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| 1 | Unique characteristics of the genetics epidemiology of amyotrophic lateral sclerosis in China显示文摘Continual discoveries of new genes and unraveling the genetic etiology in amyotrophic lateral sclerosis(ALS) have provided greater insight into the underlying pathogenesis in motor neuron degeneration, as well as facilitating the disease modeling and the testing of targeted therapeutics. While, the genetic etiology accounted for two-thirds of FALS and approximately 11% of SALS in Caucasians. However, the contributions of these causative genes to ALS vary among different populations. Furthermore, the prominent difference between Chinese population and other ethnics remains a source of ongoing debate. We systemically reviewed genetics literature of Chinese ALS populations and updated the mutation frequencies of the main ALS-implicated genes aiming to determine the genetic features of ALS in Chinese population. We also reviewed the associations between ALSimplicated single nucleotide polymorphisms(SNPs) and the risk of ALS in Chinese population. A total of 116 studies were included in this analysis(86 gene mutation study articles and 30 SNPs study articles). The results showed that the overall gene mutation rates of ALS-related causative genes were 55.0% in familial ALS(FALS) and 11.7% in sporadic ALS(SALS) in Chinese population. In Chinese FALS, the highest mutation frequency was found in SOD1 gene(25.6%), followed by FUS(5.8%), TARDBP(5.8%), DCTN1(3.6%) and C9 orf 72(3.5%). In Chinese SALS, the highest mutation frequency was also identified in SOD1 gene(1.6%), followed by ANXA11(1.4%), FUS(1.3%), SQSTM1(1.0%), OPTN(0.9%) and CCNF(0.8%).The associations between several SNPs and risk of ALS were also reported in Chinese population. The genetic features of ALS in Chinese population are significantly different from those in Caucasian population, indicating an association between genetic susceptibility and origin of population. Further explorations are required to understand the gene complexity of ALS, including the contribution of most minor genes and the molecular mechanisms in ALS pathologies. | Qianqian Wei Xueping Chen Yongping Chen Ruwei Ou Bei Cao Yanbing Hou Lingyu Zhang Hui-Fang Shang | 2019 | Science China(Life Sciences)2019，62，4： | 7 |
| 2 | Exchange-coupling interaction and effective anisotropy in nanocomposite permanent materials显示文摘Taking Nd2Fe14B/α-Fe as example, the exchange-coupling interactions between magnetically soft and hard grains in nanocomposite permanent materials and their effects on the effective anisotropy of materials were investigated. The calculation results expressed that the exchange-coupling interactions are enhanced with the reduction of grain size, and the effective anisotropy of materials decreases with the reduction of gram size and the increase of magnetically soft phase component. The remanence and the effective anisotropy of materials possess the opposite variation trend with the change of grain size and phase ratio. The mean grain size should be in the range of 10-15 nm and the ratio of soft phase should be less than 50% for getting the magnet with high energy product. | Ruwei Gao Weicun Feng Wei Chen Biao Wang Guangbing Han Peng Zhang | 2002 | Chinese Science Bulletin2002，47，14： | 5 |
| 3 | Trace Amounts of Triple-Functional Additives Enable Reversible Aqueous Zinc-Ion Batteries from a Comprehensive Perspective显示文摘Although their cost-effectiveness and intrinsic safety,aqueous zinc-ion batteries suffer from notorious side reactions including hydrogen evolution reaction,Zn corrosion and passivation,and Zn dendrite formation on the anode.Despite numerous strategies to alleviate these side reactions have been demonstrated,they can only provide limited performance improvement from a single aspect.Herein,a triple-functional additive with trace amounts,ammonium hydroxide,was demonstrated to comprehensively protect zinc anodes.The results show that the shift of electrolyte pH from 4.1 to 5.2 lowers the HER potential and encourages the in situ formation of a uniform ZHS-based solid electrolyte interphase on Zn anodes.Moreover,cationic NH^(4+)can preferentially adsorb on the Zn anode surface to shield the“tip effect”and homogenize the electric field.Benefitting from this comprehensive protection,dendrite-free Zn deposition and highly reversible Zn plating/stripping behaviors were realized.Besides,improved electrochemical performances can also be achieved in Zn//MnO_(2)full cells by taking the advantages of this triple-functional additive.This work provides a new strategy for stabilizing Zn anodes from a comprehensive perspective. | Ruwei Chen Wei Zhang Quanbo Huang Chaohong Guan Wei Zong Yuhang Dai Zijuan Du Zhenyu Zhang Jianwei Li Fei Guo Xuan Gao Haobo Dong Jiexin Zhu Xiaohui Wang Guanjie He | 2023 | Nano-Micro Letters2023，15，6： | 2 |
| 4 | Relation between parity-check matrixes and cycles of associated tanner graphs显示文摘 | Chen Ruwei Huang Huawei Xiao Guozhen | 2007 | IEEE Commun Lett2007，11，8： | 1 |
| 5 | Diurnal drooling in Chinese patients with Parkinson’s disease显示文摘 | Ruwei Ou Xiaoyan Guo Qianqian Wei Bei Cao Jing Yang Wei Song Ke Chen Bi Zhao Xueping Chen Huifang Shang | 2015 | Journal of the Neurological Sciences . 2015 (1-2)2015，，1： | 1 |
| 6 | Diverse intracellular signalling systems used by growth hormone releasing hormone in regulating voltage-gated Ca2 + or K + channels in pituitary somatotropes显示文摘 | Chen Chen Xu Ruwei lain J Clarke | 2000 | Immunology and Cell Biology2000，，78： | 1 |
| 7 | 显示文摘 | Gao Ruwei Feng Weicun Chen Wei | 2002 | Chinese Science Bulletin2002，47，14： | 1 |
| 8 | Effective anisotropy and coercivity in nanocrystalline single-phase NdFeB permanent magnetic material显示文摘 | Guangbing Han Ruwei Gao Weicun Feng Hanqiang Liu Biao Wang Peng Zhang Wei Chen Wei Li Yongquan Guo | 2003 | Science in China Series G: Physics Mechanics and Astronomy2003，，4： | 1 |
| 9 | Generalized combining method for design of quasi-cyclic LDPC codes显示文摘 | Liu Yuanhua Wang Xinmei Chen Ruwei | 2008 | IEEE Communications Letters2008，12，5： | 1 |
| 10 | Generalized Combining Method for Design of Quasi-Cyclic LDPC Codes 显示文摘 | Liu Yuanhua Wang Xinmei Chen Ruwei | 2008 | IEEE Communications Letters2008，12，5： | 1 |
| 11 | Effective anisotropy and coercivity in nanocrystalline single-phase NdFeB permanent magnetic material显示文摘 | Guangbing Han Ruwei Gao Weicun Feng Hanqiang Liu Biao Wang Peng Zhang Wei Chen Wei Li Yongquan Guo | 2003 | Science in China Series G: Physics Mechanics and Astronomy2003，，4： | 1 |
| 12 | Prevalence and clinical correlates of drooling in Parkinson disease: A study on 518 Chinese patients显示文摘 | Ruwei Ou Xiaoyan Guo Qianqian Wei Bei Cao Jing Yang Wei Song Na Shao Bi Zhao Xueping Chen Huifang Shang | 2014 | Parkinsonism and Related Disorders2014，，： | 1 |
| 13 | 显示文摘 | Gao Ruwei Feng Weicun Chen Wei | 2002 | Chinese Science Bulletin2002，47，14： | 1 |
| 14 | BLECA: A Blockchain-Based Lightweight and Efficient Cross-Domain Authentication Scheme for Smart Parks显示文摘Smart parks serve as integral components of smart cities,where they play a pivotal role in the process of urban modernization.The demand for cross-domain cooperation among smart devices from various parks has witnessed a significant increase.To ensure secure communication,device identities must undergo authentication.The existing cross-domain authentication schemes face issues such as complex authentication paths and high certificate management costs for devices,making it impractical for resource-constrained devices.This paper proposes a blockchain-based lightweight and efficient cross-domain authentication protocol for smart parks,which simplifies the authentication interaction and requires every device to maintain only one certificate.To enhance cross-domain cooperation flexibility,a comprehensive certificate revocation mechanism is presented,significantly reducing certificate management costs while ensuring efficient and secure identity authentication.When a park needs to revoke access permissions of several cooperative partners,the revocation of numerous cross-domain certificates can be accomplished with a single blockchain write operation.The security analysis and experimental results demonstrate the security and effectiveness of our scheme. | Fengting Luo Ruwei Huang Yuyue Chen | 2023 | Computers, Materials & Continua2023，77，11： | 0 |
| 15 | Rare variant analysis of PLXNA1 in Parkinson’s disease in the Chinese population显示文摘Recently,p.Glu1121Ter in PLXNA1 was identified as po-tential cause for a patient with parkinsonism.However,no further replication has been conducted in a wider range of Parkinson’s disease(PD)cohorts.To evaluate the genetic association of PLXNA1 with PD,we systematically analyzed the rare protein-coding variants in 1,245 Chinese patients with whole exome sequencing. | Chunyu Li Ruwei Ou Yanbing Hou Junyu Lin Kuncheng Liu Qianqian Wei Xueping Chen Wei Song Bi Zhao Huifang Shang | 2023 | Genes & Diseases2023，10，4： | 0 |
| 16 | Therapeutic perspectives for adult soft tissue sarcoma—updates from the 2022 ASCO annual meeting显示文摘At the recent 2022 American Society of Clinical Oncology(ASCO)annual meeting,the latest progress was presented in clinical trials of various therapeutic modalities for adult soft tissue sarcoma(STS),including chemotherapy,targeted therapy,anti-immune checkpoint immunotherapy,and multiple combination treatments(Table 1).Generally,the development of clinical treatments for STS is relatively slow,owing to the complex pathological subtypes of sarcoma and their heterogeneous biological behaviors.Here,we briefly summarize updates from this year’s ASCO meeting and discuss the future therapeutic perspectives for unspecific STS. | Jilong Yang Yu Xu Yong Chen Tao Li Xiaowei Zhang Tu Hu Ruwei Xing Yun Yang | 2022 | Cancer Biology & Medicine2022，19，10： | 0 |
| 17 | The efficacies and biomarker investigations of antiprogrammed death-1 (anti-PD-1)-based therapies for metastatic bone and soft tissue sarcoma显示文摘Objective:Sarcomas are a group of rare malignancies with various subtypes.Patients with metastatic sarcoma who have failed traditional treatments can possibly achieve better prognoses from using novel therapies,including anti-programmed death-1(PD-1)-based therapies.Methods:We retrospectively analyzed clinical data of 24 metastatic sarcoma patients from June 15,2016 to December 30,2019.These patients mainly received angiogenesis inhibitors combined with anti-PD-1 therapy after they became resistant to traditional treatments.Furthermore,8 patients underwent panel DNA and whole transcript sequencing.Results:Six patients received 2 cycles of anti-PD-1 therapy and were included in the safety evaluation only group.The median follow-up time was 5.77 months.The median progression-free survival was 7.59 months,the overall response rate was 16.7%and the disease control rate was 55.6%.Based on whole exome and transcript sequencing data,there was no association between TMB,TNB,MSI,HLA-LOH,and PD-L1 expressions and sarcoma types with clinical responses.Immunotherapy efficacy and bioinformatics analyses indicated higher intratumoral heterogeneity(ITH)in progressive disease(PD)patients and lower ITH in partial response(PR)and stable disease patients.A higher percentage of immune cell infiltration,especially monocytes,was observed in PR patients.Active stromal gene expression was increased in PD patients but decreased in PR patients.Enrichment analysis revealed that an increased TGF-βsignaling pathway was reversely correlated with anti-PD-1 efficacy,while a decreased inflammatory response signaling pathway was positively correlated with anti-PD-1 efficacy.Conclusions:Our study showed PD-1 inhibitors combined with anti-angiogenesis agents were effective and well-tolerated.ITH,monocyte ratio,stroma subtypes,and the status of immune-associated signaling pathways may be related with anti-PD-1 based therapy. | Jia Lu Ting Li Zhichao Liao Hui Yu Yongtian Zhao Haixiao Wu Zhiwu Ren Jun Zhao Ruwei Xing Sheng Teng Yun Yang Xiangchun Li Kexin Chen Jonathan Trent Jilong Yang | 2022 | Cancer Biology & Medicine2022，19，6： | 0 |
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