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862篇 您的检索式：作者名="Cheng W B"

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	题名	作者	年代	出处	被引量
1	Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system显示文摘允许的技术内长的基因的特定的规定为基因功能的学习是珍贵的并且在治疗学有大潜力。我们创造了在 CRISPR 上系统,由核酸酶死者 Cas9 (dCas9 ) 蛋白质组成的二部件的 transcriptional 使活跃之物与互补顺序与 transcriptional 激活域和单个指南 RNA (sgRNAs ) 熔化了到基因倡导者。我们证明在 CRISPR 上能高效地以一种悦耳的方式在人和老鼠房间激活外长的记者基因。另外,我们证明在 vivo 的柔韧的记者基因激活能被把系统部件注入老鼠接合子完成。而且,我们证明在 CRISPR 上能激活内长的 IL1RN, SOX2,和 OCT4 基因。最有效的基因激活被对近似倡导者有约束力的 3-4 sgRNAs 的簇完成,建议他们在基因正式就职的 synergistic 行动。显著地,当指向多重基因的 sgRNAs 同时被介绍进房间时,柔韧的多路的内长的基因激活被完成。染色体宽的表示介绍表明了系统的高特性。	Albert W Cheng Haoyi Wang Hui Yang Linyu Shi Yarden Katz Thorold W Theunissen Sudharshan Rangarajan Chikdu S Shivalila Daniel B Dadon Rudolf Jaenisch	2013	Cell Research2013，23，10：	65
2	Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘	Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste	2008	Lancet Neurology2008，，5：	4
3	The flavonoid baicalin protects against cerebrovascular dysfunction brain inflammation in experimental heatstroke显示文摘	Chang C P Huang W T Cheng B C	2007	Neuroparmacology2007，52，：	1
4	A study in Htro on differ- entiation of bone marrow mesenchymal stem cells into endometrial epi- thelial ceils in mice显示文摘	Zhang W B Cheng M J Huang Y T	2012	Eur J Obstet Gynecol Reprod Binl2012，160，2：	1
5	Melt blowing of ionic liquid-based cellulose solutions显示文摘	Song J Lu F Cheng B W	2014	Fibers and Polymers2014，15，2：	1
6	Erectile function restoration after repair of resected cavernous nerves by adipose - derived stem cells combined with autologous vein graft in rats 显示文摘	Ying C Hu W Cheng B	2014	Cell Mel Neurebio12014，34，3：	1
7	Scrap tyres pyrollized in molten salts显示文摘	Lawson J W Cheng B	1976	Chemical Engineering News1976，54，21：	1
8	General axisymmetricactive earth pressure by method of characteristics-theory and numerical formulation显示文摘	CHENG Y M HU Y Y WEI W B	2007	International Journal of Geomechanics2007，7，1：	1
9	Stretch-induced programmed myocyte cell death显示文摘	Cheng W Li B Kajstura J	1995	J Clin Invest1995，96，：	1
10	Feedback stabilization of linear systems with distributed delays in state and control variable显示文摘	Zheng F Cheng M Gao W B	1994	IEEE Trans Automatic Control1994，39，3：	1
11	Roles of substrate microorganism and urease activities Ⅰ: wastewater purification in a constructed wetland system 显示文摘	Liang W Wu Z B Cheng S P	2003	Ecological Engineer2003，21，：	1
12	Experiment and simulation analysis on heat load of heavy-duty vehicle diesel engine 显示文摘	Wang Z W Huang R H Cheng X B	2007	SAE Paper2007，，1：	1
13	Desorption behaviors of BDE-28 and BDE-47 from natural soils with different organic carbon contents 显示文摘	Liu W X Cheng F F Li W B	2012	Environmental Pollution2012，163，：	1
14	Imaging and analyzing the elasticity of vascular smooth muscle cells by atomic force acoustic micro- scope 显示文摘	Zhang B Cheng Q Chen M Yao W G Oian M L Hu B	2012	Ultrasound in Medicine and Biology2012，38，8：	1
15	Flotation behavior and mechanism of rutile with nonyl hydroxamic acid 显示文摘	Wang J Cheng H - W Zhao H - B	2014	Rare Metals2014，，：	1
16	Roles of substrate microorganisms and urease activities in wastewater purification in a constructed wetland system显示文摘	Liang W Wu Z B Cheng S P	2003	Ecological Engineering2003，21，23：	1
17	Investigation of catalytic glycolysis of PET by differential scanning calorimetry显示文摘	KAO C Y CHENG W H WAN B Z	2000	Thermochimica Acta2000，292，12：	1
18	mieroRNA modulation of circadian-clock period and entrainment显示文摘	Cheng H Y Papp J W Varlamova O Dziema H Russell B Cur- fman J P	2007	Neuron2007，54，：	1
19	Catalytic reactions involving C1 feedstocks: new high-activity Zn(Ⅱ)-based catalysts for the alternating copolymerization of carbon dioxide and epoxides显示文摘	CHENG M LOBKOVSKY E B COATES G W	1998	J Am Chem Soc1998，120，11：	1
20	Feedback stabilization of linear systems with distributed delays in state and control variables显示文摘	Zheng F Cheng M W Gao B	1994	IEEE Trans Automatic Control1994，39，：	1

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