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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Prevention of oxidative injury by flavonoids from stems and leaves of Scutellaria baicalensis Georgi in PC12 cells.显示文摘 | Shang YZ Qin BW Cheng JJ Miao H | 2006 | 中国生物学文摘2006，20，10： | 9 |
| 3 | Effet of Maotai liguor in inducing metallothioneins and on hepatic stellate cells显示文摘 | Cheng ML Wu J Wang HQ Xue LM Tan YZ Liu P Li CX Huang NH Yao YM Ren LZ Ye L Li L Jia ML | 2001 | Shijie Huaren Xiaohua Zazhi2001，9，12： | 2 |
| 4 | Dynamic X-ray radiography using a carbon nanotube field emission X-ray source显示文摘 | Cheng Y Zhang J Lee YZ | | 0，，： | 1 |
| 5 | Risk Factors of Post-Traumatic Stress Disorder (PTSD) after Wenchuan Earthquake: a case control study 显示文摘 | Cheng YZ Wang F Wen J | 2014 | PLoS One2014，9，96： | 1 |
| 6 | An ecological study on dynamics of toxic Microcystis blooms in a eutrophic park pond, Wuhan, China | Cheng, K Zhao, YJ Xu, M Yin, J Xiong, Q Zhou, JC Wang, YZ Zhang, W Wang, JW Liu, ZY Wang, FR | 2002 | Progress in Natural Science:Materials International2002，12，1： | 1 |
| 7 | Early changes in morphology and intraocular pressure by size of clear corneal incision显示文摘 | Cheng B Liu Yi Liu Yz | | 0，，06： | 1 |
| 8 | Molecular mecha- nisms responsible for microglia - derived protection of Sprague - Dawley rat brain cells during in vitro ischemia 显示文摘 | Lu YZ Lin CH Cheng FC | 2005 | Neurosci Lett2005，373，： | 1 |
| 9 | Transactivation of proto- oncogene c-Myc by hepatitis B virus transactivator MHBst 167显示文摘 | Lun YZ Cheng J Chi Q | 2014 | Oncol Lett2014，8，2： | 1 |
| 10 | Protection of ischemic brain cells is dependent on astrocyte-derived growth factors and their receptors显示文摘 | Lin CH Cheng FC Lu YZ | 2006 | Exp Neurol2006，201，1： | 1 |
| 11 | Simultaneous separation and determination of active components in Cordyceps sinensis and Cordyceps militaris by LC/ESI- MS 显示文摘 | Huang LF Liang YZ Guo FQ Zhou ZF Cheng BM | 2003 | J Pharm Biomed Anal2003，33，： | 1 |
| 12 | Genetic diversity in mandarin landraces and wild mandarins from China based on nuclear and chloroplast simple sequence repeat markers显示文摘 | Li YZ Cheng YJ Yi HL | 2006 | Journal of Horticultural Science and Biotechnology2006，81，3： | 1 |
| 13 | Effects of amelioration of total flavonoids from stems and leaves of Scutellaria baicalensis Georgi on cognitive deficits, neuronal damage and free radicals disorder induced by cerebral ischemia in rats 显示文摘 | Shang YZ Miao H Cheng JJ etal | 2006 | Bio Pharm Bull2006，29，4： | 1 |
| 14 | Phylogenetic analysis of mandarin landraces, wild mandarins, and related species in China using nuclear LEAFY second Intron and plastid trnL-tmF sequence显示文摘 | Li YZ Cheng YJ Tao NG | 2007 | Journal of the American Soci- ety for Horticultural Science2007，132，6： | 1 |
| 15 | Flexible and accurate implementation of a binocular structured light system显示文摘 | Yang RQ Cheng S Chen YZ | | 0，，： | 1 |
| 16 | Molecular mechanisms responsible for microglia-derived protection of Sprague-Dawley rat brain cells during in vitro ischemia显示文摘 | Lu YZ Lin CH Cheng FC | 2005 | Neurosci Lett2005，373，2： | 1 |
| 17 | To observe the clinical results of accidence of an Array refractive multifocal intraocular lens after phacoemulcification显示文摘 | Lin ZD Feng B Liu YZ Cheng B Zhou YP | 2001 | Rec Adv Ophthalmol2001，21，1： | 1 |
| 18 | Protection of ischemic brain cells is dependent on astrocyte-derived growth factors and their receptors 显示文摘 | Lin CH Cheng FC Lu YZ | 2006 | Exp Neorol2006，201，1： | 1 |
| 19 | The inhibitory effect of altered collagen II peptide on HLA-DRB1-restricted T-cell activation显示文摘 | Cheng YZ Zhou Q Li ZG | 2005 | Scand J Immunol2005，61，： | 1 |
| 20 | Distribution of ferroportin1 protein in different regions of developing rat brain显示文摘 | Jiang DH Ke Y Cheng YZ | 2002 | Dev Neurosci2002，24，23： | 1 |
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