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| 1 | MAP Kinases in Immune Responses显示文摘MAP kinases are evolutionarily conserved signaling regulators from budding yeast to mammals and play essential roles in both innate and adaptive immune responses. There are three main families of MAPKs in mammals. Each of them has its own activators, inactivators, substrates and scaffolds, which altogether form a fine signaling network in response to different extracellular or intracellular stimulation. In this review, we summarize recent advances in understanding of the regulation of MAP kinases and the roles of MAP kinases in innate and adaptive immune responses. | YongliangZhang ChenDong | 2005 | Cellular & Molecular Immunology2005，2，1： | 19 |
| 2 | Dissolved organic matter removal using magnetic anion exchange resin treatment on biological effluent of textile dyeing wastewater显示文摘This study investigated the removal of dissolved organic matter(DOM) from real dyeing bio-treatment effluents(DBEs) with the use of a novel magnetic anion exchange resin(NDMP).DOMs in two typical DBEs were fractionized using DAX-8/XAD-4 resin and ultrafiltration membranes. The hydrophilic fractions and the low molecular weight(MW)(<3 kDa) DOM fractions constituted a major portion(>50%) of DOMs for the two effluents. The hydrophilic and low MW fractions of both effluents were the greatest contributors of specific UV254absorbance(SUVA254),and the SUVA254 of DOM fractions decreased with hydrophobicity and MW. Two DBEs exhibited acute and chronic biotoxicities. Both acute and chronic toxicities of DOM fractions increased linearly with the increase of SUVA254 value. Kinetics of dissolved organic carbon(DOC) removal via NDMP treatment was performed by comparing it with that of particle active carbon(PAC). Results indicated that the removal of DOC from DBEs via NDMP was 60%,whereas DOC removals by PAC were lower than 15%. Acidic organics could be significantly removed with the use of NDMP. DOM with large MW in DBE could be removed significantly by using the same means. Removal efficiency of NDMP for DOM decreased with the decrease of MW. Compared with PAC,NDMP could significantly reduce the acute and chronic bio-toxicities of DBEs. NaCl/NaOH mixture regenerants,with selected concentrations of 10% NaCl(m/m)/1%NaOH(m/m),could improve desorption efficiency. | Jun Fan Haibo Li Chendong Shuang Wentao Li Aimin Li | 2014 | Journal of Environmental Sciences2014，26，8： | 14 |
| 3 | Biological effect of velvet antler polypeptides on neural stem cells from embryonic rat brain显示文摘Background Velvet antler polypeptides (VAPs), which are derived from the antler velvets, have been reported to maintain survival and promote growth and differentiation of neural cells and, especially the development of neural tissues This study was designed to explore the influence of VAPs on neural stem cells in vitro derived from embryonic rat brain Methods Neural stem cells derived from E12 14 rat brain were isolated, cultured, and expanded for 7 days until neural stem cell aggregations and neurospheres were generated The neurospheres were cultured under the condition of different concentration of VAPs followed by immunocytochemistry to detect the differentiation of neural stem cells Results VAPs could remarkablely promote differentiation of neural stem cells and most neural stem cells were induced to differentiate towards the direction of neurons under certain concentration of VAPs Conclusion Neural stem cells can be successfully induced into neurons by VAPs in vitro , which could provide a basis for regeneration of the nervous | LULai-jin CHENLei MENGXiao-ting YANGFan ZHANGZhi-xin CHENDong | 2005 | Chinese Medical Journal2005，，1： | 14 |
| 4 | Genome-wide association analysis identified molecular markers associated with important tea flavor-related metabolites显示文摘The characteristic secondary metabolites in tea(theanine,caffeine,and catechins)are important factors contributing to unique tea flavors.However,there has been relatively little research on molecular markers related to these metabolites.Thus,we conducted a genome-wide association analysis of the levels of these tea flavor-related metabolites in three seasons.The theanine,caffeine,and catechin levels in Population 1 comprising 191 tea plant germplasms were examined,which revealed that their heritability exceeded 0.5 in the analyzed seasons,with the following rank order(highest to lowest heritabilities):(+)-catechin>(−)-gallocatechin gallate>caffeine=(−)-epicatechin>(−)-epigallocatechin-3-gallate>theanine>(−)-epigallocatechin>(−)-epicatechin-3-gallate>catechin gallate>(+)-gallocatechin.The SNPs detected by amplified-fragment SNP and methylation sequencing divided Population 1 into three groups and seven subgroups.An association analysis yielded 307 SNP markers related to theanine,caffeine,and catechins that were common to all three seasons.Some of the markers were pleiotropic.The functional annotation of 180 key genes at the SNP loci revealed that FLS,UGT,MYB,and WD40 domain-containing proteins,as well as ATP-binding cassette transporters,may be important for catechin synthesis.KEGG and GO analyses indicated that these genes are associated with metabolic pathways and secondary metabolite biosynthesis.Moreover,in Population 2(98 tea plant germplasm resources),30 candidate SNPs were verified,including 17 SNPs that were significantly or extremely significantly associated with specific metabolite levels.These results will provide a foundation for future research on important flavor-related metabolites and may help accelerate the breeding of new tea varieties. | Kaixing Fang Zhiqiang Xia Hongjian Li Xiaohui Jiang Dandan Qin Qiushuang Wang Qing Wang Chendong Pan Bo Li Hualing Wu | 2021 | Horticulture Research2021，8，1： | 10 |
| 5 | Generator Unit Fault Diagnosis Using the Frequency Slice Wavelet Transform Time-frequency Analysis Method显示文摘为了提取有效的故障特征,提出了基于频率切片小波变换时频分解的故障特征分离提取方法。先对信号进行频率切片小波变换获取其时频分布,然后根据信号的能量分布特点选择时频区域,再以较高的时频分辨率对选择的时频区域进一步细化分析,以突出隐含在信号中的时频特征,在此基础上分割出含有故障特征时频区域,再通过滤波和逆变换重构分离出有效的故障特征。仿真实验和工程应用表明,这种方法可从噪声信号中分离出有效的特征分量,在发电机组故障特征提取时取得了较好的效果。 | DUAN Chendong GAO Qiang XU Xianfeng | 2013 | 中国电机工程学报2013，33，32： | 9 |
| 6 | Protective effect of melatonin against liver injury in mice induced by Bacillus Calmette-Guerin plus lipopolysaccharide显示文摘AIM: To investigate the effects and mechanisms of melatonin on immunological liver injury in mice.METHODS: A model of liver injury was induced by tail vein injecton of Bad#us Calmet~ Guenn (BCG) and lipopolysaccharide(LPS) in mice. Kupffer cells and hepatocytes were isolated and cultured according to a modified two-step collagenase perfusion technique. Levels of alanine aminotransferase(ALT), aspartate aminotransferase (AST) and nitric oxide(NO), content of malondiadehyde (MDA), activity of superoxide dismutase (SOD), were measured by biochemical methods.Tumor necrosis factor-α (TNF-α) activity was determined by RIA. Interleukin (IL)-1 activity was measured by thymocyte proliferation bioassay. Hepatic tissue sections were stained with hematoxylin and eosin and examined under a lightmicroscope.RESULTS: Immunological liver injury induced by BCG+LPS was successfully duplicated. Serum transaminase (ALT,AST) activities were significantly decreased by melatonin(0.25, 1.0, 4.0 mg/kg bm). Meanwhile, MDA content was decreased and SOD in liver homogenates was upregulated.Furthermore, pro-inflammatory mediators (TNF-α, IL-1, NO)in serum and liver homogenates were significantly reduced by melatonin. Histological examination demonstrated that melatonin could attenuate the area and extent of necrosis,reduce the immigration of inflammatory cells. In in vitro experiment, TNF-α was inhibited at the concentrations of 10^-8-10^-6 mol/L of melatonin, while IL-1 production of Kupffer cells induced by LPS (5 t^g/mL) was decreased only at the concentration of 10^-6 mol/L of melatonin, but no effect on NO production was observed. Immunological liver injury model in vitro was established by incubating hepatocytes with BCG- and LPS-induced Kupffer cells. Activities of ALT,TNF-α, IL-1, and MDA in supernatant were significantly increased. Melatonin had little effect on the level of ALT,but reduced the content of TNF-α and MDA at concentrations of 10^-7-10^-5 mol/L and decreased the content of IL-1 at concentrations of 10^-6-10^-5 mol/L.CONCLUSION: Melatonin could significantly protect liver injury in mice, which was related to free radical scavenging,increased SOD activity and pro-inflammatory mediators. | HuaWang WeiWei Yu-XianShen ChenDong Ling-LingZhang Ni-PingWang LiYue Shu-YunXu | 2004 | World Journal of Gastroenterology2004，10，18： | 7 |
| 7 | Evidence of China's sea boundary in the South China Sea显示文摘According to a series of important historical maps,i.e.,the Location Map of the South China Sea Islands,the Nansha Islands,Zhongsha Islands,Xisha Islands,Yongxing Island and Shidao Island,and Taiping Island(archived by the Territorial Administration Division of the Ministry of Interior of Republic of China in 1946),and the Administration District Map of the Republic of China published in 1948,the dashed line surrounding the South China Sea Islands represents China's sea boundary in the South China Sea at that time.It was both connected with,and an extension of,the land boundary of China.At that time the dashed line was used to represent the waters boundaries while the solid line was used to represent the land boundary—a universal method used in maps that was then recognized internationally.The above observation provides historical and scientific evidence of China's sea boundary in the South China Sea that is useful for the international maritime delimitation over the South China Sea area. | WANG Ying GE Chendong ZOU Xinqing | 2017 | Acta Oceanologica Sinica2017，36，4： | 6 |
| 8 | Spatial and temporal variations of sedimented organic matter in Xiaohai Lagoon,Hainan Island显示文摘The characteristics of grain-size,total organic carbon(TOC) and total nitrogen(TN) contents,TOC/TN ratios,stable carbon isotope(δ13C) and 210 Pb dating were measured in six sediment cores from the Xiaohai Lagoon.The results show distinct spatial and temporal variations in sedimentation patterns.The sediments are dominated by clayey silt,sandy silt and by silty sand in the southern,middle lagoon and the northern lagoon,respectively.TOC and TN contents decline from south to north.Sedimentation rates,determined by 210 Pb dating,tend to decrease from south to middle.However,the determination of sedimentation rate in the north is difficult.These spatial variations are related to the variations in sediment sources and hydrodynamic conditions in the Xiaohai Lagoon.The variations of organic matter signatures can be divided into two stages in the cores from the southern and middle lagoon.Before 1988,the organic matter signatures are relatively stable.The contribution of terrestrial organic carbon sources varies between 60% and 85%.After 1988,the organic matter signatures demonstrate significant variations.TOC and TN contents increase rapidly,TOC/TN ratios decrease,δ13C values shift to higher and the contribution of terrestrial organic carbon sources decreases to 40%-50%.The contributions of phytoplankton organic matter have increased in the sediment since 1988.Increasing aquaculture activities have had a significant impact on organic matter signatures since 1988.The sedimentation rates have increased rapidly in the southern and middle lagoon since 1988 due to the anthropogenic activities which include aquaculture,mining and deforestation.These activities have caused eutrophication and increased siltation in the southern and middle lagoon. | LIU Xingjian GE Chendong | 2012 | Acta Oceanologica Sinica2012，31，3： | 3 |
| 9 | Optimizing mechanical and magnetic properties of AlCoCrFeNi high-entropy alloy via FCC to BCC phase transformation显示文摘FCC,BCC and B2 phases,the most common phases in high-entropy alloys(HEAs),are widely investigated to tailor their mechanical and magnetic performances.The detailed investigation of FCC to BCC/B2 phase transformation of Al Co Cr Fe Ni HEA in this paper reveals its evolution and structure-properties relations in terms of both temperature and holding duration.With increasing heat treatment temperature and duration,such transition will progress simultaneously at both the dendric core(DC)region and interdendric(ID)region and the volume of phase transformation from FCC to BCC phases is greater than FCC to B2 phases,resulting in increased yield strength and saturation magnetization.The obvious phase transition of the Al Co Cr Fe Ni HEA at 1200℃can enhance its yield strength and saturation magnetization as a sacrifice of its fracture strain.However,an excellent combination of mechanical-magnetic properties was achieved when heat-treated at 1100℃for 50 h by optimizing both the transformation and the size of B2 phases.Our present study could pave ways to design the HEAs or other alloys with an optimum combination of mechanical and magnetic properties for application-oriented viewpoints. | Chendong Zhao Jinshan Li Yudong Liu Xiao Ma Yujie Jin William Yi Wang Hongchao Kou Jun Wang | 2021 | Journal of Materials Science & Technology2021，，27： | 3 |
| 10 | Preparation of a permanent magnetic hypercrosslinked resin and assessment of its ability to remove organic micropollutants from drinking water显示文摘基于新奇永久磁性的 hypercrosslinked 树脂, W150 在喝水为器官的 micropollutants 的移动被建议的一个快速、有效的方法。W150 被暂停和 crosslinking 以后反应准备并且发现了拥有 1149.7 m 的一个高特定的表面区域 < 啜 class= “ a-plus-plus ” > 2 敢漠 ? 桴 ? 潢吗? | Wei WANG Yan MA Qing ZHOU Chendong SHUANG Mancheng ZHANG Aimin LI | 2015 | Frontiers of Environmental Science & Engineering2015，9，1： | 3 |
| 11 | Tailoring mechanical and magnetic properties of AlCoCrFeNi high-entropy alloy via phase transformation显示文摘Phase constitutions,either changed by alloying or by phase transformation,are the key factors to determine the magnetic and mechanical performances of high-entropy alloys(HEAs).Using the AlCoCrFeNi HEA as a candidate alloy,this paper demonstrates the effect of phase transformation on both the mechanical and magnetic properties in the multi-phase system.With increasing heat treatment temperature,the sigma(σ)and face-centered-cubic(FCC)phases disappeared at 1000℃and 1200℃,respectively.Such volume fraction changes ofσ,FCC and body-centered-cubic(BCC)phases have divergent effects on mechanical and magnetic properties.The excellent strength-ductility combination will be achieved as the disappearance ofσphase and formation of FCC phase.As for the magnetic properties,the volume fraction of BCC phase plays a major role in determining its saturation magnetization.When the volume fraction change of BCC phase is not evident,the higher volume fraction of FCC phase will influence its magnetization at 2 T.Our present work might provide insights into analyzing the evolution of both mechanical and magnetic properties of HEAs caused by complex phase transformation. | Chendong Zhao Jinshan Li Yudong Liu William Yi Wang Hongchao Kou Eric Beaugnon Jun Wang | 2021 | Journal of Materials Science & Technology2021，，14： | 2 |
| 12 | Diurnal variations of carbon dioxide,methane,and nitrous oxide fluxes from invasive Spartina alterniflora dominated coastal wetland in northern Jiangsu Province显示文摘The invasions of the alien species such as Spartina alterniflora along the northern Jiangsu coastlines have posed a threat to biodiversity and the ecosystem function.Yet,limited attention has been given to their potential influence on greenhouse gas(GHG) emissions,including the diurnal variations of GHG fluxes that are fundamental in estimating the carbon and nitrogen budget.In this study,we examined the diurnal variation in fluxes of carbon dioxide(CO_2),methane(CH_4),and nitrous oxide(N2O) from a S.alterniflora intertidal flat in June,October,and December of 2013 and April of 2014 representing the summer,autumn,winter,and spring seasons,respectively.We found that the average CH_4 fluxes on the diurnal scale were positive during the growing season while negative otherwise.The tidal flat of S.alterniflora acted as a source of CH_4 in summer(June) and a combination of source and sink in other seasons.We observed higher diurnal variations in the CO_2 and N_2O fluxes during the growing season(1 536.5 mg CO_2 m^(–2) h^(–1) and 25.6 μg N_2O m^(–2) h^(–1)) compared with those measured in the non-growing season(379.1 mg CO_2 m^(–2) h^(–1) and 16.5 μg N_2O m^(–2) h^(–1)).The mean fluxes of CH_4 were higher at night than that in the daytime during all the seasons but October.The diurnal variation in the fluxes of CO_2 in June and N_2O in December fluctuated more than that in October and April.However,two peak curves in October and April were observed for the diurnal changes in CO_2 and N_2O fluxes(prominent peaks were found in the morning of October and in the afternoon of April,respectively).The highest diurnal variation in the N_2O fluxes took place at 15:00(86.4 μg N_2O m^(–2) h^(–1)) in June with an unimodal distribution.Water logging in October increased the emission of CO_2(especially at nighttime),yet decreased N_2O and CH_4 emissions to a different degree on the daily scale because of the restrained diffusion rates of the gases.The seasonal and diurnal variations of CH_4 and CO_2 fluxes did not correlate to the air and soil temperatures,whereas the seasonal and diurnal variation of the fluxes of N_2O in June exhibited a significant correlation with air temperature.When N_2O and CH_4 fluxes were converted to CO_2-e equivalents,the emissions of N_2O had a remarkable potential to impact the global warming.The mean daily flux(MF) and total daily flux(TDF) were higher in the growing season,nevertheless,the MF and TDF of CO_2 were higher in October and those of CH_4 and N_2O were higher in June.In spite of the difference in the optimal sampling times throughout the observation period,our results obtained have implications for sampling and scaling strategies in estimating the GHG fluxes in coastal saline wetlands. | XU Xinwanghao FU Guanghe ZOU Xinqing GE Chendong ZHAO Yifei | 2017 | Acta Oceanologica Sinica2017，36，4： | 2 |
| 13 | Preparation of a novel anion exchange group modified hyper-crosslinked resin for the effective adsorption of both tetracycline and humic acid显示文摘与一个阴离子交换组一起修改的新奇的超树脂(MENQ ) 经由四步作为 comonomers 用 divinylbenzene (DVB ) 和甲基 acrylate (麻省) 被准备:暂停聚合, crosslinking 以后, ammonolysis 和完化反应。获得的树脂两个都有一个高特定的表面区域(793.34 m < 啜 class= “ a-plus-plus ” > 2 | Qing ZHOU Mengqiao WANG Aimin LI Chendong SHUANG Mancheng ZHANG Xiaohan LIU Liuyan WU | 2013 | Frontiers of Environmental Science & Engineering2013，7，3： | 2 |
| 14 | Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia显示文摘Hepatic cholesterol accumulation is an important contributor to hypercholesterolemia,which results in atherosclerosis and cardiovascular disease(CVD).ATP-citrate lyase(ACLY)is a key lipogenic enzyme that converts cytosolic citrate derived from tricarboxylic acid cycle(TCA cycle)to acetyl-CoA in the cytoplasm.Therefore,ACLY represents a link between mitochondria oxidative phosphorylation and cytosolic de novo lipogenesis.In this study,we developed the small molecule 326E with an enedioic acid structural moiety as a novel ACLY inhibitor,and its CoA-conjugated form 326E-CoA inhibited ACLY activity with an IC_(50)=5.31±1.2μmol/L in vitro.326E treatment reduced de novo lipogenesis,and increased cholesterol efflux in vitro and in vivo.326E was rapidly absorbed after oral administration,exhibited a higher blood exposure than that of the approved ACLY inhibitor bempedoic acid(BA)used for hypercholesterolemia.Chronic 326E treatment in hamsters and rhesus monkeys resulted in remarkable improvement of hyperlipidemia.Once daily oral administration of 326E for 24 weeks prevented the occurrence of atherosclerosis in ApoE^(-/-)mice to a greater extent than that of BA treatment.Taken together,our data suggest that inhibition of ACLY by 326E represents a promising strategy for the treatment of hypercholesterolemia. | Zhifu Xie Mei Zhang Qian Song Long Cheng Xinwen Zhang Gaolei Song Xinyu Sun Min Gu Chendong Zhou Yangming Zhang Kexin Zhu Jianpeng Yin Xiaoyan Chen Jingya Li Fajun Nan | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 15 | Gear- box fault diagnosis using adaptive redundant lifting scheme 显示文摘 | Jiang Hongkai He Zhengjia Duan Chendong | 2006 | Mechanical Systems and Signal Process- ing2006，20，8： | 1 |
| 16 | Gearbox fault diagnosis using adaptive redundant Lifting Scheme显示文摘 | Jiang Hongkai He Zhengjia Duan Chendong Chen Peng | 2005 | Mechanical Systems and Signal Processing2005，，8： | 1 |
| 17 | Quatemized mag- netic microspheres for the efficient removal of reactive dyes 显示文摘 | Shuang Chendong Li Penghui Li Aimin | 2012 | Water Research2012，46，14： | 1 |
| 18 | Fault diagnosis using adaptive redundant lifting scheme显示文摘 | Jiang Hongkal He Zhengjia Duan Chendong | 2006 | Mechanical Systems and Signal Processing2006，20，8： | 1 |
| 19 | A sliding window feature extraction method for rotating machinery based on the lifting scheme显示文摘 | Duan Chendong He Zhengjia Jiang Hongkal | 2007 | Journal of Sound and Vibration2007，299，45： | 1 |
| 20 | Combustion reaction mechanism of four typical Chinese biomass by TG and DTG显示文摘 | Pei‐ShengLi QinWang QiaoXu WanYu Ya‐NanYue ZheLiang Xing‐ChenDong SongHu | 2012 | Asia‐Pac J Chem Eng2012，，： | 1 |
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