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| 1 | Microstructure, biodegradation, antibacterial and mechanical properties of ZK60-Cu alloys prepared by selective laser melting technique显示文摘Magnesium(Mg) alloys are receiving increasing attention for body implants owing to their good biocompatibility and biodegradability. However, they often suffer from bacterial infections on account of their insufficient antibacterial ability. In this study, ZK60-x Cu(x = 0, 0.2, 0.4, 0.6 and 0.8 wt%) alloys were prepared by selective laser melting(SLM) with alloying copper(Cu) to enhance their antibacterial ability.Results showed that ZK60-Cu alloys exhibited strong antibacterial ability due to combination of release of Cu ions and alkaline environment which could kill bacteria by destroying cellular membrane structure,denaturing enzymes and inhibiting deoxyribonucleic acid(DNA) replication. In addition, their compressive strength increased due to grain refinement and uniformly dispersing of short-bar shaped MgZnCu phases. Moreover, ZK60-Cu alloys also exhibited good cytocompatibility. In summary, ZK60-Cu alloys with antibacterial ability may be promising implants for biomedical applications. | Cijun Shuai Long Liu Mingchun Zhao Pei Feng Youwen Yang Wang Guo Chengde Gao Fulai Yuan | 2018 | Journal of Materials Science & Technology2018，34，10： | 12 |
| 2 | The elemental carbon record in Weinan loess section since the last 21 ka显示文摘We studied the records of elemental carbon (EC) of the last 21 ka in the Weinan loess section, Shanxi Province. The variations of EC abundance and δ13CEC value along with depth (or age) were presented. There are four large peaks of EC abundance around the following years: 20.16 ka, 17.76 ka, 11.97 ka and 4.49 ka. Climatic situation was changed rapidly during these periods. The peaks around 11.97 ka and 20.16 ka are particularly sharp, occurring over intervals of tens to hundreds of years, which could represent short-duration intense events. δ13CEc values in the upper 4 m of the Weinan loess section vary between -11.71‰ and -21.34‰, which suggests that the vegetation pattern of the last 21 ka on the Loess Plateau is G4-dominated grasses. | YANG Ying SHEN Chengde YI Weixi SUN Yanmin LIU Dongsheng | 2001 | Chinese Science Bulletin2001，46，18： | 5 |
| 3 | Numerical studies of static aeroelastic effects on grid fin aerodynamic performances显示文摘The grid fin is an unconventional control surface used on missiles and rockets. Although aerodynamics of grid fin has been studied by many researchers, few considers the aeroelastic effects.In this paper, the static aeroelastic simulations are performed by the coupled viscous computational fluid dynamics with structural flexibility method in transonic and supersonic regimes. The developed coupling strategy including fluid–structure interpolation and volume mesh motion schemes is based on radial basis functions. Results are presented for a vertical and a horizontal grid fin mounted on a body. Horizontal fin results show that the deformed fin is swept backward and the axial force is increased. The deformations also induce the movement of center of pressure, causing the reduction and reversal in hinge moment for the transonic flow and the supersonic flow,respectively. For the vertical fin, the local effective incidences are increased due to the deformations so that the deformed normal force is greater than the original one. At high angles of attack, both the deformed and original normal forces experience a sudden reduction due to the interference of leeward separated vortices on the fin. Additionally, the increment in axial force is shown to correlate strongly with the increment in the square of normal force. | Chengde HUANG Wen LIU Guowei YANG | 2017 | Chinese Journal of Aeronautics2017，30，4： | 4 |
| 4 | Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout显示文摘 | Dong, Zheng Li, Yuan Zhou, Jingru Jiang, Shuai Wang, Yi Chen, Yulin Zhao, Dongbao Yang, Chengde Qian, Qiaoxia Ma, Yanyun He, Hongjun Ji, Hengdong Yang, Yajun Wang, Xiaofeng Xu, Xia Pang, Yafei Zou, Hejian Jin, Li Zhang, Feng Wang, Jiucun | 2017 | Protein & Cell2017，8，6： | 3 |
| 5 | Physical stimulations and their osteogenesis-inducing mechanisms显示文摘Physical stimulations such as magnetic,electric and mechanical stimulation could enhance cell activity and promote bone formation in bone repair process via activating signal pathways,modulating ion channels,regulating bonerelated gene expressions,etc.In this paper,bioeffects of physical stimulations on cell activity,tissue growth and bone healing were systematically summarized,which especially focused on their osteogenesis-inducing mechanisms.Detailedly,magnetic stimulation could produce Hall effect which improved the permeability of cell membrane and promoted the migration of ions,especially accelerating the extracellular calcium ions to pass through cell membrane.Electric stimulation could induce inverse piezoelectric effect which generated electric signals,accordingly up-regulating intracellular calcium levels and growth factor synthesis.And mechanical stimulation could produce mechanical signals which were converted into corresponding biochemical signals,thus activating various signaling pathways on cell membrane and inducing a series of gene expressions.Besides,bioeffects of physical stimulations combined with bone scaffolds which fabricated using 3D printing technology on bone cells were discussed.The equipments of physical stimulation system were described.The opportunities and challenges of physical stimulations were also presented from the perspective of bone repair. | Cijun Shuai Wenjing Yang Shuping Peng Chengde Gao Wang Guo Yuxiao Lai Pei Feng | 2018 | International Journal of Bioprinting2018，4，2： | 3 |
| 6 | Dual alloying improves the corrosion resistance of biodegradable Mg alloys prepared by selective laser melting显示文摘Mg alloys have been regarded as revolutionary metallic biomaterials for biodegradable bone implants,but their applications are mainly blocked by the too rapid degradation in physiological environment.This study explores the dual alloying effects of Mn and/or Sn on the performance of Mg alloys prepared by selective laser melting.The observed microstructure indicated remarkable refinement of both the grains and intermetallic phases in the Mn-and/or Sn-containing alloys during the rapid solidification process.Moreover,approximately a half decrease in corrosion rate was observed for AZ61-0.4Mn-0.8Sn alloy with respect to AZ61 alloy.The improved corrosion behavior was primarily due to the enhanced protective effects of surface layers,in which Mn-and/or Sn-rich phases acted as a helpful barrier against medium penetration and thereby alleviated the current exchange with the matrix.In addition,the solute Mn and/or Sn positively shifted the corrosion potential,which also brought about a better corrosion resistance.Furthermore,the strength and hardness of the alloys were also effectively improved and comparable to those of cortical bone.This could be ascribed to the dissolved Mn and/or Sn atoms and the finely dispersed intermetallic phases,which might cause lattice distortion and precipitation hardening.Besides,the Mn-and/or Sn-containing alloys showed good cytocompatibility as indicated by the normal morphology and increased viability of MG-63 cells.These findings suggest that the developed AZ61-Mn-Sn alloy is a promising candidate for biodegradable bone implants. | Chengde Gao Sheng Li Long Liu Shizhen Bin Youwen Yang Shuping Peng Cijun Shuai | 2021 | Journal of Magnesium and Alloys2021，9，1： | 3 |
| 7 | A biomass burning record from the Lingtai Loess Section during the last 370 ka and implication for climate and environment显示文摘The history of natural fire and its rela- tionship with climate and vegetation are revealed from the content of elemental carbon and associated pollen data and paleoclimatic substitutive indicators for the loess of Lingtai Section in the last 370 ka BP. The study indicates that intense episodes of vegeta- tion fires occurred during the interim especially when the climate was changing from wet to drought. The average content of elemental carbon in the intergla- ciers is higher than that in the glaciers, which coin- cides with the biomass change locally (or globally). The content of elemental carbon increases in the stage around 130 ka BP, indicating that the vegeta- tion and climate pattern have changed, which may contribute to the variation of CO2. As a whole, the content of elemental carbon increasing with the time reflects the increasing aridity trend to some degree. In addition, the occurrence of the maximum peak and the highest average content of elemental carbon in the Holocene reflects the occurrence of a rapid cli- mate event in 5900 a BP and more frequent fires caused by anthropic activities. | ZHOU Bin SHEN Chengde SUN Yanmin YANG Ying YI Weixi | 2006 | Chinese Science Bulletin2006，51，17： | 2 |
| 8 | Mechanism for corrosion protection of β-TCP reinforced ZK60 via laser rapid solidification显示文摘It remains the primary issue to enhance the corrosion resistance of Mg alloys for their clinical applications.In this study,β-tricalcium phosphate(β-TCP)was composited with Mg-6Zn-1Zr(ZK60)using laser rapid solidification to improve the degradation behavior.Results revealed rapid solidification effectively restrained the aggregation ofβ-TCP,which thus homogenously distributed along grain boundaries ofα-Mg.Significantly,the uniformly distributedβ-TCP in the matrix promoted the formation of apatite layer on the surface,which contributed to the formation of a compact corrosion product layer,hence retarding the further degradation.Furthermore,ZK60/8β-TCP(wt.%)composite showed improved mechanical strength,as well as improved cytocompatibility.It was suggested that laser rapidly solidified ZK60/8β-TCP composite might be a potential materials for tissue engineering. | Youwen Deng Youwen Yang Chengde Gao Pei Feng Wang Guo Chongxian He Jian Chen Cijun Shuai | 2018 | International Journal of Bioprinting2018，4，1： | 2 |
| 9 | An nMgO containing scaffold:Antibacterial activity,degradation properties and cell responses显示文摘Bone repair failure caused by implant-related infections is a common and troublesome problem.In this study,an antibacterial scaffold was developed via selective laser sintering with incorporating nano magnesium oxide(nMgO)to poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV).The results indicated the scaffold exerted high antibacterial activity.The antibacterial mechanism was that nMgO could cause oxidative damage and mechanical damage to bacteria through the production of reactive oxygen species(ROS)and direct contact action,respectively,which resulted in the damage of their structures and functions.Besides,nMgO significantly increased the compressive properties of the scaffold including strength and modulus,due to its excellent mechanical properties and uniform dispersion in the PHBV matrix.Moreover,the degradation tests indicated nMgO neutralized the acid degradation products of PHBV and benefited the degradation of the scaffold.The cell culture demonstrated that nMgO promoted the cellular adhesion and proliferation,as well as osteogenic differentiation.The present work may open the door to exploring nMgO as a promising antibacterial material for tissue engineering. | Cijun Shuai Wang Guo Chengde Gao Youwen Yang Ping Wu Pei Feng | 2018 | International Journal of Bioprinting2018，4，1： | 1 |
| 10 | Additive manufacturing of bone scaffolds显示文摘Additive manufacturing(AM)can obtain not only customized external shape but also porous internal structure for scaffolds,both of which are of great importance for repairing large segmental bone defects.The scaffold fabrication process generally involves scaffold design,AM,and post-treatments.Thus,this article firstly reviews the state-of-the-art of scaffold design,including computer-aided design,reverse modeling,topology optimization,and mathematical modeling.In addition,the current characteristics of several typical AM techniques,including selective laser sintering,fused deposition modeling(FDM),and electron beam melting(EBM),especially their advantages and limitations are presented.In particular,selective laser sintering is able to obtain scaffolds with nanoscale grains,due to its high heating rate and a short holding time.However,this character usually results in insufficient densification.FDM can fabricate scaffolds with a relative high accuracy of pore structure but with a relative low mechanical strength.EBM with a high beam-material coupling efficiency can process high melting point metals,but it exhibits a low-resolution and poor surface quality.Furthermore,the common post-treatments,with main focus on heat and surface treatments,which are applied to improve the comprehensive performance are also discussed.Finally,this review also discusses the future directions for AM scaffolds for bone tissue engineering. | Youwen Yang Guoyong Wang Huixin Liang Chengde Gao Shuping Peng Lida Shen Cijun Shuai | 2019 | International Journal of Bioprinting2019，5，1： | 1 |
| 11 | Modification of Norditerpenoid Alkaloids:Ⅱ.A Simple andConvenient Preparation of the Imine Derivatives of Norditerpenoid Alkaloids显示文摘Treatment of 3-acetylpseudaconie 6 and 3. 13-diacetylyunnaconitine 9 withNBS/acetone-H2O(2:1) at room temperature produced corresponding imine derivatives & and 10.respectively. in good yields. This is a novel simple and convenient method for preparation of theimine compounds. | Feng Peng WANG Zheng Bang LI Jin Song YANG and Bo Gang LI(Department of Chemistry of Medicinal Natural Products School of PharmacyWest China University of Medical Sciences. Chengdu 610041 Chengdu Institute of Biology. Chinese Academy of Sciences. Chengd | 1999 | Chinese Chemical Letters1999，10，6： | 1 |
| 12 | A multi-scale porous scaffold fabricated by a combined additive manufacturing and chemical etching process for bone tissue engineering显示文摘It is critical to develop a fabrication technology for precisely controlling an interconnected porous structure of scaffolds to mimic the native bone microenvironment.In this work,a novel combined process of additive manufacturing(AM)and chemical etching was developed to fabricate graphene oxide/poly(L-lactic acid)(GO/PLLA)scaffolds with multiscale porous structure.Specially,AM was used to fabricate an interconnected porous network with pore sizes of hundreds of microns.And the chemical etching in sodium hydroxide solution constructed pores with several microns or even smaller on scaffolds surface.The degradation period of the scaffolds was adjustable via controlling the size and quantity of pores.Moreover,the scaffolds exhibited surprising bioactivity after chemical etching,which was ascribed to the formed polar groups on scaffolds surfaces.Furthermore,GO improved the mechanical strength of the scaffolds. | Cijun Shuai Youwen Yang Pei Feng Shuping Peng Wang Guo Anjie Min Chengde Gao | 2018 | International Journal of Bioprinting2018，4，2： | 1 |
| 13 | Effect of synthetical conditions, morphology, and crystallographic structure of MnO2 on its electrochemical behavior显示文摘 | Yujuan Yang Chengde Huang | 2010 | Journal of Solid State Electrochemistry2010，，7： | 1 |
| 14 | Processable Potassium Metal Anode for Stable Batteries显示文摘The future of high-energy density electrochemical energy storage systems relies on the advancement of rechargeable batteries that utilize reactive metals as anodes.In the alkaline metal,secondary battery systems because of abundant resource,high capacity and low redox potential,potassium(K)metal secondary battery(KMB)is expected to replace the existing lithiumion battery as a versatile platform for high-energy density,cost-effective energy storage devices.However,the difficulty in processing metal K results in nonstandard electrodes and hinders the development of KMBs.Furthermore,the mobility of the K metal anode due to its unique lowmelting point character at elevated temperatures in practical conditions leads to severe instability and risks in chemical/electrochemical processes.Herein,we fabricate a processable and moldable composite K metal anode by encapsulating K into reduced graphene oxide(rGO).The composite electrode can be engineered into various shapes discretionarily with precise sizes and stabilize the K metal anode at relatively high temperatures.Remarkably,the composite anode exhibits excellent cycling performance at high current density(8 mA cm^(-2)) with dendrite-free morphology.Paired with a Prussian blue cathode,the rGO-K composite anode shows much improved electrochemical performance and extended lifetime. | Zhenghang Wei Aoxuan Wang Xuze Guan Guojie Li Zhiwei Yang Chengde Huang Jing Zhang Libin Ren Jiayan Luo Xingjiang Liu | 2022 | Energy & Environmental Materials2022，5，4： | 0 |
| 15 | Selenium Enriched Trionyx sinensis : A New Choice for the Sustainable Development Model of Modern Agriculture显示文摘Based on the analysis of the current situation and existing problems of traditional Chinese soft shelled turtle(Trionyx sinensis)breeding industry,combined with the fact that selenium enriched functional agriculture is the future demand of mankind,this paper put forward the necessity of developing selenium enriched Chinese soft shelled turtles and promoting the sustainable development of modern agriculture:the development of selenium-enriched Chinese soft-shelled turtle is the need of the consumer market for food safety,the need to reduce the production cost of soft-shelled turtles and improve the production efficiency of soft-shelled turtles,the need to enrich the Chinese soft-shelled turtle market,and the need to promote the sustainable development of modern agriculture(fishery). | Bo YANG Wei HUANG Xianghui QIN Jun YAN Chengde LIN Xiaofeng GAO Yinglan HUANG | 2021 | Agricultural Biotechnology2021，10，6： | 0 |
| 16 | An in-situ spectroscopy investigation of alkali metal interaction mechanism with the imide functional group显示文摘Organic anode materials have attracted considerable interest owing to their high tunability by adopting various active functional groups.However,the interaction mechanisms between the alkali metals and the active functional groups in host materials have been rarely studied systematically.Here,a widely used organic semiconductor of perylene-3,4,9,10-tetracarboxylic diimide(PTCDI)was selected as a model system to investigate how alkali metals interact with imide functional groups and induce changes in chemical and electronic structures of PTCDI.The interaction at the alkali/PTCDI interface was probed by in-situ X-ray photoelectron spectroscopy(XPS),ultraviolet photoelectron spectroscopy(UPS),synchrotron-based near edge X-ray absorption fine structure(NEXAFS),and corroborated by density functional theory(DFT)calculations.Our results indicate that the alkali metal replaces the hydrogen atoms in the imide group and interact with the imide nitrogen of PTCDI.Electron transfer induced gap states and downward band-bending like effects are identified on the alkali-deposited PTCDI surface.It was found that Na shows a stronger electron transfer effect than Li.Such a model study of alkali insertion/intercalation in PTCDI gives insights for the exploration of the potential host materials for alkali storage applications. | Xu Lian Zhirui Ma Zhonghan Zhang Jinlin Yang Shuo Sun Chengding Gu Yuan Liu Honghe Ding Jun Hu Xu Cao Junfa Zhu Shuzhou Li Wei Chen | 2020 | Nano Research2020，13，12： | 0 |
| 17 | Presence of multiple abnormal immunologic markers is an independent prognostic factor of diffuse large B-cell lymphoma显示文摘Autoimmune diseases (ADs) increase the risk of non-Hodgkin's lymphoma and contribute to poor prognosis of patients. However, the association between immunologic markers and clinical outcome has rarely been investigated. This study aims to analyze the prognostic value of pretreatment immunologic markers in newly diagnosed patients with diffuse large B-cell lymphoma (DLBCL). We retrospectively reviewed the data on 502 patients with DLBCL treated in our institution from January 2013 to March 2018. Survival functions were estimated using Kaplan Meier method and Cox regression model. The 3-year progression free survival (PFS) and overall survival (OS) rates were 70.2% and 80.9%, respectively, and the complete remission (CR) rate was 78.1%. Among the patients, those with multiple (≥3) abnormal immunologic markers had significantly shorter 3-year PFS (52.7% vs. 77.3%, P < 0.001) and OS (68.5% vs. 85.8%, P=0.001) than those without multiple abnormal immunologic markers.Multivariate analysis revealed that the presence of multiple abnormal immunologic markers and the elevated serum levels of lactate dehydrogenase were the independent adverse prognostic factors for PFS (P= 0.008, P < 0.001) and OS (P = 0.003, P < 0.001). Meanwhile, advanced Ann Arbor stage was an independent adverse prognostic factor for PFS (P= 0.001) and age > 60 years for OS (P= 0.014). In conclusion, the immunologic status was closely related to lymphoma progression, and this study provides new insights into the risk stratification of patients with DLBCL. | Yiwen Cao Zhenhua Liu Wen Wu Ying Qian Qin Shi Rong Shen Binshen Ouyang Pengpeng Xu Shu Cheng Jin Ye Yiming Lu Chaofu Wang Chengde Yang Li Wang Weili Zhao | 2019 | Frontiers of Medicine2019，13，1： | 0 |
| 18 | A new species of Exoristobia(Hymenoptera:Encyrtidae)from China显示文摘Exoristobia sinica sp.nov.is described as new to science and a key is provided to the Chinese species based on females. | Guohao Zu Chen Zhang Zening Yang Chengde Li | 2021 | Journal of Forestry Research2021，32，4： | 0 |
| 19 | Indoor Air Pollution and Pulmonary Function in Children显示文摘Pulmonary function in winter time in 1,343 school children aged 10-13 years was measured in four cities locatd in northern and southern part of China.The results showed that FVC,FEV1,PEF,V75,V50and V25 in children living in homes with coal stoves were decreased by 1.5-10.7% compared with children linving in homes with gas or LPG stoves in Chengde and Shanghai.In contrast to this,no significant difference in pulmonary function was found in Shenyang and Wuhan,It suggested that this phenomenon was related to indoor air pollution,and partly related to passive smoking or outdoor air pollution. | SHEN SHANKANG, QIN YUHUI, CAO ZHAOJING, SHANG JIANYING, LIUYUNGQING, YANG XU, DENG YONGQING, HUANG JIANG, FUZHENYING, AND SONG XIANGDONGInstitute of Prevention and Treatment for Occupational Disease, Hubei Institute ofEnvironmental Health Monitoring, Chinese Academy of Preventive Medicine, Beijing Chengde Municipal Sanitation and Anti-epidemic Station, Hebei ShenyangMunicipal Sanitation and Anti-epidemic Station, Liaoning ' WuhanMunicipal Sanitation and Anti-epidemic Station, Hubei ShanghaiMunicipal Sanitation and Anti-epidemic Station, Shanghai, China | 1992 | Biomedical and Environmental Sciences1992，5，2： | 0 |
| 20 | A continuous net-like eutectic structure enhances the corrosion resistance of Mg alloys显示文摘Mg alloys degrade rather rapidly in a physiological environment,although they have good biocompatibility and favorable mechanical properties.In this study,Ti was introduced into AZ61 alloy fabricated by selective laser melting,aiming to improve the corrosion resistance.Results indicated that Ti promoted the formation of Al-enriched eutecticαphase and reduced the formation ofβ-Mg17Al12 phase.With Ti content reaching to 0.5 wt.%,the Al-enriched eutecticαphase constructed a continuous net-like structure along the grain boundaries,which could act as a barrier to prevent the Mg matrix from corrosion progression.On the other hand,the Al-enriched eutecticαphase was less cathodic thanβ-Mg17Al12 phase in AZ61,thus alleviating the corrosion progress due to the decreased potential difference.As a consequence,the degradation rate dramatically decreased from 0.74 to 0.24 mg·cm-2·d-1.Meanwhile,the compressive strength and microhardness were increased by 59.4%and 15.6%,respectively.Moreover,the Ti-contained AZ61 alloy exhibited improved cytocompatibility.It was suggested that Ti-contained AZ61 alloy was a promising material for bone implants application. | Cijun Shuai Wenjing Yang Youwen Yang Chengde Gao Chongxian He Hao Pan | 2019 | International Journal of Bioprinting2019，5，2： | 0 |
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