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    题名 作者 年代 出处 被引量
1非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系显示文摘尽管非维生素K拮抗口服抗凝剂(non-vitamin K antagonist oral anticoagulants, NOACs)越来越多地应用于预防血栓栓塞性疾病,但关于NOACs相关性脑出血的数据仍然有限。刘青 叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH Reeves MJ Hernandez AF Bhatt DL Peterson ED Fonarow GC 2018中华高血压杂志2018,26,2:16
2星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊 2019神经损伤与功能重建2019,14,6:2
3Subeortieal ischaemie vascular dementia 显示文摘Roman GC Erkinjuntti T Wallin A 2002Lancet Neurol2002,1,:1
4A neutron-diffraction study of the effect of hydration on stratum comeum structure 显示文摘CHARALAMBOPOULOU GC STER1OTIS TA HAUSS T 2002Appl Phys A-Mater2002,74,1:1
5Radiation protection during percutaneous nephrolithotomy:a new urologic surgery radiation shield 显示文摘YANG RM MORGAN T BELLMAN GC 2002J Endourol2002,16,10:1
6Total hip arthroplasty follow- ing failed intemal fixation of hip fractures 显示文摘Mehlhoff T Landon GC Tullos HS 1991Clin orthop1991,,269:1
7Subcortical ischaemic vascular dementia显示文摘Romtin GC Erkinjuutti T Wallin A 2002Lancet Neurol2002,1,7:1
8Haplotypes of IL-10 promoter vari- ants are associated with susceptibility to severe malarial anemia and func- tional changes in IL-10 production显示文摘Ouma C Davenport GC Were T 2008Hum Genet2008,124,5:1
9Muscle-specific signaling mechanism that links actin dynamics to serum response factor显示文摘Kuwahara K Barrientos T Pipes GC 2005Mol Cell Biol2005,25,8:1
10Identification of carcinoma cells in peripheral blood samples of patients with advanced breast carcinoma using RT-PCR amplification of CK7 and MUC1显示文摘Felton T Harris GC Pinder SE 2004Breast2004,1,3:1
11The superficial palmar arch and median artery as an example of misleading results due to a small number of investigated specimens or the use of different classifications显示文摘Feigl GC Petrac M Pixner T 2012Ann Anat2012,194,4:1
12Subcortical ischaemic vascular dementia显示文摘Roman GC Erkinjunti T Wallin A 2002Lancet Neurol2002,1,7:1
13Cholesterol and the risk of renal dysfunction in apparently healthy men显示文摘Schaeffner ES Kurth T Curhan GC 2003J Am Soc Nephrol2003,14,8:1
14Inhibition of matrix metalloproteinase-9 activity by doxyeycline ameliorates RANK ligand-indueed osteoclast differentiation in vitro and in vivo显示文摘Franeo GC Kajiya M Nakanishi T 2011Exp Cell Res2011,317,10:1
15Vasculardementia:diagnostic criteria for research studies显示文摘Roman GC Tatemichi TK Erkinuntt T 1997Stroke1997,28,:1
16Subcortical ischaemic vascular dementia显示文摘 Erkinjuntti T Wallin A 2002LancetNeurol2002,1,:1
17Vascular dementia:diagnostic criteria for research studies:report of the NINCDS-AIREN Iternational Workshop显示文摘Roman GC Tatemichi TK Erkijuntti T 1993Neurology1993,43,:1
18Subcortical ischaemic vascular dementia显示文摘Roman GC Erkinjuntti T Wallin A 2002Lancet Neurol2002,1,:1
19Cholesterol and the risk of renal dysfunction in apparently healthy men 显示文摘Schaeffner ES Kurth T Curhan GC 2003J Am Soc Nephrol2003,14,8:1
20Vascular dementia:diagonostic criteria for research studies:report of the NINDS-AIREN International workshop显示文摘Roman GC Tatemichi TK Erkinjunhi T 0,,02:1
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