | Determination of the energy equivalent of a water solution calorimeter with a standard substance 显示文摘 | Mnotgomery R L Melaugh R A Ching L | 1977 | J Chem Thermodynamics1977，，9： | 1 |
| 15 | Co-production and its effects on service innovation 显示文摘 | Chen J S Tsou H T Ching R K H | 2011 | Industrial Marketing Management2011，40，8： | 1 |
| 16 | The studies of Chinese ferns Ⅶ:A revision of the genus Tectaria from China and Sikkime-Himalaya显示文摘 | CHING R C | 1931 | Sinensia1931，2，2： | 1 |
| 17 | Genes associated with the end of dormancy in grapes 显示文摘 | PACEY-MILLER T SCOTY K ABLETY E TINGEY S CHING A HENRY R | 2003 | Fuctional Integrative Genomics2003，3，4： | 1 |
| 18 | Subluxation of the talocalcaneal joint in adults who have symptomatic flatfoot 显示文摘 | Ananthakrisnan D Ching R Tencer A | 1999 | J Bone Joint Surg Am1999，81，8： | 1 |
| 19 | Parotid metastasis-an independent prognostic factor for head and neck cutaneous squamous cell carcinoma 显示文摘 | Ching S Maitra A Lea R | 2006 | J Plast Reconstr Aesthel Surg2006，59，12： | 1 |
| 20 | Production of bioactive human beta defensin 5 and 6 in Escherichia coli by soluble fusion expression 显示文摘 | Huang L Ching C B Jiang R | 2008 | Protein Expression and Purifica- tion2008，61，2： | 1 |
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