|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 3 | Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification显示文摘AIM To examine effects of computed tomography(CT)image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes.METHODS This study was performed in conformance with HIPAA and IRB Regulations(March 2015-November 2016).A ten blood clot phantom was designed and scanned on a dual-energy CT scanner(SOMATOM Force,Siemens Healthcare Gm BH,Erlangen,Germany)with varying pitch,iterative reconstruction,energy level and slicethickness.A range of clot and tube sizes were used in an attempt to replicate in vivo emboli found within central and segmental branches of the pulmonary arteries in patients with pulmonary emboli.Clot volume was the measured parameter and was analyzed by a single image analyst using a semi-automated region growing algorithm implemented in the FDA-approved Siemens syngo.via image analysis platform.Mixed model analysis was performed on the data.RESULTS On the acquisition side,the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification(P=0.9898).On the other hand,when considering the fixed factor of pitch,there were statistically significant differences in clot volume quantification(P<0.0001).On the reconstruction side,with the continuous factor of reconstruction slice thickness no statistically significant effect on absolute clot volume quantification was demonstrated(P=0.4500).Also on the reconstruction side,with the fixed factor of using iterative reconstructions there was also no statistically significant effect on absolute clot volume quantification(P=0.3011).In addition,there was excellent R^2 correlation between the scale-measured mass of the clots both with respect to the CT measured volumes and with respect to volumes measure by the water displacement method.CONCLUSION Aside from varying pitch,changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，3： | 3 |
| 4 | miR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signaling 显示文摘 | WONG Q W CHING A K CHAN A W | 2010 | Clin Cancer Res2010，16，3： | 1 |
| 5 | Biomechanical evaluation of metacarpal fracture f'Lxation: application of a 90° internal fixation model显示文摘 | Watt A J Ching RP Huang J1 | 2015 | Hand ( N Y)2015，10，1： | 1 |
| 6 | Rooting of Alnus rubra cuttings 显示文摘 | Monaco P A T M Ching K K Ching | 1980 | Tree Planters'' Notes1980，31，3： | 1 |
| 7 | Detection of machine failure:hidden Markov model approach显示文摘 | TAI A H CHING W K CHAN L Y | 2009 | Computers and Industrial Engineering2009，57，2： | 1 |
| 8 | Angiogene- sis inhibition in prostate cancer: current uses and future promises 显示文摘 | ARAGON CHING J B MADAN R A DAHUT W L | 2010 | JOncol2010，2010，36： | 1 |
| 9 | Comparative studies on alkylation of phenol with tertbutyl alcohol in the presence of liquid or solid catalysts in ionil liquids显示文摘 | SHEN Hao - yu Zaher M A CHI Bun - ching XIA Qing - hua | 2004 | Journal of molecular catalysis A: chemcal2004，212，： | 1 |
| 10 | Identification and characterization of the hypoxia-responsive element in human stanniocalcin-l gene 显示文摘 | Law A YS Ching L Y Lai KP | 2010 | Mol Cell Endocrinol2010，314，1： | 1 |
| 11 | Interspinous spacers compared with decompression or fusion for lumbar stenosis:complications and repeat operations in the Medicare population显示文摘 | Deyo RA Martin BI Ching A | 2013 | Spine2013，38，10： | 1 |
| 12 | Large-scale analysis of the human and mouse rranscriptomes显示文摘 | SU A I COOKE M P CHING K A | 2002 | Proc Natl Acad Sci USA2002，99，7： | 1 |
| 13 | Sp1is a transcription repressor to stanniocalcin-1expression in TSA-treated human colon cancer cells,HT29显示文摘 | Law A Y Yeung B H Ching L Y | 2011 | J Cell Biochem2011，112，8： | 1 |
| 14 | Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3显示文摘 | Ching T T Maunakea A K Jun P | 2005 | Nat Genet2005，37，6： | 1 |
| 15 | Class-dependent discretization for inductive learning from continuous and mixed mode data显示文摘 | CHING J Y WONG A K C CHAN K C C | 1995 | IEEE Transactions on Pattern Analysis and Machine Intelligence1995，17，7： | 1 |
| 16 | The effects of nanoparticle aggregation processes on aggregate structure and metal uptake 显示文摘 | Gilbert B Ono R K Ching K A | 2009 | Journal of Colloid and Interface Science2009，339，2： | 1 |
| 17 | Cimetidine and other H2 receptor antagonists as powerful hydroxyl radical scavengers显示文摘 | Ching TL Haenen GR Bast A | 1993 | Chem Biol Interact1993，86，2： | 1 |
| 18 | Influence of annealing on the microstructural, tensile and fracture properties of Polypropylene films显示文摘 | FERRER-BALAS D MASPOCH M L MARTINEZ A B CHING E MAI Y W | 2001 | Polymer2001，42，： | 1 |
| 19 | MiR-145 modulates multiple components of the insulin-like growth factor pathway in hepatocellular carcinoma显示文摘 | Law P T Ching A K Chan A W | | 0，，6： | 1 |
| 20 | Rotation,scale and translation resilient watermarking for images显示文摘 | LIN CHING YUNG WU MIN BLOOM J A | 2001 | In IEEE Trans On Image Processing2001，10，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员