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| 1 | Immune Responses in Wild-type Mice Against Prion Proteins Induced Using a DNA Prime-Protein Boost Strategy显示文摘Objective To break immune tolerance to prion (PrP) proteins using DNA vaccines.Methods Four different human prion DNA vaccine candidates were constructed based on the pcDNA3.1 vector:PrP‐WT expressing wild‐type PrP,Ubiq‐PrP expressing PrP fused to ubiquitin,PrP‐LII expressing PrP fused to the lysosomal integral membrane protein type II lysosome‐targeting signal,and PrP‐ER expressing PrP locating the ER.Using a prime‐boost strategy,three‐doses of DNA vaccine were injected intramuscularly into Balb/c mice,followed by two doses of PrP protein.Two weeks after the last immunization,sera and spleens were collected and PrP‐specific humoral and cellular immune responses evaluated by ELISA and ELISPOT tests.Results Higher levels of serum PrP antibodies were detected in mice vaccinated using the strategy of DNA priming followed by protein boosting.Of these,WT‐PrP,Ubiq‐PrP,and PrP‐LII induced significantly higher humoral responses.ELISPOT tests showed markedly increased numbers of IFN‐γ‐secreting T cells in mice vaccinated using the strategy of DNA priming followed by protein boosting after stimulation with recombinant PrP23‐90 and PrP23‐231.PrP‐ER inducedthe strongest T‐cell response.Conclusion Prion vaccines can break tolerance to PrP proteins and induce PrP‐specific humoral and cellular immune responses. | HAN YanLing LI Yuan SONG Juan WANG Ying SHI Qi CHEN Cao ZHANG BaoYun GUO Yan LI ChaoPing HAN Jun DONG XiaoPing | 2011 | Biomedical and Environmental Sciences2011，24，5： | 2 |
| 2 | Completely monotonic function associated with the Gamma functions and proof of Wallis' inequality显示文摘 | Chen Chaoping Qi Fen | 2005 | Tamkang Journal of Mathematics2005，36，4： | 1 |
| 3 | A complete monotonicity property of the gamma function显示文摘 | Qi Feng Chen Chaoping | 2004 | Journal of Mathe- matical Analysis and Applications2004，296，2： | 1 |
| 4 | quantum codes from concatenated algebraic geometric codes 显示文摘 | Chen Hao Ling San Xing Chaoping | 2005 | IEEE Trans Inf Theory2005，51，： | 1 |
| 5 | Monotonicity properties for generalized logarithmic means 显示文摘 | Chen Chaoping Qi Feng | 2004 | Aust J Math Anal App12004，1，2： | 1 |
| 6 | Monotonicity of ratio between the generalized logarithmic means 显示文摘 | Qi Feng Chen Shouxin Chen Chaoping | 2007 | Math Inequal Appl2007，10，3： | 1 |
| 7 | The monotonicity of the ratio between generalized logarithmic means 显示文摘 | Chen Chaoping | 2008 | J Math Anal Appl2008，345，1： | 1 |
| 8 | The Key Role ofpH Value in the Synthesis of Titanate Nanotubes-Loaded Manganese Oxides as a Superior Catalyst for the Selective Catalytic Reduction of NO with NH3 显示文摘 | Chen Xiongbo Cen Chaoping Tang Zhixiong | 2013 | Journal of Nanomaterials2013，7，： | 1 |
| 9 | Simultaneous removal of SO 2 and NO X by wet scrubbing using urea solution显示文摘 | Ping Fang Chaoping Cen Zhixiong Tang Peiyi Zhong Dingsheng Chen Zhihang Chen | 2010 | Chemical Engineering Journal2010，，1： | 1 |
| 10 | Quantum Codes Concatenated From Algebraic Geometric Codes 显示文摘 | Hao Chen San Ling Chaoping Xing | 2005 | IEEE Trans Inf Theory2005，51，： | 1 |
| 11 | A complete monotonicity property of the gamma function 显示文摘 | Qi Feng Chen Chaoping | 2004 | Journal of Mathe- matical Analysis and Applications2004，296，2： | 1 |
| 12 | Logarithmically completely monotonic functions relating to the gamma function 显示文摘 | Chen Chaoping Qi Feng | 2006 | Journal of Mathematical Analysis and Applications2006，321，1： | 1 |
| 13 | Influence of cerium ions on thermal bleaching of photo-darkened ytterbium-doped fibers显示文摘We studied the influence of cerium (Ce)ions on photo-darkening (PD)behavior in ytterbium/aluminum (Yb/Al)co-doped silica fibers at room and elevated temperatures.Low levels of PD was observed for Ce codoped Yb/Al fiber.And the Yb/Al co-doped fiber was completely bleached at -600℃.The addition of Ce ions as co-dopant can significantly lower the initial recovery and complete bleaching temperatures.The complete recovery temperature is -450℃ and -400℃ for Yb/Al/Ce low fiber and Yb/Al/Ce high fiber respectively.More importantly, Ce co-doping in Yb/Al fiber also decreases the heatinduced loss. | Xiaoxia LIU Chaoping LIU Gui CHEN Haiqing LI | 2018 | Frontiers of Optoelectronics2018，11，4： | 1 |
| 14 | Simultaneous removal of SO 2 and NO X by wet scrubbing using urea solution显示文摘 | Ping Fang Chaoping Cen Zhixiong Tang Peiyi Zhong Dingsheng Chen Zhihang Chen | 2010 | Chemical Engineering Journal2010，，1： | 1 |
| 15 | Quantum codes from concatenated algebraic-geometric codes显示文摘 | Chen Hao Ling San Xing Chaoping | 2005 | IEEE Trans Inform Theory2005，51，8： | 1 |
| 16 | Precoking selectiva-tion for improving benzene product purity in heavy aromat-ics transalkylation 显示文摘 | ChaoP H Lin H W Chen C H | 2008 | Applied Catalysis A : General2008，335，1： | 1 |
| 17 | Leadership styles and employees’ job-related attitudes: An empirical study on the mediating effects of reciprocity and trust显示文摘 | Liangding Jia Jiwen Song Chaoping Li Rongjun Cui Yongxia Chen | 2007 | Frontiers of Business Research in China2007，，4： | 1 |
| 18 | MICROSTRUCTURE AND MECHANICAL PROPERTIES OF ALUMINA COATINGS PLASMA-SPRAYED AT DIFFERENT SUBSTRATE TEMPERATURES显示文摘Alumina coatings are prepared by atmospheric plasma spraying through controlling the substrate temperature during spraying. The changes in microstructure and mechanical properties of the coatings prepared at different substrate temperatures are examined. The hardness and the elastic modulus of the coatings are measured by indentation methods. The results show that interlamellar bonding in the coatings is significantly improved with increasing the substrate temperature. Moreover, long through-thickness columnar grains form in the coatings when the substrate temperature reaches above 430℃. As a result, the cross-sectional hardness and the elastic modulus perpendicular to the coating surface increase with increasing the substrate temperature. | Yazhe Xing Chaoping Jiang Hong Chen Jianmin Hao | 2011 | Acta Mechanica Solida Sinica2011，24，5： | 0 |
| 19 | Performance and mechanism of CO_(2) absorption during the simultaneous removal of SO_(2) and NO_(x) by wet scrubbing process显示文摘The co-removal of CO_(2)while removing SO_(2)and NOxfrom industrial flue gas has great potential of carbon emission reduction but related research is lacking.In this study,a wet scrubbing process with various urea solutions for desulfurization and denitrification was explored for the possibility of CO_(2)absorption.The results showed that the urea-additive solutions were efficient for NOxand SO_(2)abatement,but delivered<10%CO_(2)absorption efficiency.The addition of Ca(OH)_(2)dramatically enhanced the CO_(2)absorption,remained the desulfurization efficiency,unfortunately restricted the denitrification efficiency.Among various operating parameters,pH of solution played a determining role during the absorption.The contradictory pH demands of CO_(2)absorption and denitrification were observed and discussed in detail.A higher pH of solution than 10 was favorable for CO_(2)absorption,while the oxidizing of NO to NO_(2),NO_(2)^(-)or NO_(3)^(-)by NaClO_(2)was inhibited in this condition.When7 | Peng Lu Xianhui Yan Lyumeng Ye Dingsheng Chen Dongyao Chen Jianhang Huang Chaoping Cen | 2024 | Journal of Environmental Sciences2024，，1： | 0 |
| 20 | Cooling and Crack Suppression of Bone Material Drilling Based on Microtextured Bit Modeled on Dung Beetle显示文摘In recent years,the number of patients with orthopedic diseases such as cervical spondylosis has increased,resulting in an increase in the demand for orthopedic surgery.However,thermal necrosis and bone cracks caused by surgery severely restrict the development and progression of orthopedic surgery.For the material of cutting tool processing bone in bone surgery of drilling high temperature lead to cell death,easy to produce the problem such as crack cause secondary damage effects to restore,in this paper,a bionic drill was designed based on the micro-structure of the dung beetle's head and back.The microstructure configuration parameters were optimized by numerical analysis,and making use of the optical fiber laser marking machine preparation of bionic bit;through drilling test,the mathematical model of drilling temperature and crack generation based on micro-structure characteristic parameters was established by infrared thermal imaging technology and acoustic emission signal technology,and the cooling mechanism and crack suppression strategy were studied.The experimental results show that when the speed is 60 m/min,the cooling effects of the bionic bit T1 and T2 are 15.31%and 19.78%,respectively,and both kinds of bits show obvious crack suppression effect.The research in this paper provides a new idea for precision and efficient machining of bone materials,and the research results will help to improve the design and manufacturing technology and theoretical research level in the field of bone drilling tools. | Yunsong Lian Xiande Chen Chaoping Xie Yangyang Long Fengtian Lin Wei Zhou Xuyang Chu | 2023 | Chinese Journal of Mechanical Engineering2023，36，2： | 0 |
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