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| 1 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 2 | Thermal Energy-Driven Solid-State Molecular Rotation Monitored by Real-Time Emissive Color Switching显示文摘Inspired by nature’s molecular machines,the scientific research on solid-state molecular rotors is of great interest yet remains largely unexplored.Herein,we report a unique example of a thermal energydriven stimuli-responsive solid-state molecular rotor,which features an o-carborane moiety as a rotor that directly transduces the surrounding thermal energy into molecular rotations in the crystalline state.Its rotation is confirmed by X-ray diffraction. | Junfeng Li Chenxi Hou Qi Qi Lin Jiao Lanqing Dai Dong Chen Haigang Geng Wen-Yong Lai Wei Huang | 2022 | CCS Chemistry2022，4，8： | 2 |
| 3 | A high-order curvature-corrected CMOS bandgap voltage reference with constant current technique 显示文摘 | Geng Junfeng Zhao Yiqiang Zhao Hongliang | 2012 | International Journal of Circuit Theory and Applications2012，42，1： | 1 |
| 4 | Effective removal of Cd^2+ and Pb^2+ pollutants from wastewater by dielectrophoresis-assisted adsorption显示文摘Dielectrophoresis(DEP)was combined with adsorption(ADS)to simultaneously and effectively remove Cd^2+ and Pb^2+ species from aqueous solution.To implement the process,bentonite particles of submicro-meter size were used to first adsorb the heavy metal ions.These particles were subsequently trapped and removed by DEP.The effects of the adsorbent dosage,DEP cell voltage and the capture pool numbers on the removal rate were investigated in batch processes,which allowed us to determine the optimal experimental conditions.The high removal efficiency,97.3% and 99.9% for Cd^2+ and Pb^2+,respectively,were achieved when the ions are coexisting in the system.The microstructure of bentonite particles before and after ADS/DEP was examined by scanning electron microscopy.Our results suggest that the dielectrophoresis-assisted adsorption method has a high capability to remove the heavy metals from wastewater. | Qinghao Jin Chenyang Cui Huiying Chen Jing Wu Jing Hu Xuan Xing Junfeng Geng Yanhong Wu | 2019 | Frontiers of Environmental Science & Engineering2019，13，2： | 1 |
| 5 | A new strategy for fabrication of unique heterostructured titanium laminates and visually tracking their synchronous evolution of strain partitions versus microstructure显示文摘Heterostructured(HS)material with extraordinary mechanical properties has been regarded as one of the most promising structural materials.Here,we reported a new strategy for preparing heterostructured pure titanium laminates that possess a good combination of strength and ductility by combining gradient structure(GS)and heterogeneous lamella structure(HLS).The deformation characteristic versus microstructure evolution of GS/HLS titanium laminates,namely the strain partitions between different-sized grains(480–25μm)was visualized using a scanning electron microscope(SEM)equipped with electron backscattered diffraction(EBSD)mode combined with the digital image correlation(SEM-DIC)with an ultrahigh spatial resolution for the first time.As a result,the hetero-deformation of unique GS/HLS structure by the characteristic of strain partitions could be accurately captured.While the hetero-deformation could result in the hetero-deformation induced(HDI)stress strengthening and HDI hardening,which were regarded as the key reason that the resulting GS/HLS Ti laminates showed a superior combination of strength and ductility.This could promote a more in-depth understanding of the strengtheningtoughening mechanism of heterostructured material. | Hao Ding Xiping Cui Zhiqi Wang Tao Zhao Yuchen Wang Yuanyuan Zhang Hongtao Chen Lujun Huang Lin Geng Junfeng Chen | 2022 | Journal of Materials Science & Technology2022，，12： | 1 |
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