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| 1 | Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro显示文摘Gastrin and cyclooxygenase-2(COX-2) playimportant roles in the carcinogenesis and progression ofgastric cancer.However,it remains unknown whether the combination of cholecystokinin-2(CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer.Here,we demonstrated that the combination of AG-041R(a CCK-2 receptor antagonist) plus NS-398(a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition,apoptosis induction,down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells.These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.(C)2008 Elsevier Ireland Ltd.All rights reserved. | Sun, W. H. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 30 |
| 2 | Extending the CONSORT Statement to moxibustion显示文摘The STandards for Reporting Interventions in Clinical Trials Of Moxibustion (STRICTOM), in the form of a checklist and descriptions of checklist items, were designed to improve reporting of moxibustion trials, and thereby facilitating their interpretation and replication. The STRICTOM checklist included 7 items and 16 sub-items. These set out reporting guidelines for the moxibustion rationale, details of moxibustion, treatment regimen, other components of treatment, treatment provider background, control and comparator interventions, and precaution measures. In addition, there were descriptions of each item and examples of good reporting. It is intended that the STRICTOM can be used in conjunction with the main CONSORT Statement, extensions for nonpharmacologic treatment and pragmatic trials, and thereby raise the quality of reporting of clinical trials of moxibustion. Further comments will be solicited from the experts of the CONSORT Group, the STRICTA Group, acupuncture and moxibustion societies, and clinical trial authors for optimizing the STRICTOM. | Chung-wah Cheng Shu-fei Fu Qing-hui Zhou Tai-xiang Wu Hong-cai Shang Xu-dong Tang Zhi-shun Liu Jia Liu Zhi-xiu Lin Lixing Lao Ai-ping Lü Bo-li Zhang Bao-yan Liu Zhao-xiang Bian | 2013 | Journal of Integrative Medicine2013，11，1： | 27 |
| 3 | 南京葫芦洞石笋δ^(13)C对冰期气候的复杂响应与诊断显示文摘文中重建了南京葫芦洞内距今75~10ka期间7支石笋δ13C的时间变化序列,δ13C曲线在重叠时段均具有一致性波动形式.在最后一个冰期/间冰期旋回,δ13C值变化幅度达6‰,反映了C3/C4植被类型变化对δ13C的主控作用.然而,在末次冰期格陵兰冰心记录的DO暖事件时(千年尺度),δ13C与指示降水变化的δ18O呈反相关,主要反映了快速渗水条件下洞穴岩溶水对土壤CO2溶解量的降低.据同期生长石笋δ13C和δ18O对比分析,石笋碳同位素动力分馏程度与生长速率有关.进一步研究发现,本区末次冰消期植被类型变化滞后于降水变化约700年. | 孔兴功 汪永进 吴江滢 Cheng Hai L R Edwards Wang Xianfeng | 2005 | 中国科学(D辑)2005，35，11： | 24 |
| 4 | Over-expression of heat shock protein 27 attenuates doxorubicin-induced cardiac dysfunction in mice显示文摘 | Liu,L Zhang,X Qian,B Min,XY Gao,X Li,CF Cheng,YL Huang,J | 2007 | 南京医科大学学报(自然科学版)2007，27，11： | 15 |
| 5 | 具有极性反转的乳头状肾肿瘤:形态学、免疫组化和分子学研究显示文摘作者评估了特殊类型乳头状肾肿瘤的临床病理和染色体特征,并将其与1型和2型乳头状肾细胞癌进行比较。18例中,9例男性,9例女性;年龄范围46~80岁(平均64岁,中位年龄66岁);肿瘤直径0.6~3 cm(平均1.63 cm,中位直径1.4 cm);其中14例WHO/ISUP 2级,4例WHO/ISUP 1级,肿瘤分期均为pT1期。这类肿瘤具有细小纤维血管轴心的分支状乳头,被覆立方/柱状细胞,胞质颗粒状嗜酸性,管腔边缘光滑,核规则且多位于细胞顶端,偶尔核仁明显或不明显。5例形成小管状结构,9例有明显的胞质空泡,10例具有假包膜。18例肿瘤均无砂粒体、坏死、核分裂象和细胞内含铁血黄素沉积。相比之下,1型乳头状肾细胞癌具有纤细的乳头状结构,被覆单层细胞,胞质稀少,细胞核通常位于乳头状结构基底部呈单层排列,而2型乳头状肾细胞癌具有较宽的乳头状结构,表面被覆细胞呈假复层排列,胞质嗜酸性,核无规则分布。1型和2型乳头状肾细胞癌可见砂粒体、泡沫样巨噬细胞以及细胞内含铁血黄素沉积。免疫组化结果显示,18例肿瘤中CK(AE1/AE3)、EMA、MUC1、CD10、GATA3和L1CAM均阳性。 | 魏建国(摘译) 方三高(审校) Al-Obaidy K I Eble J N Cheng L | 2019 | 临床与实验病理学杂志2019，35，8： | 15 |
| 6 | Simulation of rainfall-runoff and watershed convergence process in the upper reaches of Heihe River Basin,July 2002显示文摘The watershed flow concentration scheme in the distributed hydrology-soil- vegetation model (DHSVM) is coupled with the mesoscale atmospheric model MM5 version 3.5, in which the Oregen States University land surface model (OSULSM) was involved. The flood event which happened in July 2002 in the upper reaches of Heihe river basin is simulated and the surface flow convergence process is shown with this coupled model. It has been concluded that times water head reaches each place of the basin are different. Water amount at each point is split-flow proportionally as the drops in elevation between it and neighbor points. Large part of the water amount pass away in greater slope direction and small part pass away in smaller slope one.Adding of the slope convergence makes the atmospheric model redistributes the surface water laterally. | GAO Yanhong L(U) Shihua CHENG Guodong | 2004 | Science China Earth Sciences2004，47，z1： | 13 |
| 7 | RESEARCH ON THE EVALUATION METHOD OF FRICTION AND LUBRICATION IN DEEP DRAWING显示文摘The deformation characteristic of bland in deep drawing is discussed. It is pointed out that the friction and lubrication conditions in for drawing are different from that in mechanical motion or machine work or other plastic process. The common test methods in laboratories are analyzed. It shows that though all those test methods can test the friction coefficient, the probe test method is most suitable for the research of friction and lubrication and the process in deep drawing, for this method is identical with the actual work condition either from the test principle or deformation status of the blank. Last the successful application in the deep drawing simulator newly developed the the probe method are intro- duced in detail. | D. N. He, X. F. Yin, H. Z. Thao, D. L*, X. Y. Ruan, J. L. Cheng and J. Y. Jiang 1) Shanghai Jiao Tong University, National Die & Mold CAD E. R. C, Shanghai 200030, China 2) Shanghai Vopkswagen Automotive Company Ltd., Shanghai 201805, China Manuscript re | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 13 |
| 8 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 9 | Protective effect of early enteral feeding on postburn impairment of liver function and its mechanism in rats显示文摘AIM To study the protective effect of earlyenteral feeding(EEF)on the postburnimpairment of liver function and its mechanism.METHODS Wistar rats with 30% of total bodysurface area(TBSA)full-thickness burn wereemployed.The effects of EEF on the postburnchanges of gastric intramucosal pH,endotoxinlevels in portal vein,water contents of hepatictissue,blood concentrations of tumor necrosisfactor(TNF-α),plasma activities of alanineaminotransferase(ALT)and asparateaminotransferase(AST),as well as the bloodcontents of total(TB)and direct bilirubin(DB),total protein(TP)and albumin(ALB)wereserially determined within 48h postburn.RESULTS EEF could significantly improvegastric mucosal acidosis,reduce portal veinendotoxin level and water content of hepatictissue,as well as plasma concentrations of TNF-α at all timepoints after severe burns(P<0.01);postburn elevation of the plasma activities ofALT,AST and the contents of TB,DB wereeffectively prevented,whereas the plasmaconcentrations of TP and ALB were markedlyincreased 24 h and 48 h posturn in EEF groupcompared with that of the burn without EEFgroup(P<0.01).CONCLUSION EEF has significant beneficialeffects on the improvement of hepatic function in rats after severe burn,and is probably relatedwith an increase in splanchnic blood flow,reduction of the absorption of gut-originendotoxin and the consequent release ofinflammatory mediators. | Zhu L Yang ZC Li A Cheng DC | 2000 | World Journal of Gastroenterology2000，6，1： | 10 |
| 10 | Relationships between use of statins and arterial stiffness in normotensive and hypertensive patients with coronary artery disease显示文摘 | WANG Zhi-guang CHEN Bing-wei L(U) Na-qiang CHENG Yan-mei DANG Ai-min | 2013 | Chinese Medical Journal2013，，16： | 10 |
| 11 | VX-765 reduces neuroinflammation after spinal cord injury in mice显示文摘Inflammation is a major cause of neuronal injury after spinal cord injury. We hypothesized that inhibiting caspase-1 activation may reduce neuroinflammation after spinal cord injury, thus producing a protective effect in the injured spinal cord. A mouse model of T9 contusive spinal cord injury was established using an Infinite Horizon Impactor, and VX-765, a selective inhibitor of caspase-1, was administered for 7 successive days after spinal cord injury. The results showed that:(1) VX-765 inhibited spinal cord injury-induced caspase-1 activation and interleukin-1β and interleukin-18 secretion.(2) After spinal cord injury, an increase in M1 cells mainly came from local microglia rather than infiltrating macrophages.(3) Pro-inflammatory Th1 Th17 cells were predominant in the Th subsets. VX-765 suppressed total macrophage infiltration, M1 macrophages/microglia, Th1 and Th1 Th17 subset differentiation, and cytotoxic T cells activation;increased M2 microglia;and promoted Th2 and Treg differentiation.(4) VX-765 reduced the fibrotic area, promoted white matter myelination, alleviated motor neuron injury, and improved functional recovery. These findings suggest that VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1β/interleukin-18. This may be a potential strategy for treating spinal cord injury. This study was approved by the Animal Care Ethics Committee of Bengbu Medical College(approval No. 2017-037) on February 23, 2017. | Jing Chen Yu-Qing Chen Yu-Jiao Shi Shu-Qin Ding Lin Shen Rui Wang Qi-Yi Wang Cheng Zha Hai Ding Jian-Guo Hu He-Zuo Lü | 2021 | Neural Regeneration Research2021，16，9： | 8 |
| 12 | Reduced gastric acid production in burn shock period and its significance in the prevention and treatment of acute gastric mucosal lesions显示文摘AIM To investigate the changes of gastric acidproduction and its mechanism in shock period ofsevere burn in rats.METHODS A rat model with 30% TBSA full-thickness burn injury was employed and thegastric acid production,together with gastricmucosal blood flow(GMBF)and energy charge(EC)were measured serially within 48hpostburn.RESULTS The gastric acid production in theacute shock period was markedly inhibited aftersevere burn injury.At the 3rd h postburn,thegastric juice volume,total acidity and acidoutput were already significantly decreased(P<0.01),and reached the lowest point,0.63mL/L±0.20mL/L,10.81mmol/L±2.58mmol/L and 2.23mmol/h±0.73mmol/hrespectively,at the 12th h postburn.Althoughrestored to some degree 24 h after thermalinjury,the variables above were stillstatistically lower,compared with those ofcontrol animals at the 48th h postburn.TheGMBF and EC were also significantly reducedafter severe burns,consistent with the trend ofgastric acid production changes.CONCLUSION Gastric acid production,as wellas GMBF and EC was predominantly decreased in the early postburn stage,suggesting that gastricmucosal ischemia and hypoxia with resultantdisturbance in energy metabolism,but notgastric acid proper,might be the decisive factorin the pathogenesis of AGML after thermalinjury,and that the preventive use of anti-aciddrugs during burn shock period wasunreasonable in some respects.Therefore,taking effective measures to improve gastricmucosal blood perfusion as early as possiblepostburn might be more preferable for the AGMLprevention and treatment. | Zhu L Yang ZC Li A Cheng DC | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 13 | Early experiences on living donor liver transplantation in China: multicenter report显示文摘Background Because of the lack of brain death laws in China, the proportion of cadaveric organ donation is low. Many patients with end-stage liver disease die waiting for a suitable donor. Living donor liver transplantation (LDLT) would reduce the current discrepancy between the number of patients on the transplant waiting list and the number of available organ donors. We describe the early experience of LDLT in the mainland of China based on data from five liver transplant centers. Methods Between January 2001 and October 2003, 45 patients with end-stage liver disease received LDLT at five centers in China. The indication and timing, surgical techniques and complications, nonsurgical issues including rejection, infection, and advantages of LDLT in the series were reviewed. Actuarial patient and graft survival rates were calculated by using the Kaplan-Meier product-limit estimate. Statistical analysis was completed by using SPSS 10.0. Results All LDLT recipients were cirrhotic patients, except for one man with fulminant hepatic failure. Among the 45 cases of LDLT, 35 (77.8%) were performed in one center (the First Affiliated Hospital of Nanjing Medical University). The overall 1 and 3 year survival rate of the recipients was 93.1% and 92.0%, respectively. Of the 45 LDLT donors, there were 3 cases of biliary leakage, 2 subphrenic collections, 1 fat liquefaction around the incision and 1 biliary peritonitis after T tube removal. All donors recovered completely. Conclusions LDLT provides an excellent approach to addressing the problem of donor shortage in China even though the operation is complicated, uncompromising and difficult with respect to the safety of the donors and receptors. Despite early technical hurdles having been overcome, perfection of technique is still necessarily. At present, LDLT is a good choice for the patients with irreversible liver disease. | WANG Xue-hao YAN Lü-nan ZHANG Feng LI Xiang-cheng ZHU Ji-ye PENG Zhi-hai LIU Jin-hui LI Guo-qiang CHENG Feng SUN Bei-cheng GE Wen-gang | 2006 | Chinese Medical Journal2006，，12： | 7 |
| 14 | The relationship of Imp2 and DR3 genes with susceptibility to type Ⅰ diabetes mellitus in south China Han population显示文摘AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and DR3-negativegroups.The frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and controls.At the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 years.RESULTS The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P<0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P<0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P<0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P<0.05)and Imp2.R/Hhigher(53% vs 28%,P<0.05)than that incontrols,and there was no significant differenceamong groups with different onset age ofdiabetics.In DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P<0.05)and Imp2-R/H higher(47% vs 13%,P<0.05)than that incontrols.In DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P<0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two groups.CONCLUSION DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of diabeteS.The Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible genotype.These were not affectedby DR3 gene.Imp-2 genotypes were not relatedwith the onset age of diabetics. | Ding HL Cheng H Fu ZZ Deng QL Yan L Yan T | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 15 | Archaeological records of Dadiwan in the past 60 ka and the origin of millet agriculture显示文摘This paper reports the recent excavation of Unit Dadiwan06 at the Dadiwan site in Qin’an County, Gansu.A 65 ka chronological framework is established for Dadiwan06 on the basis of absolute dating (AMS 14C and OSL), stratigraphy, climate change events and archaeology.Artifact distributions reveal patterns of human behavioral variation and adaptation over the past 60 ka, from primitive hunting and gathering to advanced hunting and gathering, to primitive Neolithic agriculture, and finally to advanced Neolithic agriculture. | ZHANG DongJu CHEN FaHu BETTINGER R L BARTON L JI DuXue MORGAN C WANG Hui CHENG XiaoZhong DONG GuangHui GUILDERSON T P ZHAO Hui | 2010 | Chinese Science Bulletin2010，55，16： | 6 |
| 16 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 17 | Physiological and molecular responses to cold stress in rapeseed(Brassica napus L.)显示文摘Low temperature is one of the most important abiotic factors inhibiting growth, productivity, and distribution of rapeseed(Brassica napus L.). Therefore, it is important to identify and cultivate cold-tolerant germplasm. The objective of this study was to figure out the mechanism of chilling(4 and 2°C) and freezing(–2 and –4°C) stresses along with a control(22°C) in B. napus cultivars(1801 and C20) under controlled environment(growth chamber). The experiment was arranged in a complete randomized design with three replications. Our results exhibited that under chilling and freezing stresses, the increment of proline accumulation, soluble sugar and protein contents, and antioxidant enzyme activity were enhanced more in 1801 cultivar compared with C20 cultivar. At –2 and –4°C, the seedlings of C20 cultivar died completely compared with 1801 cultivar. Hydrogen peroxide(H2 O2) and malondialdehyde contents(MDA) increased in both cultivars, but when the temperature was decreased up to –2 and –4°C, the MDA and H2 O2 contents continuously dropped in 1801 cultivar. Moreover, we found that leaf abscisic acid(ABA) was enhanced in 1801 cultivar under chilling and freezing stresses. Additionally, the transcriptional regulations of cold-tolerant genes(COLD1, CBF4, COR6.6, COR15, and COR25) were also determined using real-time quantitative PCR(RT-q PCR). RT-q PCR showed that higher expression of these genes were found in 1801 as compared to C20 under cold stress(chilling and freezing stresses). Therefore, it is concluded from this experiment that 1801 cultivar has a higher ability to respond to cold stress(chilling and freezing stresses) by maintaining hormonal, antioxidative, and osmotic activity along with gene transcription process than C20. The result of this study will provide a solid foundation for understanding physiological and molecular mechanisms of cold stress signaling in rapeseed(B. napus). | YAN Lei Tariq Shah CHENG Yong Lü Yan ZHANG Xue-kun ZOU Xi-ling | 2019 | Journal of Integrative Agriculture2019，18，12： | 6 |
| 18 | High-resolution stalagmite δ13C record of soil processes from southwestern China during the early MIS 3显示文摘Knowledge of the evolution of pedogenic processes in the carbonate area is important to understand the dynamics of rock desertification.A precisely-dated stalagmite δ13C record between 61.3 and 50.5 ka BP from southwestern China,potentially related to soil biogenic CO2 production,shifts within a narrow range between -9‰ and -7‰,and exhibits a prominent cycle of 350-470 a,independent of the Asian monsoon changes.This indicates that a threshold effect might control the amplitude of calcite δ13C variability,likely associated with the vertical soil loss in the carbonate area.The periodic δ13C changes reflect that the loss/recovery of soil cover can operate on centennial scale.Thus,the rock desertification in southwestern China might at least initiate 60 ka ago and should be of natural origin. | LIU DianBing WANG YongJin CHENG Hai EDWARDS R L | 2013 | Chinese Science Bulletin2013，58，7： | 5 |
| 19 | Surgical treatment for primary angle closure-glaucoma: a Meta analysis显示文摘AIM:To evaluate the efficacy and safety of trabeculectomy,phacotrabeculectomy plus intraocular lens implantation(phacotrab+IOL group) and phacoemulsification with IOL(phaco+IOL) in primary angle-closure glaucoma(PACG).METHODS: It was a systematic review and meta-analysis,randomized controlled trials(RCT) and clinical controlled trials(CCT) were collected through electronic searches of the Cochrane Library,PubMed,EMbase,Wanfang Database online,Chinese journal Full-text Database,Chinese Scientific Journals Full-text Database (from the date of building the database to October 2010) We also checked the bibliographies of retrieved articles.All the related data that matched our standards were abstracted.The quality of included trials was evaluated according to the Dutch Cochrane Centre.RevMan 5.0 software was used for Meta-analysis.RESULTS: A total of 5 RCT and 11 CCT involving 1495 eyes were included.The results of meta-analysis showed that phacotrab+IOL group was superior than trabeculectomy(trab group) (MD -3.93,95%CI [-7.31,-0.54]) which was also superior than phaco+IOL group(MD 0.52,95%CI [0.10,0.95]) in decreasing Intraocular Pressure(IOP).Phacotrab group(MD -1.45,95%CI [-1.68,-1.22])and phaco group (MD-1.12,95%CI [-1.87,-0.37])are both deeper than trab group in the anterior chamber depth.In increasing the coefficient of outflow facility of aqueous humor(C values) there was no statistical difference in the three groups.And there was no statistical difference between phacotrab groups and phaco groups in visual acuity but phacotrab group was superior than phaco group (MD 1.07,95%CI [0.73,1.40])in the use of IOP-lowering drugs.There was no statistical difference among three groups.CONCLUSION: Current evidence suggests that phacotrab+ IOL group was superior than trab group which was also superior than phaco+IOL group in decreasing IOP.Phacotrab group and phaco group are both deeper than trab group in the anterior chamber depth.Phacotrab group was superior than phaco group in the use of IOP-lowering drugs. | Bo-Lin Deng, Jing Tian | 2011 | International Journal of Ophthalmology(English edition)2011，4，3： | 5 |
| 20 | Analysis of Powdery Mildew Resistance in Wild Melon MLO Mutants显示文摘Wild species have a potential value in crop breeding. Explore MLO gene which related with powdery mildew natural resistance is very important for improving the quality of melon. Resistance to powdery mildew was examined in cultivar and wild species by leaf inoculation. The wild germplasms showed resistance to powdery mildew Race1. Cloning and sequence analysis of the Cm MLO2 gene identified an 85 bp difference between the wild and cultivated species. The Cm MLO2 gene was expressed in the wild germplasm after fluorescence-labeled Agrobacterium-mediated transformation. A positive transgenic plant showed successful invasion by powdery mildew Race1. These results suggested that the wild species might have failed to encode the MLO protein, thereby resulting in the MLO-negative regulation of powdery mildew, which in turn resulted in the broad-spectrum resistance of the wild species to powdery mildew. | CHENG Hong KONG Weiping Lü Junfen LI Jiping | 2015 | Horticultural Plant Journal2015，1，3： | 5 |
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