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| 1 | Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats显示文摘Diabetic neuropathies are a family of nerve disorders caused by diabetes.Symptoms of the disease include nerve palsy,mononeuropathy,mononeuropathy multiplex,diabetic amyotrophy,painful polyneuropathy,autonomic neuropathy,and thoracoabdominal neuropathy.In this study,type 2 diabetes in rats was induced with nicotinamidestreptozotocin.Drug treatment was initiated on the d 15,with the combination regimen of metformin,pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin,amitriptyline and sitagliptin and led to significantly improved glycemic control,increased grip strength and paw jumping response on d 21,28 and 35(P < 0.001).Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21,28 and 35(P < 0.001).Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells,while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain.In conclusion,treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain,but causes an increase in grip strength and pain sensitivity,exhibits neural protection,and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. | Ashish Kumar Sharma Akash Sharma Rita Kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil Sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam | 2012 | The Journal of Biomedical Research2012，26，3： | 2 |
| 2 | Predicting outcome after multiple trauma:which scoring system显示文摘 | Chawda MN Hildebrand F Pape HC | 2004 | Care Injured2004，35，3： | 1 |
| 3 | Predicting outcome after multiple trauma:which scoring system显示文摘 | Chawda MN Hildebrand F Pape HC | 2004 | Injury2004，35，4： | 1 |
| 4 | Electrical and optical characteristics of Ni doped ZnS clusters显示文摘 | SONI H CHAWDA M BODAS D | 2009 | Materials Letters2009，63，910： | 1 |
| 5 | Predicting outcome after multiple trauma: which scoring system? 显示文摘 | Chawda MN Hildebrand F Pape HC | 2004 | Injury2004，35，4： | 1 |
| 6 | Predicting outcome after muhiple trauma : which scoring system 显示文摘 | Chawda MN Hildebrand F Pape HC | 2004 | Injury2004，35，4： | 1 |
| 7 | Surface-engineered gadolinium oxide nanorods and nanocuboids for bioimaging显示文摘Folic acid and D-gluconic acid-capped gadolinium oxide nanorods and nanocuboids were synthesized via co-precipitation method.Comparative study of relaxivity factor on the role of capping and morphology for enhancing contrast ability for T_(1) and T_(2) magnetic resonance imaging(MRI) was investigated.The obtained r_(2)/r_(1) ratio for folic acid and D-gluconic acid-capped gadolinium oxide nanorods and nanocuboids was 1.5 and 1.3,respectively.The nanocrystals were characterized and presented with properties such as good dispersity and stability required for standard contrast agent used in MRI.The characterization and the analysis of capping agent for nanocrystals suggest the preferable use of carbohydrate moieties with higher number of hydroxyl functional group reacted with urea and hydrogen peroxide for desired morphology and anisotropic growth.Thermogravimetric-differential thermal analysis(TG-DTA) illustrated the amount of capping,transition temperature from Gd(OH)3 to GdOOH and crystallization temperature from GdOOH to Gd2O3.These nanocrystals would be significant for other biomedical applications such as drug delivery when equipped with well-functionalized drug molecules. | Nitya Ramesh Chawda Santosh Kumar Mahapatra Indrani Banerjee | 2021 | Rare Metals2021，40，4： | 1 |
| 8 | Prevalence of beta hemolytic streptococci carrier rate among school children in Salem显示文摘 | Navneeth BV Ray N Chawda S | 2001 | Indian J Pediatr2001，68，10： | 1 |
| 9 | Pattern of premature degenerative changes of cervical spine in patients with spasmodic torticollis and the impact on the outcome ofselective peripheral denervation显示文摘 | Chawda SJ Munchau A Johnson D | 2000 | J Neurol Neurosurg Psychiatry2000，68，4： | 1 |
| 10 | Pattern of premature degenerative changes of the cervical spine in patients with spasmodic torticollis and the impact on the outcome of selective peripheral denervation显示文摘 | Chawda SJ Munchau A Johnson D | 2000 | J Neurol Neurosurg Psychiatry2000，68，： | 1 |
| 11 | Predicting outcome after multiple trauma: which scoring system?显示文摘 | M.N Chawda F Hildebrand H.C Pape P.V Giannoudis | 2003 | Injury2003，，4： | 1 |
| 12 | Predicting outcome after multiple trauma: which scoring system 显示文摘 | Chawda MN Hildebrand F Pape HC | 2004 | Injury2004，35，4： | 1 |
| 13 | A clinical study comparing epineph- rine 200/g or clonidine 90 g as adjuvants to local anaesthetic agent in brachial plexus block via supraclavicular approach显示文摘 | Chawda P M Sharma G | 2010 | J Anesth Clin Pharma2010，26，4： | 1 |
| 14 | The relationship between serum lipid levels and the risk of oral cancer显示文摘 | Jyoti G Chawda Shikha S | 2011 | Indian J Med Paediatr Oncol2011，32，1： | 1 |
| 15 | Computed tomographg of orbital dermoids: a 20 year review 显示文摘 | Chawda SJ Moseleg IF | 1999 | Chin Radid1999，54，12： | 1 |
| 16 | Predicting outcome after multiple trauma: which scoring system? 显示文摘 | Chawda MN Hildebrand F Pape HC | 2004 | Injury2004，35，4： | 1 |
| 17 | Biosynthesis ofthe carbohydrate antigenic determinants,Globo H,blood group H,and Lewis b : a role for prostate cancer cell alphal,2 - L - fuco-syltransferase显示文摘 | Chandrasekaran EV Chawda R Locke RD | 2002 | Glycobiology2002，12，3： | 1 |
| 18 | Predicting outcome after multiple trauma:which scoring system? 显示文摘 | Chawda MN Hildebrand F Pape HC | 2004 | Injury2004，35，4： | 1 |
| 19 | Predicting outcome after multiple trauma:which scoring system显示文摘 | Chawda M N Hildebrand F Pape H C | | 0，，04： | 1 |
| 20 | Clinical significance of total and lipid bound sialie acid levels in oral pre-cancerous conditions and oral cancer显示文摘 | Rajpura KB Pate1 PS Chawda JG | 2005 | J Oral Pathol Med2005，34，： | 1 |
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