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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Genome-wide analysis of gene expression associated with MYCN in human neuroblastoma显示文摘 | Alaminos M Mora J Cheung NK Smith A Qin J Chen L Gerald WL | 2003 | Cancer Res2003，63，8： | 1 |
| 3 | Inhibition of myogenic bHLH and MEF2 transcriptionfactors by the bHLH protein Twist显示文摘 | Spicer DB Rhee J Cheung WL | 1996 | Science1996，272，5267： | 1 |
| 4 | Listeriosis complicating pregnancy显示文摘 | Cheung VY Sirkin WL | | 0，，11： | 1 |
| 5 | The prognostic significance of BMP-6 signaling in prostate cancer显示文摘 | Yuen HF Chan YP Cheung WL | | 0，，： | 1 |
| 6 | Impact of diabetes on coronary artery disease in women and men:a metaanalysis of prospective studies显示文摘 | Lee WL Cheung AM Cape D | 2000 | Diabetes Care2000，23，7： | 1 |
| 7 | Prognostic value of MYCN and ID2 overexpression in neuroblastoma显示文摘 | Alaminos M Gerald WL Cheung NK | 2005 | Pediatr Blood Cancer2005，45，7： | 1 |
| 8 | Agreement between periapical radiographs and cone-beam computed tomography for assessment of periapical status of root filled molar teeth显示文摘 | Cheung GS Wei WL McGrath C | 2013 | Int Endod J2013，46，10： | 1 |
| 9 | Impact of diabetes on cardiovascular disease in women and men: a meta-a- nalysis of prospective studies 显示文摘 | Lee WL Cheung AM Cape D | 2007 | Diabetes Care2007，23，7： | 1 |
| 10 | Increased genetic damage in oral leukoplakia from high risk sites: potential impact on staging and clinical management显示文摘 | Zhang L Cheung KJ Lam WL | 2001 | Cancer2001，91，11： | 1 |
| 11 | Impact of diabetes on coronary artery disease in women and men:a meta-analysis of prospective studies显示文摘 | Lee WL Cheung AM CaPe D | 2000 | Diabetes Care2000，23，： | 1 |
| 12 | Squamous cell carcinoma 0f the renal pelvis显示文摘 | Cheung WL | 1987 | J Urol1987，138，2： | 1 |
| 13 | In vitro chondrogenic differentiation of human mesenchymal stem cells in col agen microspheres:influence of cellseeding density and col agen concentration显示文摘 | Hui TY Cheung KM Cheung WL | | 0，，22： | 1 |
| 14 | Agreement between periapical radiographs and cone-beam computed tomography for assessment of periapical status of root filled molar teeth 显示文摘 | Cheung GS Wei WL McGrath C | 2013 | Int E ndod J2013，46，10： | 1 |
| 15 | Squamous cell carcinoma of the renal pelvis显示文摘 | Li MK Cheung WL | 1987 | J Urol1987，138，2： | 1 |
| 16 | Antifungal and anti- viral products of marine organisms显示文摘 | Cheung RC Wong JH Pan WL | 2014 | Appl Microbiol Bio- techno12014，98，8： | 1 |
| 17 | Impact of dia- betes on coronary artery disease in women and men: a meta- analysis of prospective studies显示文摘 | Lee WL Cheung AM Cape D | 2000 | Diabetes Care2000，23，7： | 1 |
| 18 | Squamous cell carcinoma of the renal pelvis显示文摘 | Li MK Cheung WL | 1987 | J Urol1987，138，2： | 1 |
| 19 | Listeriosis complicating pregnancy显示文摘 | CHEUNG VY SIRKIN WL | 2009 | CMAJ2009，181，11： | 1 |
| 20 | Prognostic value of MYCNand ID2 overexpression in neuroblastoma显示文摘 | Alaminos M Gerald WL Cheung NK | 2005 | Pediatr Blood Cancer2005，45，7： | 1 |
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