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| 1 | Apparent diffusion coefficient by diffusion-weighted magnetic resonance imaging as a sole biomarker for staging and prognosis of gastric cancer显示文摘Objective:To investigate the role of apparent diffusion coefficient(ADC)from diffusion-weighted magnetic resonance imaging(DW-MRI)when applied to the 7th TNM classification in the staging and prognosis of gastric cancer(GC).Methods:Between October 2009 and May 2014,a total of 89 patients with non-metastatic,biopsy proven GC underwent 1.5T DW-MRI,and then treated with radical surgery.Tumor ADC was measured retrospectively and compared with final histology following the 7th TNM staging(local invasion,nodal involvement and according to the different groups—stage I,II and III).Kaplan-Meier curves were also generated.The follow-up period is updated to May 2016.Results:Median follow-up period was 33 months and 45/89(51%)deaths from GC were observed.ADC was significantly different both for local invasion and nodal involvement(P<0.001).Considering final histology as the reference standard,a preoperative ADC cut-off of 1.80×10–3 mm2/s could distinguish between stages I and II and an ADC value of≤1.36×10–3 mm2/s was associated with stage III(P<0.001).Kaplan-Meier curves demonstrated that the survival rates for the three prognostic groups were significantly different according to final histology and ADC cut-offs(P<0.001).Conclusions:ADC is different according to local invasion,nodal involvement and the 7th TNM stage groups for GC,representing a potential,additional prognostic biomarker.The addition of DW-MRI could aid in the staging and risk stratification of GC. | Francesco Giganti Alessandro Ambrosi Damiano Chiari Elena Orsenigo Antonio Esposito Elena Mazza Luca Albarello Carlo Staudacher Alessandro Del Maschio Francesco De Cobelli | 2017 | Chinese Journal of Cancer Research2017，29，2： | 15 |
| 2 | Anti-inflammatory activity of an ethanolic Caesalpinia sappan extract in human chondrocytes and macrophages显示文摘 | Shengqian Q. Wu Miguel Otero Frank M. Unger Mary B. Goldring Ampai Phrutivorapongkul Catharina Chiari Alexander Kolb Helmut Viernstein Stefan Toegel | 2011 | Journal of Ethnopharmacology2011，，2： | 3 |
| 3 | Cretaceous tectonic evolution of the Neo-Tethys in Central Iran:Evidence from petrology and age of the Nain-Ashin ophiolitic basalts显示文摘The Nain and Ashin ophiolites consist of Mesozoic melange units that were emplaced in the Late Cretaceous onto the continental basement of the Central-East Iran microcontinent(CEIM).They largely consist of serpentinized peridotites slices;nonetheless,minor tectonic slices of sheeted dykes and pillow lavas-locally stratigraphically associated with radiolarian cherts-can be found in these ophiolitic melanges.Based on their whole rock geochemistry and mineral chemistry,these rocks can be divided into two geochemical groups.The sheeted dykes and most of the pillow lavas show island arc tholeiitic(IAT)affinity,whereas a few pillow lavas from the Nain ophiolites show calc-alkaline(CA)affinity.Petrogenetic modeling based on trace elements composition indicates that both IAT and CA rocks derived from partial melting of depleted mantle sources that underwent enrichment in subduction-derived components prior to melting.Petrogenetic modeling shows that these components were represented by pure aqueous fluids,or sediment melts,or a combination of both,suggesting that the studied rocks were formed in an arc-forearc tectonic setting.Our new biostratigraphic data indicate this arc-forearc setting was active in the Early Cretaceous.Previous tectonic interpretations suggested that the Nain ophiolites formed,in a Late Cretaceous backarc basin located in the south of the CEIM(the so-called Nain-Baft basin).However,recent studies showed that the CEIM underwent a counter-clockwise rotation in the Cenozoic,which displaced the Nain and Ashin ophiolites in their present day position from an original northeastward location.This evidence combined with our new data and a comparison of the chemical features of volcanic rocks from different ophiolites around the CEIM allow us to suggest that the Nain-Ashin volcanic rocks and dykes were formed in a volcanic arc that developed on the northern margin of the CEIM during the Early Cretaceous in association with the subduction,below the CEIM,of a Neo-Tethys oceanic branch that was existing between the CEIM and the southern margin of Eurasia.As a major conclusion of this paper,a new geodynamic model for the Cretaceous evolution of the CEIM and surrounding Neo-Tethyan oceanic basins is proposed. | Tahmineh Pirnia Emilio Saccani Ghodrat Torabi Marco Chiari Spela Gorican Edoardo Barbero | 2020 | Geoscience Frontiers2020，11，1： | 2 |
| 4 | Hemodynamic and analgesic effects of clonidine added repetitively to continuous epidural and spinal blocks显示文摘 | Klimscha W Chiari A Krafft P | 1995 | Anesth Analg1995，80，5： | 1 |
| 5 | Capillary electrophoresis investigation on the structure-enantioselectivity relationship in synthetic cyclopeptides as chiral selectors 显示文摘 | Marinzi C Longhi R Chiari M | 2001 | Electrophoresis2001，22，15： | 1 |
| 6 | Behavior of borderline tumors with particular interest to persistence,recurrence and progression to invasive carcinoma:a prospective study显示文摘 | Zanetta G Rota S Chiari S | 2001 | J Clin Oncl2001，19，10： | 1 |
| 7 | Behavior of borderline tumorswith particular interest to persistence,recurrence,and progressionto invasive carcinoma : a prospective study 显示文摘 | Zanetta G Kota S Chiari S | 2001 | J Clin Oncol2001，19，0： | 1 |
| 8 | Role of endothelial nitric oxide synthase as a trigger and mediator of isofiurane-induced delayed preconditioning in rabbit myocardium 显示文摘 | Chiari PC Bienengraeber MW Weihrauch D | 2005 | Anesthesiology2005，103，1： | 1 |
| 9 | Ueber die selbst ndige Phlebitis obliterans derHauptst mine der Venae hepaticae als Todesursache 显示文摘 | Chiari H | | Beitr Z Pathol Anat0，26，： | 1 |
| 10 | Impact of specific mutant KRAS on clinical outcome of EGFR-TKI-treated advanced non-small cell lung cancer patients with an EGFR wild type genotype显示文摘 | Metro G Chiari R Duranti S | 2012 | Lung Cancer2012，78，1： | 1 |
| 11 | Edge-to-edge mitral valve repair for isolated prolapse of the anterior leaflet caused by degenerative disease 显示文摘 | Fucei C Cieeo GD Chiari E | 2007 | J Cardiovase Ned ( Hagerstown )2007，8，5： | 1 |
| 12 | Leveraging on nanomechanical sensors to single out active small lig- ands for I]2-macroglobulin 显示文摘 | Oliviero G Chiari M Lorenzi E D | 2013 | Sensors and Actuators B: Chemical2013，176，： | 1 |
| 13 | Comparative performance of the 16S rRNA gene in DNA barcoding of amphibians显示文摘 | Vences M Thomas M van der Meijden A Chiari Y Vieites DR | | 0，，： | 1 |
| 14 | Desflurane-induced Preconditioning Alters Calcium-induced Mitochondrial Permeability Transition显示文摘 | Vincent Piriou Pascal Chiari Odile Gateau-Roesch Laurent Argaud Danina Muntean Delphine Salles Joseph Loufouat Pierre-Yves Gueugniaud Jean-Jacques Lehot Michel Ovize | 2004 | Anesthesiology2004，，3： | 1 |
| 15 | A portable audio-biofeedback system to improve postural control显示文摘 | Dozza M Chiari L Horak FB | 2004 | Conf Proc IEEE Eng Med Biol Soe2004，7，： | 1 |
| 16 | High-throughput mutationalscreening for beta-thalassemia by single-nucleotide extension显示文摘 | Galbiati S Chiari M Macellari M | 2007 | Electrophoresis2007，28，23： | 1 |
| 17 | Pharmacological preconditioning:comparison of desflurane,isoflurane,isoflurane and halothane in rabbitmyocardium显示文摘 | Piriou V Chiari P Lhuillier F | 2002 | Br J Anaesth2002，89，3： | 1 |
| 18 | Analgesic and hemodynamic effects of clonidine as the sole analgesic agent during first stage of labor:a dose-response study显示文摘 | Chiari A Lorber C Eisenach JC | 1999 | Anosthosiology1999，91，2： | 1 |
| 19 | Hepatitis B virus ( HBV ) - specific short hairpin RNA is capable of reducing the formation of HBV covalently closed circular ( CCC ) DNA but has no effect on established CCC DNA in vitro显示文摘 | Starkey JL Chiari EF Isom HC | 2009 | J Gen Virol2009，90，1： | 1 |
| 20 | High mitochondrial diversity within and among populations of Malagasy poison frogs显示文摘 | VENCES M CHIARI Y RAHARIVOLOLONIAINA L | 2004 | Molecular Phylogenetics and Evolution2004，30，： | 1 |
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