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| 1 | Painful intervertebral disc degeneration and inflammation:from laboratory evidence to clinical interventions显示文摘Low back pain(LBP),as a leading cause of disability,is a common musculoskeletal disorder that results in major social and economic burdens.Recent research has identified inflammation and related signaling pathways as important factors in the onset and progression of disc degeneration,a significant contributor to LBP.Inflammatory mediators also play an indispensable role in discogenic LBP.The suppression of LBP is a primary goal of clinical practice but has not received enough attention in disc research studies.Here,an overview of the advances in inflammation-related pain in disc degeneration is provided,with a discussion on the role of inflammation in IVD degeneration and pain induction.Puncture models,mechanical models,and spontaneous models as the main animal models to study painful disc degeneration are discussed,and the underlying signaling pathways are summarized.Furthermore,potential drug candidates,either under laboratory investigation or undergoing clinical trials,to suppress discogenic LBP by eliminating inflammation are explored.We hope to attract more research interest to address inflammation and pain in IDD and contribute to promoting more translational research. | Feng-Juan Lyu Haowen Cui Hehai Pan Kenneth MC Cheung Xu Cao James C.Iatridis Zhaomin Zheng | 2021 | Bone Research2021，9，1： | 24 |
| 2 | TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory显示文摘 | Lai KO Wong AS Cheung MC | 2012 | Nat Neurosci2012，15，11： | 1 |
| 3 | Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization显示文摘 | Chan JY Cheung MC Moi P | | 0，，03： | 1 |
| 4 | Venous thromboem- bolism and nonsmall cell lung cancer: a pooled analysis of Na- tional Cancer Institute of Canada Clinical Trials Group trials显示文摘 | HICKS LK CHEUNG MC DING K | 2009 | Cancer2009，115，23： | 1 |
| 5 | A prospective randomized controlled trial on ureteral stenting after ureterscopic holmium laser lithotripsy显示文摘 | Cheung MC Lee F Leung YL | 2003 | J Urol2003，169，4： | 1 |
| 6 | Prenatal diagnosis of sickle cell anemia and thalassaemia by analysis of fetal cells in maternal blood显示文摘 | Cheung MC Janes D Kan YW | 1996 | Nat Genet1996，14，3： | 1 |
| 7 | Survival disparitiesin newborns with congenital diaphragmatic hernia: a nationalperspective显示文摘 | Sola JE Bronson SN Cheung MC | 2010 | J Pediatr Surg2010，45，： | 1 |
| 8 | Percutaneous Lavage as primary treatment for infected pancreatic necrosis显示文摘 | Sleeman D Levi DM Cheung MC | 2011 | J Am Coll Surg2011，212，4： | 1 |
| 9 | Altered association of protein tyrosine kinases with postsynaptic densities after transient cerebral ischemiain the rat brain显示文摘 | Cheung HH Takagi N Teves L Logan R Wallace MC Gurd JW | 2000 | J Cereb Blood Flow Metab2000，20，3： | 1 |
| 10 | Executive function deficits and neural discordance in children with autism spectrum disorders 显示文摘 | Chan AS Cheung MC Han YM | 2009 | Clin Neurophysiol2009，120，6： | 1 |
| 11 | Time profile of appearance and disappearance of circulating placenta-derived mRNA in maternal plasma显示文摘 | Chiu RWK Lui WB Cheung MC | | 0，，： | 1 |
| 12 | Selective adherence of IgA to murine Peyer's patch M cells: evidence for a novel IgA receptor显示文摘 | Mantis NJ Cheung MC Chintalacharuvu KR | 2002 | J Immunol2002，169，4： | 1 |
| 13 | A prosepective randomized controlled trial on ureteral stenting after ureteroscopic holmium laser lithotripsy显示文摘 | Cheung MC Lee F Leung YL | 2003 | J Urol2003，169，4： | 1 |
| 14 | Primary gastrointes- tinal tract lymphoma in the pediatric patient: review of 265 pa- tients from the SEER registry显示文摘 | Kassira N Pedroso FE Cheung MC | 2011 | J Pediatr Surg2011，46，19： | 1 |
| 15 | Impact of central nervous system (CNS) prophylaxis on the incidence and risk factors for CNS relapse in patients with diffuse large B-cell lymphoma treated in the rituximab era: a single centre experience and review of the literature显示文摘 | Guirguis HR Cheung MC Mahrous M | 2012 | Br J Haematol2012，159，1： | 1 |
| 16 | Seven-proves language and social inter- action of children with autistic spectrum disorders显示文摘 | Chan AS Cheung MC Sze SL | 2009 | The American Jourual of Chinese Medicine2009，37，3： | 1 |
| 17 | Apolipoprotein E affects the amount, form, and anatomical distribution of amy loid beta-peptide deposition in homozygous APP (V717F) transgenic mice显示文摘 | Cheung BS Rebeck GW | 2000 | Acta Neuropathol2000，100，： | 1 |
| 18 | Music training improves verbal memory 显示文摘 | Chan AS Ho YC Cheung MC | 1998 | Nature1998，396，： | 1 |
| 19 | Incidence and outcomes of extremity soft-tissue sarcomas in children显示文摘 | Cheung MC Zhuge Y Yang R | 2010 | J Surg Res2010，163，2： | 1 |
| 20 | Primary gastrointestinaltract lymphoma in the pediatric patient : review of 265 patientsfrom the SEER registry显示文摘 | Kassira N Pedroso FE Cheung MC | 2011 | J Pediatr Surg2011，46，10： | 1 |
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