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| 1 | Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33:implications for allergic inflammation显示文摘The novel interleukin(IL)-1 family cytokine IL-33 has been shown to activate T helper 2(Th2)lymphocytes,mast cells and basophils to produce an array of proinflammatory cytokines,as well as to mediate blood eosinophilia,IgE secretion and hypertrophy of airway epithelium in mice.In the present study,we characterized the activation of human eosinophils by IL-33,and investigated the underlying intracellular signaling mechanisms.IL-33 markedly enhanced eosinophil survival and upregulated cell surface expression of the adhesion molecule intercellular adhesion molecule(ICAM)-1 on eosinophils,but it suppressed that of ICAM-3 and L-selectin.In addition,IL-33 mediates significant release of the proinflammatory cytokine IL-6 and the chemokines CXCL8 and CCL2.We found that IL33-mediated enhancement of survival,induction of adhesion molecules,and release of cytokines and chemokines were differentially regulated by activation of the nuclear factor(NF)-KB,p38 mitogen-activated protein kinase(MAPK)and extracellular signal-regulated kinase(ERK)pathways.Furthermore,we compared the above IL-33 activities with two structurally and functionally related cytokines,IL-1 B and IL-18.IL-1β,but not IL-18,markedly upregulated cell surface expression of ICAM-1.IL-1βand IL-18 also significantly enhanced eosinophil survival,and induced the release of IL-6 and chemokines CXCL8 and CCL2 via the activation of the NF-κB,p38 MAPK and ERK pathways.Synergistic efects on the release of IL-6 were also observed in combined treatment withIL-1B,IL-18 and IL-33.Taken together,our findings provide insight into IL-33-mediated activation of eosinophils via differential intracellular signaling cascades in the immunopathogenesis of allergic inflammation. | Joyce YS Chow Chun K Wong Phyllis FY Cheung Christopher WK Lam | 2010 | Cellular & Molecular Immunology2010，7，1： | 22 |
| 2 | A population-based analysis of inci-dence,mortality,and stage-specific survival of cervical cancer patients inHong Kong:1997-2006显示文摘 | Cheung FY Mang OWK Law SC | 2011 | Hong Kong Med J2011，17，2： | 1 |
| 3 | Survivinbiology and potential as a therapeutic target in oncology显示文摘 | Cheung CH Huang CC Tsai FY | 2013 | Onco Targets Ther2013，6，10： | 1 |
| 4 | Survivin- biology and potential as a therapeutic target in oncology显示文摘 | Cheung CH Huang CC Tsai FY | 2013 | Onto Targets Ther2013，6，： | 1 |
| 5 | A multicenter phase II study of sorafenib, capecitabine, and oxaliplatin ( SECOX) in patients with advanced hepatocellular carcinoma: final results of Hong Kong-Singapore Hepatocellular Carcinoma Research Collaborative Group study显示文摘 | Yau TC Cheung FY Lee F | 2013 | J Clin Oncol2013，，： | 1 |
| 6 | Survivin-biology and potential as a therapeutic target in oncology显示文摘 | Cheung CH Huang CC Tsai FY | 2013 | Onco Targets Ther2013，16，6： | 1 |
| 7 | Survivin-biology and potential as a therapeutic target in oncology 显示文摘 | Cheung CH Huang CC Tsai FY | 2013 | Onco Targets Ther2013，6，： | 1 |
| 8 | Applications of exogenous mesenchymal stem cells and low intensity pulsed ultrasound enhance fracture healing in rat model 显示文摘 | Cheung WH Chin WC Wei FY | 2013 | Ultrasound Med Biol2013，39，： | 1 |
| 9 | Bilateral substantia nigra and pyramidal tract changes following experimental intracerebral hemorrhage:an MR diffusion tensor imaging study显示文摘 | Fan SJ Lee FY Cheung MM | 2013 | NMR in Biomedicine2013，26，9： | 1 |
| 10 | Survivin-biology and potential as a therapeutic target in oncology 显示文摘 | Cheung CH Huang CC Tsai FY | 2013 | Onco Targets Ther2013，6，： | 1 |
| 11 | Survivin-biology and potential as a therapeutic target in oncology 显示文摘 | Cheung CH Huang CC Tsai FY | 2013 | Onco TargetsTher2013，6，： | 1 |
| 12 | Survivin-biology and potential as a therapeutic target in oncology显示文摘 | Cheung CH Huang CC Tsai FY | 2013 | Onco Targets Ther2013，6，： | 1 |
| 13 | Transformational leadership,leader support,and employee creativity显示文摘 | Cheung M FY Wong CS | | 0，，07： | 1 |
| 14 | Mechanisms of the vasorelaxant effect of Danshen (Salvia mihiorrhiza) in rat knee joints显示文摘 | Lam FY Ng SCW Cheung JHY | 2006 | J Ethnopharmacol2006，1114，1： | 1 |
| 15 | Phase Ⅱ trial of sorafenib with capecitabine and oxaliplatin (SECOX) in patients with locally advanced or metastatic hepatocellular carcinoma显示文摘 | Yau T Chan P Cheung FY | 2009 | European Journal of Cancer2009，7，3： | 1 |
| 16 | A population-based analysis of incidence,mortality, aud stage-specific survival of cervical cancer patients in Hong Kong:1997-2006显示文摘 | Cheung FY Mang OW Law SC | 2011 | Hong Kong Med J2011，2，17： | 1 |
| 17 | A population-based analysis of incidence,mortality, and stage-specific survival of cervical cancer patients in Hong Kong:1997-2006显示文摘 | Cheung FY Mang OW Law SC | 2011 | Hong Kong Med J2011，2，17： | 1 |
| 18 | Amelioration of experimental colitis by Astragalus membranaeeus thmulgh anti--oxidation and inhibition of adhesion molecuh synthesis 显示文摘 | Ko JK Lain FY Cheung AP | 2005 | World J Gastroen- tero12005，11，37： | 1 |
| 19 | Survivinbiology and potential as a therapeutic target in oncology显示文摘 | Cheung CH Huang CC Tsai FY | 2013 | Onco Targets Ther2013，6，： | 1 |
| 20 | A population-based analysis of incidence,mortality and stage-specific survival of cervical cancer patients in Hong Kong: 1997-2006显示文摘 | Cheung FY Mang OW Law SC | 2011 | Hong Kong Med J2011，2，17： | 1 |
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