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| 1 | Phase I study on the safety and preliminary efficacy of allogeneic mesenchymal stem cells in hypoxic-ischemic encephalopathy显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is a leading cause of morbidity and mortality in the adult as well as in the neonate,with limited options for treatment and significant dysfunctionality.AIM To investigate the safety and preliminary efficacy of allogeneic mesenchymal stem cells(MSCs)in HIE patients.METHODS Patients who had HIE for at least 6 mo along with significant dysfunction and disability were included.All patients were given Wharton’s jelly-derived MSCs at 1×106/kg intrathecally,intravenously,and intramuscularly twice a month for two months.The therapeutic effects and prognostic implications of MSCs were evaluated by multiple follow-ups.Functional independence measure(FIM),modified Ashworth,and Karnofsky scales were used to assess any side effects,neurological and cognitive functions,and overall outcomes.RESULTS The 8 subjects included in the study had a mean age of 33.25±10.18 years.Mean HIE exposure and mean post-HIE durations were 45.63±10.18 and 19.67±29.04 mo,respectively.Mean FIM score was 18.38±1.06,mean modified Ashworth score was 43.5±4.63,and mean Karnofsky score was 20.For the first 24 h,5 of the patients experienced a subfebrile state,accompanied by mild headaches due to intrathecally administration and muscle pain because of intramuscularly administration.Neurological and functional examinations,laboratory tests,electroencephalography,and magnetic resonance imaging were performed to assess safety of treatment.Mean FIM score increased by 20.88±3.31 in the first month(P=0.027)and by 31.38±14.69 in 12 mo(P=0.012).The rate of patients with an FIM score of 126 increased from 14.58%to 16.57%in the first month and 24.90%in 12 mo.CONCLUSION Multiple triple-route Wharton’s jelly-derived MSC administrations were found to be safe for HIE patients,indicating neurological and functional improvement.Based on the findings obtained here,further randomized and placebo research could be performed. | Serdar Kabataş ErdinçCivelek Necati Kaplan Eyüp Can Savrunlu Gülseli Berivan Sezen Mourat Chasan Halil Can Ali Genç Yener Akyuva Osman Boyalı Furkan Diren Erdal Karaoz | 2021 | World Journal of Experimental Medicine2021，11，2： | 2 |
| 2 | Cardiac calcification in adult hemodialysis patients, a link between end-stage renal disease and cardiovascular disease? 显示文摘 | Raggi P Boulay A Chasan Taber S | 2002 | J Am Coll Cardiol2002，39，4： | 1 |
| 3 | The history of injectable silicone fluids for soft-tissue augmentation 显示文摘 | Chasan PE | 2007 | Plast Reconstr Surg2007，120，7： | 1 |
| 4 | Management of cutaneous manifestations of extensive purpura fulminans in a bum unit 显示文摘 | Chasan PE Hansbrough JF Cooper ML | 1992 | J Burn Care Rehabil1992，13，4： | 1 |
| 5 | Coordination complexes of the N-oxides of aromatic diimines and diazines显示文摘 | Speca A N Chasan D E | 1976 | Coord Chem Rev1976，20，： | 1 |
| 6 | Cardiac calcification a- dult hemodialysis patients A link between end stage renal disease and cardiovascular disease显示文摘 | Raggi P Boulay A Chasan S | 2002 | J Am Coll Cardio2002，39，4： | 1 |
| 7 | The history of injectable silicone fluids for soft-tissue augmentation 显示文摘 | Chasan PE | 2007 | Plast Reonstr Surg2007，120，7： | 1 |
| 8 | Frontiers in fertilization显示文摘 | Chasan R | 1992 | Plant cell1992，，4： | 1 |
| 9 | Presacral donor site for lip augmentation 显示文摘 | Chasan PE Rahban SR | 2000 | Aesthetic Plast Surg2000，24，1： | 1 |
| 10 | Actomyosin II interaction modulates cell cortex stability显示文摘 | Goldmann W H Cantiello H F Chasan B | 2005 | Cell Biology International2005，29，3： | 1 |
| 11 | Management and prognostic significance of hypercalcemia in renal cell carcinoma显示文摘 | Chasan SA Pothel LR Huben RP | | 0，，： | 1 |
| 12 | Mannose receptor polyubiquitization regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation显示文摘 | Zehner M Chasan A I Schuette V | | 0，，： | 1 |
| 13 | Mannese receiCax polyubiquitinafion regulztes endosrnal recruitment of p97 and cytoselic antigen translocation for cross-presentation显示文摘 | Zehner M Chasan A I Schuette V | 2011 | Proc Natl Acad Sci U S A2011，108，24： | 1 |
| 14 | A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women显示文摘 | Chasan TL Willett WC Seddon JM | | 0，，： | 1 |
| 15 | The multimeric structure of polycystin-2(TRPP2):structural-functional correlates of homo-and hetero-multimers with TRPC1显示文摘 | Zhang P Luo Y Chasan B | 2009 | Hum Mol Genet2009，18，： | 1 |
| 16 | The history of injectable silicone fluids for soft-tissue augmentation显示文摘 | Chasan PE | 2007 | Plast Reconstr Surg2007，120，7： | 1 |
| 17 | A prospectivecohort study of modifiable risk factors for gestational diabetes amongHispanic women: design and baseline characteristics 显示文摘 | Chasan -Taber L Fortner RT Gollenberg A | 2010 | J WomensHealth (Larchmt)2010，19，1： | 1 |
| 18 | Lifestyle interventions to reduce risk of dia- betes among women with prior gestational diabetes mellitus 显示文摘 | Chasan Taber L | 2015 | Best Pract Res Clin Obstet Gynaecol2015，29，1： | 1 |
| 19 | Ashless antioxidants, copper deactivators and corrosion inhibitors :their use in lu- bricating oils显示文摘 | Hamblin P C Kristen U Chasan D | 1990 | Lubrication Science1990，，24： | 1 |
| 20 | Quadripolar left ventricular Lead in a patient with CRT-D does not overcome phrenic nerve stimulation 显示文摘 | Parahuleva M S Chasan R Soydan N | 2011 | Clin Med Insights Cardiol2011，5，： | 1 |
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