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| 1 | Review on supermolecules as chemical drugs显示文摘Supramolecular medicinal chemistry field has been a quite rapidly developing,increasingly active and newly rising interdiscipline which is the new expansion of supramolecular chemistry in pharmaceu-tical sciences,and is gradually becoming a relatively independent scientific area. Supramolecular drugs could be defined as medicinal supermolecules formed by two or more molecules through non-covalent bonds. So far a lot of supermolecules as chemical drugs have been widely used in clinics. Supermolecules as chemical drugs,i.e. supramolecular chemical drugs or supramolecular drugs,which might have the excellences of lower cost,shorter period,higher potential as clinical drugs for their successful research and development,may possess higher bioavailability,better biocompatibility and drug-targeting,fewer multidrug-resistances,lower toxicity,less adverse effect,and better curative effects as well as safety,and therefore exhibit wide potential application. These overwhelming advan-tages have drawn enormous special attention. This paper gives the definition of supramolecular drugs,proposes the concept of supramolecular chemical drugs,and systematically reviews the recent ad-vances in the research and development of supermolecules,including organic and inorganic complex ones as chemical drugs in the area of antitumor,anti-inflammatory,analgesic,antimalarial,antibacterial,antifungal,antivirus,anti-epileptic,cardiovascular agents and magnetic resonance imaging agents and so on. The perspectives of the foreseeable future and potential application of supramolecules as chemical drugs are also presented. | ZHOU ChengHe GAN LinLing ZHANG YiYi ZHANG FeiFei WANG GuangZhou JIN Lei GENG RongXia | 2009 | Science China Chemistry2009，52，4： | 17 |
| 2 | Remarks on the Regularity to 3-D Ideal Magnetohydrodynamic Equations显示文摘In this paper we are interested in the sufficient conditions which guarantee the regularity of solutions of 3-D ideal magnetohydrodynamic equations in the arbitrary time interval [0,T]. Five sufficient conditions are given. Our results are motivated by two main ideas: one is to control the accumulation of vorticity alone; the other is to generalize the corresponding geometric conditions of 3-D Euler equations to 3-D ideal magnetohydrodynamic equations. | QuanSenJIU ChengHE | 2004 | Acta Mathematica Sinica,English Series2004，20，4： | 11 |
| 3 | A series of naphthalimide azoles: Design, synthesis and bioactive evaluation as potential antimicrobial agents显示文摘A series of naphthalimide azoles as potential antibacterial and antifungal agents were conveniently and efficiently synthesized starting from commercially available 6-bromobenzo[de]isochromene-1,3-dione. All the new compounds were characterized by NMR, IR, MS and HRMS spectra. Their antimicrobial activities were evaluated against four Gram-positive bacteria, four Gram-negative bacteria and two fungi using two-fold serial dilution technique. The biological assay indicated that most of the prepared compounds exhibited inhibition to the tested strains. In particular, the triazolium derivatives not only gave higher efficacy than their corresponding precursory azoles, but also demonstrated comparable or even better potency than the reference drugs Chloromycin, Orbifloxacin and Fluconazole. Some factors including structural fragments, pH and ClogP values of the target molecules were also preliminarily discussed. | DAMU Guri L. V. WANG QingPeng ZHANG HuiZhen ZHANG YiYi LV JingSong ZHOU ChengHe | 2013 | Science China Chemistry2013，56，7： | 8 |
| 4 | In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model显示文摘The urokinase-type plasminogen activator(uPA)loaded hollow nanogels(nUK)were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly(ethylene oxide).The resultant formulation is sensitive to diagnostic ultrasound(US)of 2 MHz.Herein,we evaluated the in vivo sonothrombolysis performance of the nUK on acute ischemic stroke rat model which was established by suture embolization of middle cerebral artery(MCA).Via intravenous(i.v.)administration,the experimental data prove a controlled release of the therapeutic protein around the clots under ultrasound stimulation,leading to enhanced thrombolysis efficiency of the nUK,evidenced from smaller infarct volume and better clinical scores when compared to the i.v.dose of free uPA no matter with or without US intervention.Meanwhile,the preservation ability of the nanogels not only prolonged the circulation duration of the protein,but also resulted in the better blood-brain barrier protection of the nUK formulation,showing no increased risk on the hemorrhagic transformation than the controls.This work suggests that the nUK is a safe sonothrombolytic formulation for the treatment of acute ischemic stroke. | Yuming Teng Haiqiang Jin Ding Nan Mengnan Li Chenghe Fan Yuanyuan Liu Pu Lv Wei Cui Yongan Sun Hongjun Hao Xiaozhong Qu Zhenzhong Yang Yining Huang | 2018 | Bioactive Materials2018，3，1： | 7 |
| 5 | Synthesis and biological activities of thio-triazole derivatives as novel potential antibacterial and antifungal agents显示文摘A series of novel thio-triazole derivatives including thiols, thioethers and thiones as well as some corresponding triazolium compounds were conveniently and efficiently synthesized from commercially available halobenzyl halides and thiosemicarbazide. All the new compounds were characterized by 1 H NMR, 13 C NMR, FTIR, MS and HRMS spectra. Their antibacterial and antifungal activities in vitro were evaluated against four Gram-positive bacteria, four Gram-negative bacteria and two fungi by two-fold serial dilution technique. The preliminary bioassay indicated that some prepared triazoles exhibited effective antibacterial and antifungal activities. Especially, 3,4-dichlorobenzyl triazolethione and its triazolium derivatives displayed the most potent activities against all the tested strains. | WANG QingPeng ZHANG JingQing DAMU Guri L.V. WAN Kun ZHANG HuiZhen ZHOU ChengHe | 2012 | Science China Chemistry2012，55，10： | 7 |
| 6 | Design,synthesis,and biological evaluation of novel benzimidazole derivatives and their interaction with calf thymus DNA and synergistic effects with clinical drugs显示文摘A series of new benzimidazole derivatives was synthesized and characterized by IR,1H NMR,13C NMR,MS,and HRMS spectra.All the new compounds were screened for their antimicrobial activities in vitro by a twofold serial dilution technique.The bioactive evaluation showed that 3,5-bis(trifluoromethyl)phenyl benzimidazoles were comparably or even more strongly antibacterial and antifungal than the reference drugs Chloromycin,Norfloxacin,and Fluconazole.The combination of2,4-difluorobenzyl benzimidazole derivative 5l and its hydrochloride 7 respectively with the antibacterials Chloromycin,Norfloxacin,and the antifungal Fluconazole was more sensitive to methicillin-resistant MRSA and Fluconazole-insensitive A.flavus.In addition,the interaction of compound 5l with calf thymus DNA demonstrated that this compound could effectively intercalate into DNA to form a compound 5l-DNA complex that might block DNA replication and thereby exert good antimicrobial activity. | ZHANG HuiZhen LIN JianMei RASHEED Syed ZHOU ChengHe | 2014 | Science China Chemistry2014，57，6： | 5 |
| 7 | The complete mitochondrial genome of the Keeled box turtle Pyxidea mouhotii and phylogenetic analysis of major turtle groups显示文摘The complete mitochondrial genome (16,837 bp) from the Keeled box turtle (Pyxidea mouhotii) was determined. The genome content, gene order, and base composition conformed to the consensus vertebrate type mtDNA. However, a remarkable feature was found in this molecule: a large number of (ATTATATC) n direct tandem repeats followed by (TA) n microsatellite at the 3′ end of the control region (D-loop), which might be useful as molecular markers for studying population genetics and helpful for species identification and conser- vation. Besides, to review phylogenetic relationships among major turtle lineages, maximum-likelihood (ML) and Bayesian (BI) analyses were conducted based on concatenated sequences of 13 protein-coding genes from 16 taxa. The resultant ML and BI analyses showed homological topologies, which only differed on the exact placement of Platysternon. Nevertheless, the results strongly supported that 1) Pyxidea mouhotii and Cuora aurocapitata formed a monophyletic clade, whereas Cyclemys atripons was not closer to the Pyxidea-Cuora than to Chinemys reevesii, suggesting that Cyclemys and the Cuora group (containing Pyxidea) may have originated from two ancestors; 2) the Geoemydidae with Testudinidae was a sister group rather than with the Emydidae. | Li Zhang Liuwang Nie Chenghe Cao Ying Zhang | 2008 | Journal of Genetics and Genomics2008，35，1： | 3 |
| 8 | Study of the Toxicity of 1-Bromo-3-Chloro-5,5-Dimethylhydantoin to Zebrafish显示文摘Objective 1-Bromo-3-chloro-5,5-dimethylhydantoin (BCDMH) is a solid oxidizing biocide for water disinfection.The objective of this study was to investigate the toxic effect of BCDMH on zebrafish.Methods The developmental toxicity of BCDMH on zebrafish embryos and the dose-effect relationship was determined.The effect of BCDMH exposure on histopathology and tissue antioxidant activity of adult zebrafish were observed over time.Results Exposure to 4 mg/L BCDMH post-fertilization was sufficient to induce a number of developmental malformations,such as edema,axial malformations,and reductions in heart rate and hatching rate.The no observable effects concentration of BCDMH on zebrafish embryo was 0.5 mg/L.After 96 h exposure,the 50% lethal concentration (95% confidence interval (CI)) of BCDMH on zebrafish embryo was 8.10 mg/L (6.15-11.16 mg/L).The 50% inhibitory concentration (95% CI) of BCDMH on hatching rate was 7.37 mg/L (6.33-8.35 mg/L).Histopathology showed two types of responses induced by BCDMH,defensive and compensatory.The extreme responses were marked hyperplasia of the gill epithelium with lamellar fusion and epidermal peeling.The histopathologic changes in the gills after 10 days exposure were accompanied by significantly higher catalase activity and lipid peroxidation.Conclusion These results have important implications for studies on the toxicity and use of BCDMH and its analogs. | LI WanFang WEI JinFeng JIN HongTao HUANG MingFang ZHANG JingXuan LI ChengHe CHEN ChaoJie LIU Chang WANG AiPing | 2011 | Biomedical and Environmental Sciences2011，24，4： | 2 |
| 9 | Effect of sludge fasting/feasting on growth of activated sludge cultures 显示文摘 | ChenGH Yip W K Mo H K | 2001 | Water Research2001，35，4： | 1 |
| 10 | UsingLiDARdatatomeasurethethreedimensiongreenbiomassinBeijingofChina显示文摘 | ChengH MatteoC ZhongkeF etal | 2013 | PLOSONE2013，8，10： | 1 |
| 11 | Thermal deformation of machining center due to temperature change in the environment显示文摘 | Moriwaki Toshimichi Zhao Chenghe | 1991 | Transactions of the Japan Society of Mechanical Engineers1991，57，539： | 1 |
| 12 | Theresearchonforestrybiomassbasedon3Dlaserscanningtechnology显示文摘 | ChengH ZhongkeF JinjunY etal | 2012 | AdvancedScienceLetters2012，17，5： | 1 |
| 13 | Tensile behavior and fracture in nickel and carbon doped nanocrystalline nickel 显示文摘 | Chenghe Xiao Mirshams R A Whang S H | 2001 | Materials Science and Engineering A2001，301，： | 1 |
| 14 | Re - use of water treatment works sludge to enhance particulate pollutant removal from sewage 显示文摘 | GUANXH CHENGH SHANG C | 2005 | Water Research2005，39，15： | 1 |
| 15 | A new type V toxin- antitoxin system where mRNA for toxin GhoT is cleaved by anti- toxin GhoS显示文摘 | WangX Lord D M ChengH Y | 2012 | Nat Chem Biol2012，8，10： | 1 |
| 16 | Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice显示文摘 | ChengH WangH FanX | 2012 | Kidney Int2012，82，11： | 1 |
| 17 | MechanicalandelecGtricalpropertiesofaMWNT/epoxycomposite显示文摘 | AllaouiA BaiS ChengH M etal | 2002 | ComposGitesScienceTechnology2002，62，15： | 1 |
| 18 | Properties of pregelatinized rice flour-made by hot air or gum puffing显示文摘 | LaiH M ChengH H | 2004 | International Journal ofFood Science and Technology2004，，39： | 1 |
| 19 | Proteomic analysis of apoptosis initiation induced by all- trans retinoic acid in human acute promyelocytic leukemia cells显示文摘 | WangJ ChengH etal | 2001 | Electrophoresis2001，22，14： | 1 |
| 20 | Tining and structuure of the Younger Dryas event in northern China显示文摘 | MAZB CHENGH TANGM EDWARDSRL LIHC YOUCF DUAN W H WANG X KELLY M J | 2012 | Quaternary Sciences Reviews2012，41，2： | 1 |
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