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您的检索式：作者名="Chengnan Yan"
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| 1 | Recent advances in hydrogel-based anti-infective coatings显示文摘Bacterial infections associated with biomedical devices and implants have posed a great challenge to global healthcare systems.These infections are mainly caused by bacterial biofilm formed on the surface of biomaterials,protecting the encapsulated bacteria from conventional antibiotic treatment and attack of the immune system.As the bacterial biofilm is difficult to eradicate,bactericidal and antifouling coatings have emerged as promising strategies to prevent biofilm fo rmation and subsequent infections.Hydrogels with three-dimensional crosslinked hydrophilic networks,tunable mechanical property and large drugloading capacity are desirable coating materials,which can kill bacteria and/or prevent bacterial adhesion on the surface,inhibiting biofilm formation.Herein,we review recent developments of hydrogels as anti-infective coatings.Particularly,we highlight two chemical approaches(graft-from and graft-to),which have been used to immobilize hydrogels on surfaces,and present advances in the development of bactericidal(contact-killing and antimicrobial-releasing),antifouling(hydrophilic polymer network)and bifunctional hydrogel coatings with both bactericidal and antifouling activities.In addition,the challe nges of hydrogel coatings for clinical applications are discussed,and future research directions of anti-infective hydrogel coatings are proposed. | Mengjing Fu Yijing Liang Xue Lv Chengnan Li Yi Yan Yang Peiyan Yuan Xin Ding | 2021 | Journal of Materials Science & Technology2021，，26： | 1 |
| 2 | Brain-targeted polymersome codelivery of siRNA and temozolomide for effective glioblastoma chemo-RNAi synergistic therapy显示文摘Temozolomide (TMZ) is a clinically approved drug for glioblastoma (GBM) therapy. However, as a result of methylguanine-DNA-methyltransferase (MGMT), which is able to repair damaged DNA-damage repairing, TMZ usually yields unsatisfactory therapeutic effects. Small interfering RNA (siRNA) is a potential alteration tool for sensitivity of TMZ by targeting DNA repair enzymes. However, a suitable TMZ and siRNA codelivery system that can effectively and actively co-deliver siRNA/TMZ into the brain tumor is lacking. In this study, we constructed an angiopep-2 decorated polymersomal delivery system to co-deliver TMZ/siRNA for synergistic GBM therapy. This targeted polymersomal nanomedicine not only enhanced the circulation time of siRNA/TMZ in blood but also improved their blood-brain barrier (BBB) crossing and GBM targeting ability. Moreover, when we co-administered siRNAs specific to retinoblastoma binding protein 4 (RBBP4) together with TMZ in GBM cells, these RBBP4- specific siRNA (siRBBP4) modulated the sensitivity of TMZ by regulating MGMT, and thus showed a powerful synergistic anti-tumor effect. We demonstrated that angiopep-2 decorated polymersomal siRBBP4/TMZ co-loaded nanomedicines are capable of inhibiting tumor growth and significantly improved life expectancy of orthotropic GBM bearing mice. Overall, our study suggests that such a polymersomal TMZ/siRNA codelivery system provides a robust and potent nanoplatform for targeted GBM chemo-RNAi therapy. | Meng Zheng Chengnan Yan Qingshan Yang Feiyan Zhu Qiuli Du Xue Xia Marco Morsch Albert Lee Jinglong Yin Yan Zou Bingyang Shi | 2022 | ChemPhysMater2022，1，3： | 0 |
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