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| 1 | 洋葱伯克霍尔德菌对29种抗生素的耐药性分析显示文摘目的 了解洋葱伯克霍尔德菌的耐药特征。方法 用微量稀释法测定洋葱伯克霍尔德菌对 2 9种抗生素的MIC值。结果 2 9种抗生素敏感性测试结果显示 β-内酰胺酶抗生素中青霉素类抗生素哌拉西林、哌拉西林 /他唑巴坦敏感性分别为 82 .2 %和 89.7%;10种头孢类抗生素中的头孢他啶和头孢布烯的敏感性在 85 %左右 ,头孢曲松和头孢克洛为 5 0 %左右 ,其余均 <5 0 %;被测试的两种碳青酶烯类抗生素亚胺培南的敏感性只有7.7%,美罗培南敏感性为 87.2 %;4种氨基糖苷类抗生素敏感率均为 2 .6 %;6种喹诺酮类抗生素除萘啶酸为5 6 .4 %,其他均 <2 5 %;氯霉素的敏感性为 15 .4 %;哌拉西林、哌拉西林 /他唑巴坦、头孢他啶、头孢布烯、美罗培南和甲氧苄啶对洋葱伯克霍尔德菌有较高的活性。结论 洋葱伯克霍尔德菌是一种多重耐药菌 ,体外药敏结果哌拉西林、哌拉西林 /他唑巴坦、头孢他啶、头孢布烯、美罗培南和甲氧苄啶可作为由洋葱伯克霍尔德菌引起感染的治疗药物。 | 罗燕萍 张军民 刘丽 崔岩 杨继勇 Augustine F Cheng | 2002 | 中华医院感染学杂志2002，12，10： | 57 |
| 2 | Comparison between endoscopic sclerotherapy and band ligation for hemostasis of acute variceal bleeding显示文摘AIM:To compare band ligation(BL) with endoscopic sclerotherapy(SCL) in patients admitted to an emergency unit for esophageal variceal rupture. METHODS:A prospective,randomized,single-center study without crossover was conducted.After endoscopic diagnosis of esophageal variceal rupture,patients were randomized into groups for SCL or BL treatment.Sclerotherapy was performed by ethanolamine oleate intravascular injection both above and below the rupture point,with a maximum volume of 20 mL.For BL patients,banding at the rupture point was attempted,followed by ligation of all variceal tissue of the distal esophagus.Primary outcomes for both groups were initial failure of bleeding control(5 d) ,early re-bleeding(5 d to 6 wk),and complications,including mortality.From May 2005 to May 2007,100 patients with variceal bleeding were enrolled in thestudy:50 SCL and 50 BL patients.No differences between groups were observed across gender,age,ChildPugh status,presence of shock at admission,mean hemoglobin levels,and variceal size. RESULTS:No differences were found between groups for bleeding control,early re-bleeding rates,complications,or mortality.After 6 wk,36(80%) SCL and 33(77 %) EBL patients were alive and free of bleeding.A statistically significant association between Child-Pugh status and mortality was found,with 16%mortality in Child A and B patients and 84%mortality in Child C patients(P<0.001) . CONCLUSION:Despite the limited number of patients included,our results suggest that SCL and BL are equally efficient for the control of acute variceal bleeding. | Gustavo Oliveira Luz Fauze Maluf-Filho Sérgio Eiji Matuguma Fábio Yuji Hondo Edson Ide Jeane Martins Melo Spencer Cheng Paulo Sakai | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，5： | 20 |
| 3 | Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication显示文摘Hepatitis B virus(HBV)can cause chronic hepatitis B,which may lead to cirrhosis and liver cancer.Type I interferon(IFN)is an approved drug for the treatment of chronic hepatitis B.However,the fundamental mechanisms of antiviral action by type I IFN and the downstream signaling pathway are unclear.TRIM25 is an IFN-stimulated gene(ISG)that has an important role in RIG-I ubiquitination and activation.Whether TRIM25 is induced in liver cells by type I IFN to mediate anti-HBV function remains unclear.Here we report that interleukin-27(IL-27)has a critical role in IFN-induced TRIM25 upregulation.TRIM25 induction requires both STAT1 and STAT3.In TRIM25 knockout HepG2 cells,type I IFN production was consistently attenuated and HBV replication was increased,whereas overexpression of TRIM25 in HepG2 cells resulted in elevated IFN production and reduced HBV replication.More interestingly,we found that TRIM25 expression was downregulated in HBV patients and the addition of serum samples from HBV patients could inhibit TRIM25 expression in HepG2 cells,suggesting that HBV might have involved a mechanism to inhibit antiviral ISG expression and induce IFN resistance.Collectively,our results demonstrate that type I IFN-induced TRIM25 is an important factor in inhibiting HBV replication,and the IFN-IL-27-TRIM25 axis may represent a new target for treating HBV infection. | Guangyun Tan Qingfei Xiao Hongxiao Song Feng Ma Fengchao Xu Di Peng Na Li Xiaosong Wang Junqi Niu Pujun Gao F Xiao-Feng Qin Genhong Cheng | 2018 | Cellular & Molecular Immunology2018，15，3： | 13 |
| 4 | GURTIN VARIATIONAL PRINCIPLE AND FINITE ELEMENT SIMULATION FOR DYNAMICAL PROBLEMS OF FLUID-SATURATED POROUS MEDIA显示文摘Based on the theory of porous media,a general Gurtin variational principle for theinitial boundary value problem of dynamical response of fluid-saturated elastic porous media isdeveloped by assuming infinitesimal deformation and incompressible constituents of the solid andfluid phase.The finite element formulation based on this variational principle is also derived.Asthe functional of the variational principle is a spatial integral of the convolution formulation,thegeneral finite element discretization in space results in symmetrical differential-integral equationsin the time domain.In some situations,the differential-integral equations can be reduced to sym-metrical differential equations and,as a numerical example,it is employed to analyze the reflectionof one-dimensional longitudinal wave in a fluid-saturated porous solid.The numerical results canprovide further understanding of the wave propagation in porous media. | Yang Xiao Cheng Changjun Department o,f Mechanics, Shanghai Institute of Applied Mathematics and Mechanics,Shanghai University,Shanghai 200436,China) | 2003 | Acta Mechanica Solida Sinica2003，16，1： | 10 |
| 5 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 6 | Thermal and Transmission Properties of UV Nonlinear Optical Material——ZnCd(SCN)_4 Crystal显示文摘Zinc cadmium thiocyanate(ZCTC), ZnCd(SCN) 4, has been discovered as a UV second order nonlinear optical coordination crystal. Its thermal and transmission properties are reported. The thermal decomposition is characterized by using the X ray powder diffraction (XRPD) and infrared (IR) spectroscopy at room temperature. The absorptions of intrinsic ions and ZCTC in a solution state are discussed as well as transmission properties of the ZCTC crystal. An effective method of reducing the surface reflection loss of ZCTC crystal is introduced. | NING H X, XU D, WANG X Q, CHENG X F, YANG Z H (Institute of Cryst. Mater. and State Key Lab. of Cryst. Mater., Shandong University, Jinan 250100, CHN) | 2002 | Semiconductor Photonics and Technology2002，8，1： | 4 |
| 7 | Non-suicidal self-injury in Shanghai inner bound middle school students显示文摘Background Non-suicidal self-injury (NSSI) behaviour is very common among adolescents. Its prevalence and behavioural characteristics may vary according to regional and cultural differences. Investigation of NSSI locations and diagnosis of adolescents with NSSI are relatively lacking in China. Aims The study objective was to determine the prevalence and features of NSSI among middle school students in Shanghai. Methods The participants were from grade 6 to 8 selected from three junior schools in Jing’an District. Consenting students completed the Ottawa Self-Injury Inventory to determine the prevalence and characteristics of NSSI. Those who indicated NSSI within the past month were administered the Mini-International Neuropsychiatric Interview for Children and Adolescents to assess for emotional disorders. Result The result shows 510 participants (21.7%;mean age 13.51 (0.97) years old;56.7% female) reported at least one instance of NSSI during the previous 12 months. NSSI was significantly more common in girls than boys (24.9% vs 18.5%;χ^2=14.03, p=0.00). Commonly reported reasons for NSSI were for internal and external emotion regulation (87.9%, 82.3%) and social influence (57.8%). Anxiety disorders were the most common (28.9%) disorder associated with NSSI. Conclusion The rate of NSSI of middle school students in Shanghai inner bound is similar to those reported in North American and European youth. It is essential that school mental health professionals are aware of how to manage NSSI within the school setting. | Fang Zhang Paula F Cloutier Hongmei Yang Wenjing Liu Wenhong Cheng Zeping Xiao | 2019 | General Psychiatry2019，32，4： | 3 |
| 8 | Magnitude of modulation of gene expression in aneuploid maize depends on the extent of genomic imbalance显示文摘Aneuploidy has profound effects on an organism,typically more so than polyploidy,and the basis of this contrast is not fully understood.A dosage series of the maize long arm of chromosome 1(1L)was used to compa re relative global gene expression in diffe rent types and degrees of aneuploidy to gain insights into how the magnitude of genomic imbalance as well as hypoploidy affects global gene expression.While previously available methods require a selective examination of specific genes,RNA sequencing provides a whole-genome view of gene expression in aneuploids.Most studies of global aneuploidy effects have concentrated on individual types of aneuploids because multiple dose aneuploidies of the same genomic region are difficult to produce in most model genetic organisms.The genetic toolkit of maize allows the examination of multiple ploidies and 1-4 doses of chromosome arms.Thus,a detailed examination of expression changes both on the varied chromosome arms and elsewhere in the genome is possible,in both hypoploids and hyperploids,compared with euploid controls.Previous studies observed the inverse trans effect,in which genes not varied in DNA dosage were expressed in a negative relationship to the varied chromosomal region.This response was also the major type of changes found globally in this study.Many genes varied in dosage showed proportional expression changes,though some were seen to be partly or fully dosage compensated.It was also found that the effects of aneuploidy were progressive,with more severe aneuploids producing effects of greater magnitude. | Adam F·Johnson Jie Hou Hua Yang Xiaowen Shi Chen Chen Md Soliman Islam Tieming Ji Jianlin Cheng James A·Birchler | 2020 | Journal of Genetics and Genomics2020，47，2： | 3 |
| 9 | 显示文摘 | Cheng H F Lin T F Hu C T | 1993 | J Am Ceram Soc1993，76，4： | 2 |
| 10 | Laser transformation hardening of AISI440C martensitic stainless steel for higher cavitation erosion resistance显示文摘 | Lo K H Cheng F T Man H C | 2003 | Surface and Coating Technology2003，173，： | 2 |
| 11 | A Model for Liquid-Diffusion Catalytically Grown Fibrous Carbon Material显示文摘A mechanism for the catalytically growth of vapor grown fibrous carbon (VGFC) preparing from the floating catalyst method has been proposed, in which liquid diffusion-determined diffusionof carbon atoms through catalyst particles is described mathematically, and the physical andchemical properties of the catalyst particIes during the growth process are taken into account.From the model the growth rate and grown length of VGFC are calculated theoretically whichcoincides with the experimental datal and the necessity of reducing gas such as hydrogen inpreparing VGFC is explained as to reduce Fe3C, which acts as intermediate catalyst shown bythe model. Fe3C formed on the surface of γ-Fe will stop the growth of carbon fiber if they cannot be reduced at once. Additionally, the growth temperature and diameter of VGFC are alsodiscussed in the paper. | Zhang, WG Cheng, HM Su, G Fan, YY Li, F Shen, ZH Zhou, BL | 1999 | Journal of Materials Science & Technology1999，15，1： | 2 |
| 12 | A multi-domain boundary element solution for silencer and muffler performance prediction显示文摘 | Cheng C Y R Seybert A F | 1991 | J Sound and Vibration1991，151，1： | 2 |
| 13 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 14 | Distribution feeder reconfiguration with refined genetic algorithm显示文摘 | Lin M W Cheng F S Tsay M T | 2000 | IEE Proceedings of Generation Transmission and Distribution2000，147，6： | 2 |
| 15 | Tension and compression tests of two polymers under quasi-static and dynamic loading显示文摘 | Chen W Lu F Cheng M | 2002 | Polymer Testing2002，，21： | 1 |
| 16 | Multi-stage vacuum cooling process of cabbage 显示文摘 | Cheng H P Hsueh C F | 2007 | Journal of Food Engineer2007，79，1： | 1 |
| 17 | Combinatorial modification of multiple lignin traits in trees through multigene cotransformation 显示文摘 | Li L Zhou Y Cheng X F | 2003 | Plant Biology2003，100，8： | 1 |
| 18 | NF-κB is activated and ICAM-1 gene expression is upregulated during reoxygenation of human brain endothelial cells显示文摘 | Howard E F Chen Q Cheng C | 1998 | Neurosci Lett1998，248，3： | 1 |
| 19 | Pillared of layered titanate by poly oxocations of Aluminum显示文摘 | Wang T C | 1989 | Inorg Chem1989，28，7： | 1 |
| 20 | Oxidation and defect control of CVD SiC coating on three-dimensional C/SiC composites显示文摘 | Cheng L F Xu Y D Zhang L T | 2002 | Carbon2002，40，： | 1 |
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