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| 1 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 2 | Interesting physical properties of the new spinel phase of Si《,3》N《,4》 and C《,3》N《,4》显示文摘 | Ouyang L Z and Ching W Y | 1999 | Physical Review Letters1999，83，： | 1 |
| 3 | Determinants of the decision to submit market or limit orders on the ASX 显示文摘 | Verhoeven P Ching S Guan H | 2004 | Pacific-Basin Finance Journal2004，12，1： | 1 |
| 4 | Demonstration of receptor binding properties of VP2 of very virulent strain infectious bursal disease virus on Veto cells显示文摘 | Chi W Y Yin S Y Ching M M | 2007 | Virus Res2007，123，1： | 1 |
| 5 | Higher-order multivariate Markov chains and their applications显示文摘 | Ching W K Ng M K Fung E S | 2008 | Linear Algebra and its Applications2008，428，2： | 1 |
| 6 | Theoretical prediction of the structure and properties of cubic spinel nitrides显示文摘 | Mo S D Ouyang L Z | 2002 | Journal of the American Ceramic Society2002，85，： | 1 |
| 7 | Interesting physical properties of the new spinel phase of Si3 N4 and C3N4显示文摘 | MO S D OUYANG L CHING W Y | 1999 | Phys Rev Lett1999，83，24： | 1 |
| 8 | Higher-order multivariate Markov chains and their applications显示文摘 | Ching W K Ng M K Fung E S | 2008 | Linear Algebra and its Applica- tions2008，428，2： | 1 |
| 9 | Technology for automated, rapid,and quantitative PCR or reverse transcription-PCR clinical testing显示文摘 | Raja S Ching J Xi L | 2005 | Clin Chem2005，51，5： | 1 |
| 10 | Drained Permanent Deformation of Sand Due to Cyclic loading显示文摘 | Ching S chang Robert V Whitman | 1988 | Journal of the Geotechnical Engineering1988，114，10： | 1 |
| 11 | Oxidative degradation of 2, 4, 6-Trinitrotoluene by ozone in an electrohydraulic discharge reactor显示文摘 | Lang P S Ching W K Willberg D M | 1998 | Environ Sci Technol1998，32，20： | 1 |
| 12 | Hybrid subset simulationmethod for reliability estimation of dynamical systemssubject to stochastic excitation显示文摘 | Ching J Beck J L Au S K | 2005 | ProbabilisticEngineering Mechanics2005，20，19： | 1 |
| 13 | Intrinsic mechanical properties of 20 MAX-phase compounds 显示文摘 | Ching W Y Mo Y Aryal S | 2013 | J Am Ceram Soc2013，96，7： | 1 |
| 14 | IFN-beta-dependent inhibition of tumor growth by the vascular disrupting agent 5, 6-dimethylxanthe- none-d-acetic acid (DMXAA) 显示文摘 | Roberts Z J Ching L M Vogel S N | 2008 | J Interferon Cytokine Res2008，28，3： | 1 |
| 15 | Global Linkages,the Chinese High-tech Community and Industrial ClusterDevelopment : the Semiconductor Industry in Wuxi Jiang-su显示文摘 | Chou T L Ching C H Fan S | 2011 | Urban Studies2011，48，14： | 1 |
| 16 | Application of subsetsimulation methods to reliability benchmark problems显示文摘 | Au S K Ching J Beck J L | 2007 | Structural Safety2007，29，18： | 1 |
| 17 | DiffuNet:theimpact of network structure on diffusion of innovation显示文摘 | BEN S CHING L RAVINRANATH M | 2005 | European Journal of Innovation Management2005，8，2： | 1 |
| 18 | The detection of dioxin- and estrogen-like pollutants in marine and freshwater fishes cultivated in Pearl River Delta, China显示文摘 | Wei X Ching L Y Cheng S H | 2010 | Environmental Pollution2010，158，6： | 1 |
| 19 | Electronic Structure of Normal, Inverse,and Partially Inverse Spinels in the MgAl2O4 System 显示文摘 | Mo S D Ching W Y | 1996 | Phys Rev B1996，54，16： | 1 |
| 20 | On wavelet denoising and its application to time delay estimation 显示文摘 | Ching P C So H C Wu S Q | 1999 | IEEE Trans on SP1999，47，10： | 1 |
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