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| 1 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 2 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 3 | Distribution feeder reconfiguration with refined genetic algorithm显示文摘 | Lin M W Cheng F S Tsay M T | 2000 | IEE Proceedings of Generation Transmission and Distribution2000，147，6： | 2 |
| 4 | Tension and compression tests of two polymers under quasi-static and dynamic loading显示文摘 | Chen W Lu F Cheng M | 2002 | Polymer Testing2002，，21： | 1 |
| 5 | Northward migration of Helicoverpa armigera and Other motha in early summer observedwith radar in Northern China显示文摘 | Feng H Q Wu K M Cheng D F | 2004 | Journal of Economic Entomology2004，97，6： | 1 |
| 6 | Isolation of new thermophilic aermostable α-amylase显示文摘 | Jin F X Cheng X M Shi Y F | 1990 | J Gen appl Microb1990，36，： | 1 |
| 7 | Radar observations of the autumn migration of the beet armyworm Spodoptera exigua (Lepidoptera: Noctuidae) and other moths in northern China显示文摘 | Feng H Q Wu K M Cheng D F | 2003 | Bull Entomol Res2003，93，2： | 1 |
| 8 | Characteristics, apa tire-forming ability and corrosion resistance of NiTi surface modified by AC anodization 显示文摘 | WONG M H CHENG F T MAN H C | 2007 | Appl Surface Sci2007，253，18： | 1 |
| 9 | The 3-PRS parallel spindle module with the multi-posture vertical and horizontal machining capability显示文摘 | Huang Y M Cheng X Gao F | 2005 | International Journal of Production Research2005，43，3： | 1 |
| 10 | Positional variations in phytic acid and protein content within a panicle of japonica rice显示文摘 | Liu Z H Cheng F M Cheng W D | 2005 | J Cereal Sci2005，41，： | 1 |
| 11 | Effects of temperature, pH, salinity and ammonia on the phagocytic activity and clearance efficiency of giant freshwater prawn Macrobrachium rosenbergii to Lactococcus garvieae 显示文摘 | CHENG W CHEN S M WANG F I | 2003 | Aquaculture2003，219，1： | 1 |
| 12 | Antiviral effect of epigallocatechin gallate on enterovirus 71显示文摘 | Ho H Y Cheng M L Weng S F | | 0，，14： | 1 |
| 13 | Crystal structure of unliganded influen- za B virus haemagglutinin 显示文摘 | Wang Q Cheng F Lu M | 2008 | J Virol2008，82，6： | 1 |
| 14 | Hepatoprotective effect of Phyllanthus in Taiwan on acute liver damage induced by carbon tetrachloride显示文摘 | Lee C Y Peng W H Cheng H Y Chen F N Lai M T | 2006 | The American Journal of Chinese Medicine2006，34，3： | 1 |
| 15 | Study on physical properties and nerve cell affinity of composite films from chitosan and gelatin solutions显示文摘 | CHENG M Y DENG J G YANG F | 2003 | Biomaterials2003，24，： | 1 |
| 16 | Feedback stabilization of linear systems with distributed delays in state and control variable显示文摘 | Zheng F Cheng M Gao W B | 1994 | IEEE Trans Automatic Control1994，39，3： | 1 |
| 17 | Real-time 3-dimensional echocardiography in assessing atrial and ventricular septal defects:an echocardiographic-surgical correlative study显示文摘 | CHENG T O XIE M X WANG X F | 2004 | American Heart J2004，148，： | 1 |
| 18 | Battery performance and photocatalytic activity of mesoporous anatase TiO2 nanospheres/graphene composites by template-free self-assembly 显示文摘 | Li N Liu G Zhen C Li F Zhang L L Cheng H M | 2011 | Advanced Functional Materials2011，21，9： | 1 |
| 19 | Expression patterns of genes involved in sugar metabolism and accumulation during apple fruit development 显示文摘 | LI M FENG F CHENG L | 2012 | PLoS One2012，7，33： | 1 |
| 20 | Biohydrometallurgical iron oxidation and precipitation: Part I-- Effect of pH on process performance显示文摘 | KAKSONEN A H MORRIS C REA S LI J WYLIE J USHER K M G1NIGE M P CHENG K Y HILARIO F du PLESSIS C A | 2014 | Hydrometallurgy2014，，： | 1 |
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