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| 1 | Estimation on dynamic release of phosphorus from wind-induced suspended particulate matter in Lake Taihu显示文摘Through man-made disturbance experiments, the corresponding relationships be-tween suspended particulate matter (SPM) and wind speed in different lake areas were simu-lated, the physicochemical formal transformation and biological mineralizing and decaying processes of phosphorus in SPM were studied, the contribution of phosphorus transformation to phosphorus loading of the water of Lake Taihu was quantitatively estimated. The results show that about 0.44 t·a-1 loading in Lake Taihu mainly comes from phosphorus-releasing action of SPM in physicochemical transformed to soluble reactive phosphorus (SRP), and the contribution mainly from biological mineralizing and decaying was about 425.8 t·a-1, which is equal to 15.0% of the total external loading of Lake Taihu, namely 4.7—7.5 times as much as SRP loading en-tering the lake by the rivers; thus it is the important source in dynamical internal loading of the lake. The determining factors for dynamical internal loading in lakes are organic phosphorus content in suspended solid and its biological transition availability. | FAN Chengxin1, ZHANG Lu1,2, QIN Boqiang1, WANG Sumin1, HU Weiping1 & ZHANG Chen1 1. Taihu Lake Laboratory for Ecosystem Research, Nanjing Institute of Geography & Limnology, Chinese Academy of Sciences, Nanjing 210008, China 2. Graduate School of Chinese Academy of Sciences, Beijing 100039, China | 2004 | Science China Earth Sciences2004，47，8： | 24 |
| 2 | Prognosis of 980 patients with gastric cancer after surgical resection显示文摘Background and Objective: Although surgery is the only possible means to cure gastric cancer, the prognosis is often discrepant. The American Joint Committee on Cancer/International Union against Cancer (AJCC/UICC) published the TNM classification of Malignant Tumors (seventh edition) for gastric cancer recently. This study aimed to use this new edition staging system to investigate the prognostic factors for gastric cancer. Methods: The clinicopathologic data of 980 patients with gastric cancer treated by surgical resection in our hospital between January 2000 and December 2006 were analyzed retrospectively. The overall survival rate was determined by using Kaplan-Meier method and log-rank test was used to determine significance. The prognosis was analyzed using univariate analysis and multivariate analysis with the Cox proportional hazards model. The 6th and 7th edition AJCC/UICC TNM staging systems were used to compare the survival outcomes for the cohort of patients. Results: The overall 1-, 3-, 5-year survival rates for the whole group were 82.5%, 58.7%, and 52.6%. The 5-year survival rates for patients with pTNM stage I, II, III, and IV disease classified by the 7th edition staging system were 93.2%, 72.4%, 39.1%, and 5.2%, respectively. In both univariate analysis and Cox multivariate analysis, age, tumor site, tumor size, histological type, resection type, radical resection, lymphatic/venous invasion, depth of invasion, nodal status, metastasis, retrieved lymph nodes, metastatic lymph node ratio, and adjuvant chemotherapy were prognostic factors with these patients. Conclusion: Compared with the 6th edition system, the new edition of TNM staging system for gastric cancer can accurately predict the survival after operation. | Wei Wang1,2, Yuan-Fang Li1,2, Xiao-Wei Sun1,2, Ying-Bo Chen1,2, Wei Li1,2, Da-Zhi Xu1,2, Xuan-Xiang Guan1,2, Chun-Yu Huang1,2, You-Qing Zhan1,2, Zhi-Wei Zhou1,2 1 State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China 2 Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China | 2010 | Chinese Journal of Cancer2010，29，11： | 24 |
| 3 | Management of traumatic hemothorax by closed thoracic drainage using a central venous catheter显示文摘Objective:To evaluate the efficacy and safety of the treatment of traumatic hemothorax by closed pleural drainage using a central venous catheter(CVC),compared with using a conventional chest tube.Methods:A prospective controlled study with the Ethics Committee approval was undertaken.A total of 407 patients with traumatic hemothorax were involved and they were randomly assigned to undergo closed pleural drainage with CVCs(n=214) or conventional chest tubes(n=193).The Seldinger technique was used for drainage by CVC,and the conventional technique for drainage by chest tube.If the residual volume of the hemothorax was less than 200 ml after the daily volume of drainage decreased to below 100 ml for two consecutive days,the treatment was considered successful.The correlative data of efficacy and safety between the two groups were analyzed using t or chi-squared tests with SPSS 13.0.A P value of less than 0.05 was taken as indicating statistical significance.Results:Compared with the chest tube group,the operation time,fraction of analgesic treatment,time of surgical wound healing,and infection rate of surgical wounds were significantly decreased(P<0.05) in the CVC group.There were no significant differences between the two groups in the success rate of treatment and the incidence of serious complications(P>0.05),or in the mean catheter/tube indwelling time and mean medical costs of patients treated successfully(P>0.05).Conclusions:Management of medium or large traumatic hemothoraxes by closed thoracic drainage using CVC is minimally invasive and as effective as using a conventional large-bore chest tube.Its complications can be prevented and it has the potential to replace the large-bore chest tube. | Jian-hua YI1,Hua-bo LIU2,Mao ZHANG1,Jun-song WU1,Jian-xin YANG1,Jin-ming CHEN1,Shan-xiang XU1,Jian-an WANG1(1Department of Emergency,the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,China)(2Department of Emergency,Zhoushan Hospital of Zhejiang Province,Zhoushan 316004,China) | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 18 |
| 4 | Inhibition of hepatitis B virus by oxymatrine in vivo显示文摘AIM To investigate the anti-HBV effect ofoxymatrine (oxy) in vivo.METHODS HBV transgenic mice were producedby micro-injection of a 4.2kb fragmentcontaining the complete HBV genomes.Expression level of HBsAg and HBcAg in thetransgenic mice liver was determined byimmunohistochemical assay.RESULTS Four groups (6 mice in each group)were injected intraperitoneally with oxy at thedosage of 100,200, and 300 mg/kg or with salineonce a day for 30 days. Both HBsAg and HBcAgwere positive in livers of all the six mice in thecontrol group (injected with saline), and werepositive in livers of two mice in 100 mg/kg groupand 300mg/kg group. In 200mg/kg group,HBsAg and HBcAg were negative in livers of allthe six mice. Based on the results, 200 mg/kg isthe ideal dosage to explore the effect of oxy atdifferent time points. According to the oxytreatment time, mice were divided into fourgroups: 10 d, 20 d, 30 d and 60 d (4 mice in eachgroup). Each mouse underwent liver biopsy twoweeks before the treatment of oxy. Down-regulation of HBsAg and HBcAg appeared aftertreatment of oxymatrine for 10 d and 20 d, Dane-like particles disappeared after the treatment ofoxy for 20d under electron microscopy,however, the expression level of HBsAg andHBcAg returned to normal 60 d later after oxytreatment.CONCLUSION oxymatrine can reduce thecontents of HBsAg and HBcAg in transgenic miceliver, longer treatment time and larger dosagedo not yield better effects. | Xiao Song Chen1 Guo Jun Wang1 Xiong Cai1 Hong Yu Yu2 Yi Ping Hu3 1Department of Infectious Diseases, Changzheng Hospital, the Second Military Medical University, Shanghai 200003, China2Department of Pathology, 3Department of Cell Biology, Department of Basic Medicine, the Second Military Medical University, Shanghai 200433, China | 2001 | World Journal of Gastroenterology2001，7，1： | 13 |
| 5 | Single-nucleotide polymorphisms among microRNA:big effects on cancer显示文摘MicroRNAs(miRNAs) are small non-coding RNAs that regulate gene expression at the transcriptional or posttranscriptional level.Many miRNAs are found to play a significant role in cancer development either as tumor suppressor genes or as oncogenes.Examination of tumor-specific miRNA expression profiles in diverse cancers has revealed widespread deregulation of these molecules,whose loss and overexpression respectively have diagnostic and prognostic significance.Genetic variations,mostly single-nucleotide polymorphisms(SNPs) within miRNA sequences or their target sites,have been found to be associated with many kinds of cancers.In this review,we summarize the current knowledge of miRNAs including their biogenesis and role in cancer development,and finally,how SNPs among miRNAs affect miRNA biogenesis and contribute to cancer. | Feng-Ju Song1,2 and Ke-Xin Chen1,2 Department of Epidemiology and Biostatistics,1Tianjin Medical University Cancer Hospital and Institute,Tianjin 300060,P.R.China Key Laboratory of Breast Cancer Prevention and Therapy,2Tianjin Medical University,Ministry of Education,Tianjin 300060,P.R.China | 2011 | Chinese Journal of Cancer2011，30，6： | 11 |
| 6 | Effects of short-term low temperatures on photosystem Ⅱ function of samara and leaf of Siberian maple (Acer ginnala) and subsequent recovery显示文摘Samara is the reproductive organ (seed) for many tree species in arid land in northwestern China. It is ecologically important in population development due to its dispersal function. However, information on its photosynthesis and effect of environmental stresses on its photosynthesis is still very limited. In the present study, responses of photosystem II (PSII) activity in samara and leaf of Siberian maple to short-term chilling/freezing and subsequent recovery potential were comparatively investigated by using polyphasic fluorescence test. The samara had more efficient photosynthesis (Fv/Fm and PIABS) and more efficient electron transport (φEo) but lower energy dissipation (DIo/RC) than leaf. Generally, the PSII performance and the electron transport for both samara and leaf were inhibited under low temperature stress, accompanied by an increase of energy dissipation in PSII reaction centers (RCs). PSII of both samara and leaf was not markedly affected by chilling and could acclimate to chilling stress. Short-term freezing could completely inhibit PSII activity in both samara and leaf, indicated by the drop of values of Fv/Fm, PIABS, φEo to zero. PSII functional parameters of short-term dark frozen samara could be largely recovered whereas those of frozen leaf could not be recovered. The higher tolerance of samara to short-term low temperature stress than leaf is of great ecological significance for seed development, population establishment of Siberian maple. | XiangLiang PAN1, DaoYong ZHANG1,2, Xi CHEN1, Li LI1, GuiJin MU1, LanHai LI1, AnMing BAO1, Jing LIU2, HuaiSong ZHU1, WenJuan SONG1, JianYing YANG1, JunYong AI1 1 Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China 2 State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550000, China | 2009 | Journal of Arid Land2009，1，1： | 10 |
| 7 | Study on interaction between microtubule associated protein tau and prion protein显示文摘Microtubule-associated protein tau is considered to play roles in many neurodegenera-tive diseases including some transmissible spongiform encephalopathies.To address the possible molecular linkage of prion protein(PrP) and tau,a GST-fusion segment of human tau covering the three-repeat region and various PrP segments was used in the tests of GST pull-down and immuno-precipitation.We found tau protein interacted with various style prion proteins such as native prion protein(PrPC) or protease-resistant isoform(PrPSc) .Co-localization signals of tau and PrP were found in the CHO cell tranfected with both PrP and tau gene.The domain of interaction with tau was located at N-terminal of PrP(residues 23 to 91) .The evidence of molecular interactions between PrP and tau protein highlights a potential role of tau in the biological function of PrP and the pathogenesis of TSEs. | HAN Jun1,ZHANG Jin1,2,YAO Hailan1,3,WANG Xiaofan1,LI Feng1,CHEN Lan1,4,GAO Chen1,GAO Jianmei1,NIE Kai1,ZHOU Wei1 & DONG Xiaoping11.State Key Laboratory for Infectious Diseases Prevention and Control,National Institute for Viral Disease Control and Pre-vention,Chinese Center for Disease Control and Prevention,Beijing 100052,China 2.School of Medicine,Xi’an Jiao-Tong University,Xi’an 710061,China 3.Tong-Ji Medical College,Hua-Zhong University of Science and Technology,Wuhan 430030,China 4.National Laboratory of Medical Molecular Biology,Institute of Basic Medical Science,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100005,China | 2006 | Science China(Life Sciences)2006，49，5： | 10 |
| 8 | Senescence-like changes induced by expression of p21^(Waf1/Cip1) in NIH3T3 cell line显示文摘P21Waf1/Cip1 is a potent cyclin-dependent kinase inhibitor. As a downstream mediator of p53, p21Waf1/cip1involves in cell cycle arrest, differentiation and apoptosis. Previous studies in human cells provided evidencefor a link between p21Waf1/cip1 and cellular senescence. While in murine cells, the role of p21Waf1/Cip1is indefinite. We explored this issue using NIH3T3 cells with inducible p21Waf1/cip1 expression. Induc-tion of p21Waf1/Cip1 triggered G1 growth arrest, and NIH3T3-p21 cells exhibited morphologic features,such as enlarged and flattened cellular shape, specific to the senescence phenotype. We also showed thatp21Waf1/Cip1-transduced NIH3T3 cells expressedβ-galactosidase activity at pH 6.0, which is known to bea marker of senescence. Our results suggest that p21Waf1/cipx can also induce senescence-like changes inmurine cells. | XI CHEN1, WEI ZHANG2, YUN FEI GAO1, XIAO QIN SU1, ZHONG HE ZHAI1,*1 College of Life Sciences, Peking University, Beijing 100871, China2 The Key Laboratory of Cell Proliferation and Regulation Biology of the Ministry of Education, College of Life Sciences, | 2002 | Cell Research2002，12，4： | 9 |
| 9 | Correlation analysis between loss of heterozygosity at chromosome 18q and prognosis in the stage-Ⅱ colon cancer patients显示文摘Background and Objective: Colorectal cancer is one of the most common malignant cancers in the world. Although the clinicopathologic staging is the golden criterion for the prognosis at present, the optimum prognostic criteria for colorectal cancer should be a combination of the clinicopathologic staging and the molecular markers. However, there are currently no molecular markers available for the prognosis of colorectal cancer. Several tumor-suppressor genes associated with colorectal cancer have been mapped at the 18q21-23 region. In this study we detected the frequency of loss of heterozygosity (LOH) at chromosome 18q and investigated the relationship between LOH and clinicopathologic features and its prognostic value for patients with stage Ⅱ colon cancer. Methods: A total of 106 samples of tumor tissues and corresponding normal mucosa from patients with sporadic stage-Ⅱ colon cancer were included in this study. All the samples were formalin-fixed and paraffin-embedded. DNA was extracted from tumor tissues and LOH of D18S474, D18S55, D18S58, D18S61 and D18S64 at chromosome 18q was analyzed using polymerase chain reaction (PCR), polyacrylamide gel-electrophoresis, and DNA sequencing method. Multivariate analysis for association between LOH and prognosis in colon cancer patients was performed with Cox proportional hazards regression model. Results: The median follow-up time was 68 months. For 106 patients, 5-year survival rate was 83.6%, which was associated with age and gross tumor type (P = 0.011 and 0.034, respectively). Among 102 patients who were eligible for LOH information, the overall frequency of LOH is 49.0% (50/102), and that of LOH at 5 microsatellite loci of D18S474, D18S55, D18S58, D18S61, and D18S64 was 30.2% (26/86), 23.4% (18/77), 28.6% (20/70), 35.0% (28/80), and 20.8%(15/72), respectively. The occurrence of LOH was significantly associated with tumor location and histopathologic grade (P = 0.023, 0.016 and 0.005, respectively). LOH was more frequent on the left-side, poorly-differentiated adenocarcinoma, and nonmucinous colon cancers. The occurrence of 18q-LOH was significantly associated with 5-year overall survival rate and disease free survival rate (P = 0.008 and 0.006, respectively). The occurrence of 18q-LOH at the loci of D18S474 and D18S61 was significantly associated with 5-year overall survival rate (P = 0.010 and 0.005, respectively). The multivariate analysis showed that only the occurrence of 18q-LOH was significantly associated with prognosis (P = 0.021). Conclusions: There is a high occurrence of LOH at the loci of 18q. The expression of LOH is significantly associated with tumor location and histopathologic grade. The occurrence of 18q-LOH is an independent poor prognostic factor for the patients with stage-Ⅱ colon cancer. | Wei Wang1,2, Yuan-Fang Li1,2, Xiao-Wei Sun1,2, Gong Chen1,3, You-Qing Zhan1,2, Chun-Yu Huang1,2, De-Sen Wan1,3, Zhi-Zhong Pan1,3, Zhi-Wei Zhou1,2 1 State Key Labortary of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China 2 Department of Gasrtic and Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China 3 Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China | 2010 | Chinese Journal of Cancer2010，29，8： | 7 |
| 10 | The Quantitative Analysis of Land Use Structure Characteristics of County in Mountainous Areas in Sichuan Province of China——A Case Study of Rong County显示文摘Based on the data concerning detailed survey on land in the year 2009 and land change in the year 2010 in Rong County,a mountainous region of Sichuan Province,by using quantitative geographical model,we conduct quantitative analysis of the status quo of land use in Rong County in terms of land use diversification,land use centralization,land use combination type,land use geographic significance and comprehensive use degree of land use.The results show some characteristics as follows.Firstly,land use in study area displays prominent characteristic of diversification;there is a high degree of completeness land use type;there is a great similarity among towns.Secondly,there is limited combination number of land use type;mostly the combination number of the towns is 2-3;the holistic function of regional land is fragile;the proportion of farmland areas is big,reaching 40.09%;the land use type of 21 towns is farmland.Thirdly,the towns with prominent characteristic of diversification of land use in Rong County,have low degree of centralization of land use and relatively big combination number of land use type,and vice versa.Fourthly,the type and quantity of agricultural land resources with geographical significance are relatively complete with nothing missing;it abounds in untapped land,but the overall index values of land use are all smaller than 300,with low overall use degree of land. | ZHOU Wei1,2,WANG Chen1,2,SONG Xing1,2,DENG Liang-ji1,2 1.College of Resource and Environment,Sichuan Agricultural University,Ya’an 625014,China 2.Key Laboratory of Land Information in Sichuan Province,Ya’an 625014,China | 2011 | Asian Agricultural Research2011，3，5： | 6 |
| 11 | A Novel Dimeric Coumarin from Clausena lenis显示文摘A novel dimeric coumarin (1), a dimeric of seselin named diseselin A, was isolated from the aerial part of Clausena lenis. The structure was elucidated based on the MS, 1D and 2D NMR data. | Hong Ping HE1, Shun Ting CHEN1, Yue Mao SHEN1, Chang Xiang CHEN1, Yi Bin ZHAO1, Xiao Jiang HAO 1,2 * 1 The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 2The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002 | 2003 | Chinese Chemical Letters2003，14，11： | 5 |
| 12 | Antiangiogenic therapy:a novel approach to overcome tumor hypoxia显示文摘Hypoxia is a common phenomenon in solid tumors. Resistance of hypoxic tumor cells to radiation is a significant reason of failure in the local control of tumors. The growth and metastasis of solid tumors rely on blood vessels. Antiangiogenic agents mainly target tumor blood vessels, and radiation therapy mainly targets tumor cells. Combination of antiangiogenic treatment and radiation exhibits synergistic effect, which improves the response of tumors to radiation therapy. The mechanisms of interaction between antiangiogenic agents and ionizing radiation are complex and involve interactions between tumor cells and tumor microenvironment, including tumor oxygenation, stroma, and vasculature. The original mechanism of antiangiogenesis is to induce ischemia and hypoxia in tumors, thereby, 'starve' the tumors. However, recently, emerging data suggest that antiangiogenic agents could reduce the proportion of hypoxic cells through normalizing tumor vasculature, decreasing oxygen consumption, and other mechanisms. The use of antiangiogenic agents provides a new approach to overcome the hypoxia problem, and ultimately improves the efficacy of radiation therapy. In this review, we discuss tumor hypoxia, tumor angiogenesis and its regulation, mechanisms of antiangiogenic therapy combined with radiation therapy, and how antiangiogenic therapy overcomes tumor hypoxia. | Fang Peng1,2, Ming Chen1,2 1 State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China 2 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China | 2010 | Chinese Journal of Cancer2010，29，8： | 5 |
| 13 | THREE-DIMENSIONAL NUMERICAL MODELINGOF COHESIVE SEDIMENT TRANSPORT BY TIDAL CURRENTIN PEARL RIVER ESTUARV显示文摘A three-dimensional numerical model of suspended sediment transport taking into account the effects of cohesiveness between sediments is presented. An efficient operator splitting scheme is employed to solve the equations of mass conservation, momentum and suspended sediment transport. The splitting method partitions a time step into three fractional time steps according to physical phenomena. In the first step, advection and Coriolis force are solved by Eulerian-Lagrangian method (ELM). Horizontal diffusion is approximated by implicit finite element method (FEM) for each horizontal layer in the second step. In the last step, vertical diffusion and pressure gradient are discretized by implicit finite difference method (FDM) for each nodal column. The continuity equation is solved by implicit FEM within an entire time step. The sigma coordinate system for vertical columns and nine-node isoparameteric finite elements for horizontal planes are employed in the model. Empirical functions specifically developed for cohesive sediments in China have been incorporated into the model. The model has been applied to investigate the suspended sediment concentration and seabed evolution in the Pearl River Estuary (PRE) in China. Computed results show that the distribution of sediment concentration and seabed evolution is in agreement with field measurements. In addition, the effect of the size of time step on result is discussed. The computed result shows that larger time steps can be used in this model for saving computation time without losing much accuracy. | Yong CHEN1, Onyx W.H. WAI2, Y. S. Li3 and Qimiao LU4 (l 2,3 Department of Civil and Structural Engineering, The Hong Kong Polytechnic University. Hung Hom, Kowloon, Hong Kong 4,Department of Civil Engineering, Daltech, Dalhousie University, Halifax, Can | 1999 | International Journal of Sediment Research1999，14，2： | 4 |
| 14 | Studies on New Additions to 5-Methoxy-2 (5H)-Furanone: 1, 4-Addition of Grignard Reagents, and 1,3-Dipolar Cycloaddition of Silyl Nitronates显示文摘Addition reaction of Grignard’s reagent to 5-methoxy-2(5H)-furanone 1 was accomplished, which provided a new possible route for synthesizing β-alkyl-γ-alkyloxy-γ-butyrolactone. A novel concise method of preparing fused heterocyclic compounds was offered by 1,3-dipolar cycloaddition reaction of silyl nitronates to 1. | Zhao Yang WANG2, Jia Ling CUI3, Bao Shan DU1*, Qing Hua CHEN1 1Department of Chemistry, Beijing Normal University, Beijing 100875 2Present address: Dept. of Chem., South China Nor. Univ, Guangzhou 510631 3Present address: School of Pharm., Beijing Univ, | 2001 | Chinese Chemical Letters2001，12，4： | 3 |
| 15 | Synthesis and Antitumor Activity of4β-(1,2,3-Triazol-1-yl) podophyllotoxins显示文摘Three 4β-(1,2,3-triazol-1-yl) podophyllotoxins 2~4 have been synthesized and testedtar their antitumor activity in vitro. The compound 3 was found to be much more cytotoxic than theclinically used etoposide (VP-16) against L 1210 cells. | Chang Nian CAO~2 Yu Yin CHEN1 Yan Guang WANG1 Yao Zu CHEN(1Department of Chemistry, Zhejiang University, Hangzhou 310027)(2Department of Applied Chemistry, Qinghai University, Xining 810000) | 1999 | Chinese Chemical Letters1999，10，12： | 3 |
| 16 | Isolation and functional analysis of a Brassica junea gene encoding a component of auxin efflux carrier显示文摘Polar auxin transport plays a divergent role in plant growth and developmental processes including rootand embryo development, vascular pattern formation and cell elongation. Recently isolated Arabidopsispin gene family was believed to encode a component of auxin efflux carrier (Galweiler et al, 1998). Basedon the Arabidopsis pin1 sequence we have isolated a Brassica juncea cDNA (designated Bjpinl), whichencoded a 70-kDa putative auxin efflux carrier. Deduced BjPIN1 shared 65% identities at protein level withAtPIN1 and was highly homologous to other putative PIN proteins of Arabidopsis (with highest homologyto AtPIN3). Hydrophobic analysis showed similar structures between BjPIN1 and AtPIN proteins. Presenceof 6 exons (varying in size between 65 bp and 1229 bp) and 5 introns (sizes between 89 bp and 463 bp)in the genomic fragment was revealed by comparing the genomic and cDNA sequences. Northern blotanalysis indicated that Bjpinl was expressed in most of the tissues tested, with a relatively higher levelof transcript in flowers and a lower level in root tissues. Promoter-reporter gene fusion studies furtherrevealed the expression of Bjpinl in the mature pollen grains, young seeds, root tip, leaf vascular tissue andtrace bundle, stem epidermis, cortex and vascular cells. BjPIN1 was localized on the plasma membraneas demonstrated through fusion expression of green fluorescent protein (GFP). Auxin efflux carrier activitywas elevated in transgenic Arabidopsis expressing BjPIN1. | WEI MIN NI1,2, XIAO YA CHEN1, ZHI HONG XU1,2, HONG WEI XUE1.2,*1 National Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences2 Partner Group of Max-Pla | 2002 | Cell Research2002，12，4： | 2 |
| 17 | Two New Arylnaphthalene Lignan Glycosides from Mananthes patentiflora显示文摘Two new diphyllin glycosides, mananthoside A (1) and B (2), together with six known compounds, were isolated from the ethanolic extract of the whole plants of Mananthes patentiflora. Their structures were determined on the basis of chemical and spectral evidences. | Bin CHEN1, Yan LIU1, Chun FENG2, Bo Gang LI1, Guo Lin ZHANG1* 1Chengdu Institute of Biology, the Chinese Academy of Sciences, Chengdu 610041 2Analyzing and Testing Center, Sichuan Normal University, Chengdu 610064 | 2002 | Chinese Chemical Letters2002，13，10： | 2 |
| 18 | AN IRREVERSIBILITY PHENOMENA IN ELECTRICAL CONDUCTIVITY OF THE MELTS IN SODIUM IRON PHOSPHATE SYSTEM显示文摘Theelectricalresistivityofsodium iron phosphate melts wasinvestigated asa functionoftem peratureand composition. Irreversibility was found in thetemperature dependent electricalresistivityinthe melts withlow Na2 Ocontentduringtheheating andcoolingcycle. Theirre versibility wasreduced withincreasing Na2 Ocontent. Theelectricalresistivity tendedto de creaseslightly withtime. Theelectricalconduction ofthe meltscontainingsimulatedindustry waste wassimilartothatofthe melts withsimilarsodacontent. Thetemperature dependent electricalresistivity and activation energy ofthese melts was discussed using the Motttheory and wascorrelatedtothe Fe(II) contentinthe | F. Y. Chen1)and E. D. Delber2) 1) State Key Laboratory of Solidification Process,Northwestern Polytechnic University ,Xi’an 710072 ,China 2) Department of Ceramics Engineering , University of Missouri Rolla, Rolla, Mo 654301 , USA | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，4： | 2 |
| 19 | (Et_4N)_2[Fe_4(SPh)_10] Stimulated S_(RN)1 Reactions of α-Bromonaphth-alene with Pinacolone Carbanion显示文摘The (Et4N)2[Fe4(SPh)10] stimulated reaction of α-bromonaphthalene with pinacolone carbanion in DMSO leads to the formation of 1-(α-naphthyl)pinacolone. The reaction is suggested in terms of SRN1 mechanism of aromatic nucleophillic substitution and has potential value in synthesis to obtain (-substituted naphthalene derivaties. | Zhao ZHANG1*, Ya Ling GONG1, Yu WANG1, Zhao Bin CHEN1, Pei Lan WANG2 1Department of Chemistry, Shanxi University, Taiyuan 030006 2Test and Analysis Center of Shanxi University, Taiyuan 030006 | 2001 | Chinese Chemical Letters2001，12，2： | 2 |
| 20 | Two New Xanthone Glycosides from Swertia Tetraptera显示文摘Two new xanthone glycosides, tetraswerosides A and B, were isolated from the whole plant of Swertia tetraptera. Their structures were determined as 3-O-■-D-glucopyranosyl-1-hydroxy-4,7- dimethoxyxanthone and 3-O-[■-D- xylopyranosyl -(1→6)-■-D-glucopyranosyl]-1-hydroxy-4,7- dimethoxyxanthone by spectroscopic methods. | Zhi Xin LIAO1,2, Yu Lin LI2, Ming Kui WANG3, Li Sheng DING3*,Yao Zu CHEN1 1 State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000 2Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining 810001 3Chengdu | 2001 | Chinese Chemical Letters2001，12，5： | 2 |
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