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| 1 | Clinical application of a new device for minimally invasive circumcision显示文摘瞄准:与 phimosis 或过量包皮在不同年龄的男病人的治疗学习一台可处理的割礼设备的临床的效果。方法:在 5 和 95 年的年龄之间的 1200 个病人在在 2005 年 10 月和 2007 年 9 月之间的 2 年的时期用这个过程经历了割礼。这些盒子, 904 有过量包皮, 296 是 phimosis 的盒子。结果:在 96.33% 盒子中,切口愈合了,离开没有使好化妆结果留下疤痕并且生产的内部包皮的最小的数量。没有到系带的设备脱臼或损坏的事件。平均起作用的时间为 phimosis 是为过量包皮,和 3.5 min 的 2.5 min。在穿设备的 7 天期间,对中等浮肿温和与 phimosis 与过量包皮并且在那些的 2.58 % 发生在盒子的 10.08 % 。在系带的浮肿在 1.67% 病人被看见,并且仅仅, 0.67% 有切口的感染。86.25% 病人的一个总数由于阴茎勃起报导了疼痛。在设备的移动以后, 0.58% 案例有在切口附近的最小的流血,并且 2.42% 弯屈裂开。结论:新设备能与 phimosis 和过量包皮被用于病人的一个压到优势的多数。这种技术相对简单表现,并且经历了这个手术的病人有很少的复杂并发症。抗菌素没比用常规方法被割除的那些被要求,病人们报导了更少的疼痛。有这台设备的割礼要求最小的组织操作,并且比用常规技术的割礼更快、安全。 | Yi-Feng Peng Yue Cheng Guo-Yao Wang Suo-Qun Wang Chao Jia Ben-Hai Yang Ru Zhu Shu-Chuan Jian Qing-Wen Li Da-Wei Geng | 2008 | Asian Journal of Andrology2008，10，3： | 105 |
| 2 | Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study显示文摘Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. | Li-Li Ren Ye-Ming Wang Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang | 2020 | Chinese Medical Journal2020，，9： | 99 |
| 3 | Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats显示文摘Objective:Our previous research showed that Naotaifang(a compound traditional Chinese herbal medicine)extract(NTE)has clinically beneficial effects on neurological improvement of patients with acute cerebral ischemia.In this study,we investigated whether NTE protected acute brain injury in rats and whether its effects on ferroptosis could be linked to the dysfunction of glutathione peroxidase 4(GPX4)and iron metabolism.Methods:We established an acute brain injury model of middle cerebral artery occlusion(MCAO)in rats,in which we could observe the accumulation of iron in neurons,as detected by Perl’s staining.Using assay kits,we measured expression levels of ferroptosis biomarkers,such as iron,glutathione(GSH),reactive oxygen species(ROS)and malonaldehyde(MDA);further the expression levels of transferrin receptor1(TFR1),divalent metal transporter 1(DMT1),solute carrier family 7 member 11(SLC7 A11)and GPX4 were determined using immunohistochemical analysis,real-time quantitative polymerase chain reaction and Western blot assays.Results:We found that treatment with NTE reduced the expression levels of TFR1 and DMT1,reduced ROS,MDA and iron accumulation and reduced neurobehavioral scores,relative to untreated MCAO rats.Treatment with NTE increased the expression levels of SLC7 A11,GPX4 and GSH,and the number of Nissl bodies in the MCAO rats.Conclusion:Taken together,our data suggest that acute cerebral ischemia induces neuronal ferroptosis and the effects of treating MCAO rats with NTE involved inhibition of ferroptosis through the TFR1/DMT1 and SCL7 A11/GPX4 pathways. | Bin Lan Jin-wen Ge Shao-wu Cheng Xi-long Zheng Jun Liao Chao He Zheng-qing Rao Guo-zuo Wang | 2020 | Journal of Integrative Medicine2020，18，4： | 37 |
| 4 | Uric acid stimulates endothelin-1 gene expression associated with NADPH oxidase in human aortic smooth muscle cells显示文摘瞄准:最近的试验性、人的研究证明了 hyperuricemia 与高血压和心血管的疾病被联系。endothelin-1 (ET-1 ) 的提高的层次被认为是心血管的疾病的最强大的独立预言者之一。为调查尿导致酸的脉管的疾病是否与 ET-1 有关,在人的大动脉的光滑的肌肉房间(HASMC ) 的尿导致酸的 ET-1 表示被检验。方法:与尿酸,房间增长和 ET-1 表示对待的有教养的 HASMC 被检验。尿导致酸的细胞外的调整信号的家族 ases (英皇家空军之阶级最低之兵) 上的抗氧化剂预告的处理 phosphorylation 被执行阐明在增长和 ET-1 基因表示的氧化还原作用敏感的小径。结果:尿酸被发现增加 HASMC 增长, ET-1 表示和反应的氧种类生产。N-acetylcysteine 和 apo-cynin 的能力(l-[4-hydroxy-3-methoxyphenyl ] ethanone,一个 NADPH oxidase 禁止者) 建议了细胞内部的氧化还原作用小径的参与禁止尿导致酸的 ET-1 分泌物和房间增长。而且, apocynin,和 p47 phox 击倒的禁止的 ET-1 分泌物和房间增长由尿酸导致了的小介入 RNA。由 U0126 的英皇家空军之阶级最低之兵的抑制(1,4-diamino-2,3-dicyano-1,4-bis [2-aminophenylthio ] 丁二烯) 显著地压制的尿导致酸的 ET-1 表示,含有在对尿酸的反应的这条小径。另外,尿酸增加了抄写因素使活跃之物 protein-1 (AP-1 ) 调停的记者活动,以及 ERK phosphorylation。ET-1 基因倡导者的 Mutational 分析证明 AP-1 有约束力的地点是在尿导致酸的 ET-1 基因表示的重要 cis 元素。结论:这是由在 HASMC 的尿酸的 ET-1 规定的第一观察,它含有在脉管的变化的尿酸的重要角色与高血压和脉管的疾病联系了。 | Hung-hsing CHAO Ju-chi LIU Jia-wei LIN Cheng-hsien CHEN Cheng-hsi WU Tzu-hurng CHENG | 2008 | Acta Pharmacologica Sinica2008，29，11： | 31 |
| 5 | Construction, expression and characterization of the engineered antibody against tumor surface antigen, p185^(c-erbB-2)显示文摘The c-erbB-2 proto-oncogene encodes a 185kDa protein p185, which belongs to epidermal growth factorreceptor family. Amplification of this gene has been shown to correlate with poor clinical prognosis forcertain cancer patients. The monoclonal antibody A21 which directed against p185 specifically inhibitsproliferation of tumor cells overexpressing p185, hence allows it to be a candidate for targeted therapy. Inorder to overcome several drawbacks of murine MAb, we cloned its VH and VL genes and constructed thesingle-chain Fv (scFv) through a peptide linker. The recombinant scFvA21 was expressed in Escherichiacoli and purified by the affinity column. Subsequently it was characterized by ELISA, Western blot, cellimmunohistochemistry and FACS. All these assays showed the binding activity to extracellular domain(ECD) of p185. Based on those properties of scFvA21, we further constructed the scFv-Fc fusion moleculewith a homodimer form and the recombinant product was expressed in mammalian cells. In a series ofsubsequent analysis this fusion protein showed identical antigen binding site and activity with the parentantibody. These anti-p185 engineered antibodies have promised to be further modified as a tumor targetingdrugs, with a view of application in the diagnosis and treatment of human breast cancer. | LIAN SHENG CHENG, AI PING LIU, JIA HONG YANG, YAN QIU DONG, LIANG WEI LI, JING WANG, CHAO CHEN WANG, JING LIUSchool of Life Science, University of Science and Technology of China, Hefei 230027, China | 2003 | Cell Research2003，13，1： | 24 |
| 6 | The second natural gas hydrate production test in the South China Sea显示文摘Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to exploit.They are proved to be exploitable by the first NGH production test conducted in the South China Sea in 2017.Based on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the reservoirs.After that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April 2020.During the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate depressurization.As a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 m3.Thus,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production test.Therefore,both the cumulative gas production and the daily gas production were highly improved compared to the first production test.As indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production test.This successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH reservoirs.The industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial production.The second production test serves as an important step from the exploratory production test to experimental production test. | Jian-liang Ye Xu-wen Qin Wen-wei Xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng Wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong Hang Bian | 2020 | China Geology2020，3，2： | 22 |
| 7 | Overexpression of P53 and its risk factors in esophageal cancer in urban areas of Xi′an显示文摘OverexpressionofP53anditsriskfactorsinesophagealcancerinurbanareasofXi′anQIAOGuiBin1,HANChengLong2,JIANGRenChao1,SUNChang?.. | QIAO GuiBin1, HAN ChengLong2, JIANG RenChao1, SUN ChangSheng3, WANG Yan3 and WANG YunJie3 | 1998 | World Journal of Gastroenterology1998，4，1： | 21 |
| 8 | SIMULATION OF FLUID-SOLID INTERACTION ON WATER DITCHING OF AN AIRPLANE BY ALE METHOD显示文摘Ditching is considered as one of the important aspects of safety performances of airplanes.It is related primarily with the fluid-solid interaction,whose studies mainly depend on experiments at the present time.Numerical and analytical methods for fluid-solid interaction by using 3-D full scale airplane's model will reduce the dependence on the expensive model tests.Numerical studies can be used to estimate the safety of ditching and provide a reference for the crashworthiness design.This article proposes a 3-D dynamical structural model after the real shape of an airplane and an Arbitrary Lagrange-Euler (ALE) fluid-field model,to simulate the fluid-solid interactions caused by low speed ditching.The simulation is based on interaction computational methods,within LS-DYNA nonlinear finite-element code.The results of pressure distributions and accelerating time histories of the airplane's subfloor are discussed in the context of the safety of ditching,and the simulation results and the analytical methods are verified. | HUA Cheng FANG Chao CHENG Jin | 2011 | Journal of Hydrodynamics2011，23，5： | 20 |
| 9 | Characterization of drug responses of mini patient-derived xenografts in mice for predicting cancer patient clinical therapeutic response显示文摘Background:Patient-derived organoids and xenografts(PDXs)have emerged as powerful models in functional diag-nostics with high predictive power for anticancer drug response.However,limitations such as engraftment failure and time-consuming for establishing and expanding PDX models followed by testing drug efficacy,and inability to subject to systemic drug administration for ex vivo organoid culture hinder realistic and fast decision-making in selecting the right therapeutics in the clinic.The present study aimed to develop an advanced PDX model,namely MiniPDX,for rapidly testing drug efficacy to strengthen its value in personalized cancer treatment.Methods:We developed a rapid in vivo drug sensitivity assay,OncoVee®MiniPDX,for screening clinically relevant regimens for cancer.In this model,patient-derived tumor cells were arrayed within hollow fiber capsules,implanted subcutaneously into mice and cultured for 7 days.The cellular activity morphology and pharmacokinetics were systematically evaluated.MiniPDX performance(sensitivity,specificity,positive and negative predictive values)was examined using PDX as the reference.Drug responses were examined by tumor cell growth inhibition rate and tumor growth inhibition rate in PDX models and MiniPDX assays respectively.The results from MiniPDX were also used to evaluate its predictive power for clinical outcomes.Results:Morphological and histopathological features of tumor cells within the MiniPDX capsules matched those both in PDX models and in original tumors.Drug responses in the PDX tumor graft assays correlated well with those in the corresponding MiniPDX assays using 26 PDX models generated from patients,including 14 gastric cancer,10 lung cancer and 2 pancreatic cancer.The positive predictive value of MiniPDX was 92%,and the negative predictive value was 81%with a sensitivity of 80%and a specificity of 93%.Through expanding to clinical tumor samples,Min-iPDX assay showed potential of wide clinical application.Conclusions:Fast in vivo MiniPDX assay based on capsule implantation was developed-to assess drug responses of both PDX tumor grafts and clinical cancer specimens.The high correlation between drug responses of paired MiniPDX and PDX tumor graft assay,as well as translational data suggest that MiniPDX assay is an advanced tool for personalized cancer treatment. | Feifei Zhang Wenjie Wang Yuan Long Hui Liu Jijun Cheng Lin Guo Rongyu Li Chao Meng Shan Yu Qingchuan Zhao Shun Lu Lili Wang Haitao Wang Danyi Wen | 2018 | Cancer Communications2018，38，1： | 20 |
| 10 | Infection with novel coronavirus(SARS-CoV-2)causes pneumonia in Rhesus macaques显示文摘The 2019 novel coronavirus(SARS-CoV-2)outbreak is a major challenge for public health.SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases,with a mortality rate of^6.4%worldwide(based on World Health Organization daily situation report).However,the dynamics of viral infection,replication and shedding are poorly understood.Here,we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2.After intratracheal inoculation,the first peak of viral RNA was observed in oropharyngeal swabs one day post infection(1 d.p.i.),mainly from the input of the inoculation,while the second peak occurred at 5 d.p.i.,which reflected on-site replication in the respiratory tract.Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals,characterized by hyperemia and edema,and infiltration of monocytes and lymphocytes in alveoli.We also identified SARS-CoV-2 RNA in respiratory tract tissues,including trachea,bronchus and lung;and viruses were also re-isolated from oropharyngeal swabs,bronchus and lung,respectively.Furthermore,we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2.The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. | Chao Shan Yan-Feng Yao Xing-Lou Yang Yi-Wu Zhou Ge Gao Yun Peng Lian Yang Xue Hu Jin Xiong Ren-Di Jiang Hua-Jun Zhang Xiao-Xiao Gao Cheng Peng Juan Min Ying Chen Hao-Rui Si Jia Wu Peng Zhou Yan-Yi Wang Hong-Ping Wei Wei Pang Zheng-Fei Hu Long-Bao Lv Yong-Tang Zheng Zheng-Li Shi Zhi-Ming Yuan | 2020 | Cell Research2020，30，8： | 19 |
| 11 | Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown. | Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 12 | Expression of VEGF_(121)in gastric carcinoma MGC803 cell line显示文摘INTRODUCTIONVascular endothelial growth factor(VEGF)whichis also known as vascular permeability factor(VPF)is a heparin-binding,dimeric polypeptide growthfactor and a potent mitogen for endothelial cells.VEGF can stimulate the endothelial cell growth andenhance the motility through its two knownreceptors flt-1 and KDR.Acting through thesereceptors,VEGF may stimulate angiogenesis | Xue Jun Tian Jian Wu Lin Meng Zhi Wei Dang Cheng Chao Shou Beijing Institute for Cancer Research,Oncology School of Beijing Medical University,Beijing 100034,China Institute of Cancer Research,Chinese Academy of Medical Sciences,Beijing 100021,China | 2000 | World Journal of Gastroenterology2000，6，2： | 17 |
| 13 | Transmutation of ancient settlements and environmental changes between 6000-2000 aBP in the Chaohu Lake Basin, East China显示文摘Based on the temporal-spatial distribution features of ancient settlement sites from the middle and late Neolithic Age to the Han dynasty in the Chaohu Lake Basin of Anhui Province,East China,using the methods of GIS combined with the reconstructed paleoenvironment by the records of lake sediment since Holocene,the transmutation of ancient settlements with response to environmental changes in this area has been discussed.Studies show that the main feature of transmutation of ancient settlements from the middle and late Neolithic Age to the Han Dynasty was that the distribution of settlements in this area changed from high altitudes to low ones and kept approaching the Chaohu Lake with the passage of time.These could be the response to the climate change from warm-moist to a relatively warm-dry condition during the middle Holocene,leading to the lake level fluctuations.The large area of exposed land provided enough space for human activities.These indicate that the above changes in geomorphologic evolution and hydrology influenced by climate conditions affected the transmutation of ancient settlements greatly.The distribution pattern of settlement sites was that the number of sites in the west was more than in the east.This pattern may be related to the geomorphologic conditions such as frequent channel shifting of the Yangtze River as well as flood disasters during the Holocene optimum.Therefore,climate change was the inducement of the transmutation of ancient settlements in the Chaohu Lake Basin,which exerted great influence on the distribution,expansion and development of the ancient settlements. | WU Li WANG Xinyuan ZHOU Kunshu MO Duowen ZHU Cheng GAO Chao ZHANG Guangsheng LI Lan LIU Li HAN Weiguang | 2010 | Journal of Geographical Sciences2010，20，5： | 16 |
| 14 | The Deep-Time Digital Earth program:data-driven discovery in geosciences显示文摘Current barriers hindering data-driven discoveries in deep-time Earth(DE)include:substantial volumes of DE data are not digitized;many DE databases do not adhere to FAIR(findable,accessible,interoperable and reusable)principles;we lack a systematic knowledge graph for DE;existing DE databases are geographically heterogeneous;a significant fraction of DE data is not in open-access formats;tailored tools are needed.These challenges motivate the Deep-Time Digital Earth(DDE)program initiated by the International Union of Geological Sciences and developed in cooperation with national geological surveys,professional associations,academic institutions and scientists around the world.DDE’s mission is to build on previous research to develop a systematic DE knowledge graph,a FAIR data infrastructure that links existing databases and makes dark data visible,and tailored tools for DE data,which are universally accessible.DDE aims to harmonize DE data,share global geoscience knowledge and facilitate data-driven discovery in the understanding of Earth’s evolution. | Chengshan Wang Robert MHazen Qiuming Cheng Michael HStephenson Chenghu Zhou Peter Fox Shu-zhong Shen Roland Oberhansli Zengqian Hou Xiaogang Ma Zhiqiang Feng Junxuan Fan Chao Ma Xiumian Hu Bin Luo Juanle Wang Craig M.Schiffries | 2021 | National Science Review2021，8，9： | 14 |
| 15 | Characteristics of PM_(2.5) pollution in Beijing after the improvement of air quality显示文摘Following the implementation of the strictest clean air policies to date in Beijing,the physicochemical characteristics and sources of PM_(2.5) have changed over the past few years.To improve pollution reduction policies and subsequent air quality further,it is necessary to explore the changes in PM_(2.5) over time.In this study,over one year(2017-2018)field study based on filter sampling(TH-150C;Wuhan Tianhong,China)was conducted in Fengtai District,Beijing,revealed that the annual average PM_(2.5) concentration(64.8±43.1μg/m^3)was significantly lower than in previous years and the highest PM_(2.5) concentration occurred in spring(84.4±59.9μg/m^3).Secondary nitrate was the largest source and accounted for 25.7%of the measured PM_(2.5).Vehicular emission,the second largest source(17.6%),deserves more attention when considering the increase in the number of motor vehicles and its contribution to gaseous pollutants.In addition,the contribution from coal combustion to PM_(2.5) decreased significantly.During weekends,the contribution from EC and NO3−increased whereas the contributions from SO4^2−,OM,and trace elements decreased,compared with weekdays.During the period of residential heating,PM_(2.5) mass decreased by 23.1%,compared with non-heating period,while the contributions from coal combustion and vehicular emission,and related species increased.With the aggravation of pollution,the contribution of vehicular emission and secondary sulfate increased and then decreased,while the contribution of NO3−and secondary nitrate continued to increase,and accounted for 34.0%and 57.5%of the PM_(2.5) during the heavily polluted days,respectively. | Xiaojuan Huang Guiqian Tang Junke Zhang Baoxian Liu Chao Liu Jin Zhang Leilei Cong Mengtian Cheng Guangxuan Yan Wenkang Gao Yinghong Wang Yuesi Wang | 2021 | Journal of Environmental Sciences2021，33，2： | 14 |
| 16 | Satellite SAR interferometric observations of displacements associated with urban subsidence in Suzhou, Eastern China显示文摘SAR interferometry (InSAR) has a high potential for surface displacement mapping in the range from millimeter to meter. In this paper the potential of ERS-1/2 SAR interferometry for mapping subtle land subsidence has been investigated. A time series of ERS-1/2 SAR data from February 1993 to February 2000 is collected from measurements taken in Suzhou city, Jiangsu Province, China, eight ERS-1/2 SAR images are used to create seven interferograms, and three differential interferograms are produced using the three-pass method, which clearly show the spatial extent of land subsidence. The deformation maps are validated by leveling surveys, the correlation coefficient and standard deviation between them are 0.943 and 0.1706 respectively. Based on seven benchmarks, the subsidence rates are estimated, the overall trends are in close agreement with InSAR results. The results of study show that for the mapping of land subsidence in urban environments InSAR has a strong potential due to its cost-saving, high resolution and accuracy. | WANG Chao, ZHANG Hong, LIU Zhi, CHENG Suozhong and LU Guonian(1. LARSIS, Institute of Remote Sensing Applications, Chinese Academy of Sciences, Beijing 100101, China 2. Department of Geography, Nanjing Normal University, Nanjing 210097, China) | 2002 | Progress in Natural Science:Materials International2002，12，10： | 13 |
| 17 | Effect of introduced phthalate-degrading bacteria on the diversity of indigenous bacterial communities during di-(2-ethylhexyl) phthalate (DEHP) degradation in a soil microcosm显示文摘 | Chao WL Cheng CY | 2007 | 中国生物学文摘2007，21，6： | 13 |
| 18 | Inhibitory effects of polyphyllins I and VII on human cisplatin-resistant NSCLC via p53 upregulation and CIP2A/AKT/mTOR signaling axis inhibition显示文摘Cancerous inhibitor of protein phosphatase 2A(CIP2A) is a human oncoprotein that is overexpressed in multiple kinds of cancers including non-small cell lung cancer(NSCLC). CIP2A plays an ’oncogenic nexus’ to participate in the tumorigenesis and chemoresistance in several cancer types. AKT and m TORC1 overactivation are detected in NSCLC and many other cancers. Previous studies found that the CIP2A/AKT/m TOR pathway controls cell growth, apoptosis, autophagy process. Polyphyllin I(PPI) and polyphyllin VII(PPVII) are natural components extracted from Paris polyphylla that display anti-cancer properties. In the present study, we investigated whether PPI and PPVII can be used in the cisplatin(DDP)-resistant human NSCLC cell line A549/DDP. Results demonstrated that PPI and PPVII treatment significantly suppressed A549/DDP cell proliferation, migration, invasion and EMT, induced apoptosis and autophagy. Further examination of the mechanism revealed that the PPI and PPVII significantly upregulated the p53, induced caspase-dependent apoptosis and suppressed the CIP2A/AKT/m TOR pathway. The activation of autophagy was mediated through PPI and PPVII induced inhibition of m TOR. We propose that PPI and PPVII might be developed as candidate drugs for DDP-resistant NSCLC. | FENG Fei-Fei CHENG Peng SUN Chao WANG Hui WANG Wei | 2019 | Chinese Journal of Natural Medicines2019，17，10： | 13 |
| 19 | New prospecting progress using information and big data of coal and oil exploration holes on sandstone-type uranium deposit in North China显示文摘1.Objective A series of Mesozoic-Cenozoic continental sedimentary basins exist in North China,coexisting with coal,oil/gas,and salt resources.Many previous drilling projects have been conducted within these basins to explore coal,petroleum,and mineral resources,however,these data have not been integrated due to different industries owners.In order to efficiently explore the large-sized,easily extracted,and environmentally friendly,sandstone-type uranium deposits,previous coal and oil exploration drilling-hole data are systematically collected, processed,and analyzed to improve the sandstone-type uranium prospecting exploitation.At the same time,we also discussed the uranium source,ore-forming process and model for the sandstone-type uranium deposits. | Ruo-shi Jin Pei-sen Miao Xian-zhang Sima Reng-An Yu Yin-hang Cheng Chao Tang Tian-fu Zhang Cong Ao Xue-ming Teng | 2018 | China Geology2018，1，1： | 12 |
| 20 | A theoretical prediction of chemical zonation in early oceans(>520 Ma)显示文摘Early oceans(>520 Ma) were characterized by widespread water-column anoxia, stratification, and limited oxidant availability, which are comparable to the chemical characteristics of modern marine sedimentary pore-waters in productive continental margins. Based on this similarity and our current understanding of the formation mechanism of early Earth ocean chemistry, we propose an idealized chemical zonation model for early oceans that includes the following redox zones(from shallow nearshore to deep offshore regions): oxic, nitrogenous(NO3?-NO2?-enriched), manganous-ferruginous(Mn2+ or Fe2+-enriched), sulfidic(H2S-enriched), methanic(CH4-enriched), and ferruginous(Fe2+-enriched). These zones were dynamically maintained by a combination of processes including surface-water oxygenation by atmospheric free oxygen, nitrate reduction beneath the chemocline, nearshore manganese-iron reduction, sulfate reduction, methanogenesis, and hydrothermal Fe2+ inputs from the deep ocean. Our modified 'euxinic wedge' model expands on previous versions of this model, providing a more complete theoretical framework for the chemical zonation of early Earth oceans that helps to explain observations of unusual Mo-S-C isotope patterns. This model may provide a useful foundation for future studies of ocean chemistry evolution and elemental biogeochemical cycles in early Earth history. | LI Chao CHENG Meng Thomas J.ALGEO XIE ShuCheng | 2015 | Science China Earth Sciences2015，58，11： | 11 |
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