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| 1 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 2 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 3 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 4 | Microscopic colitis: A retrospective study of clinical presentation in 53 patients显示文摘AIM: To evaluate the relationship between symptoms and microscopic colitis (MC) subtypes: to test whether collagenous colitis (CC) and/or lymphocytic colitis (LC)might be related to both constipation and diarrhea.METHODS: A cohort of patients with independently confirmed typical histopathological changes was investigated. Fifty-three patients with histologically proved MC (46 with CC, 7 with LC) were included. The existence of diarrhea or constipation and the co-existence of autoimmune diseases were also investigated and all data were retrospectively analyzed.RESULTS: Twenty-three (43.39%) of MC patients had chronic constipation (20 in CC, 3 in LC patients). Twentyfour(45.28%) of MC patients had autoimmune disease and the diagnosis of autoimmune disease was always prior to MC. Sjogren's syndrome was associated only with the constipation subgroup.CONCLUSION: The Janus face of MC resembles the subgroups of irritable bowel syndrome. The co-existence of autoimmune diseases and MC is confirmed in both the constipation and diarrhea subgroups. | Zsolt Barta Gabriella Mekkel István Csíp(o|') László Tóth Szabolcs Szakáll Gábor G.Szabó Gyula Bakó Gyula Szegedi Margit Zeher | 2005 | World Journal of Gastroenterology2005，11，9： | 3 |
| 5 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 6 | Overexprcssion of tumor necrosis factor- alpha activites both anti and proapoptosis pathways in the myocardium 显示文摘 | Kubota T Miyagishima M Frye CS | 2001 | J Mol Cell Cardiol2001，33，7： | 2 |
| 7 | Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline显示文摘 | Kidd T Russell C Goodman CS | 1998 | Neuron1998，20，1： | 1 |
| 8 | Profound systemic hypothermic inhabits the release of neurotransmitter amino acids in spinal cord ischemia显示文摘 | Rokkos MD Cronin CS Nitta T | 1995 | J Thorac Cardiovasc Surg1995，110，： | 1 |
| 9 | IL-12 and viral infection显示文摘 | Komastu T Ireland DD Reiss CS | 1998 | Cytokine Growth Factor Rev1998，9，： | 1 |
| 10 | A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro显示文摘 | Inoue I Nakajima T Williams CS | 1997 | J Clin Invest1997，99，： | 1 |
| 11 | Alkaloids from Heimiasalicifolia显示文摘 | Rumalla CS Jadhav AN Smillie T | 2008 | Phytochemistry2008，69，8： | 1 |
| 12 | The pathways and molecular mechanisms regulating Nrf2 activation inresponse to chemical stress显示文摘 | Nguyen T Yang CS Pickett CB | 2004 | Free Radie Biol Med2004，37，4： | 1 |
| 13 | Hydrogen inhalation ameliorates ventilator-induced lung injury 显示文摘 | Huang CS Kawamura T Lee S | 2010 | Crit Care2010，14，： | 1 |
| 14 | Evaluation of bchavioural and antioxidant activity of Cytisus scoparius Link in rats exposed to chronic unpredictable mild stress显示文摘 | Nirmal J Babu CS Harisudhan T | | 0，，： | 1 |
| 15 | Responsiweness to reduced dosage of rituximab in Chinese patients with neuromyelitis optica 显示文摘 | Yang CS Yang L Li T | 2013 | Neurology2013，81，8： | 1 |
| 16 | Nonextraction treatment of a Class II deepbite malocclusion with severe mandibular crowding:visualized treatment objectives for selecting treatment options显示文摘 | Asakawa S Al-Musaallam T Handelman CS | 2008 | Am J Orthod Dentofacial Orthop2008，133，2： | 1 |
| 17 | Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocytc plasma membranes in rat brain and spinal cord显示文摘 | Rash JE Yasumura T Hudson CS | 1998 | Proe Natl Acad Sci USA1998，95，11： | 1 |
| 18 | Overexpression of tumor necrosis factor - alpha activates both anti - and pro - apoptotic pathways in the myocardium 显示文摘 | Kubota T Miyagishima M Frye CS | 2001 | J Mol Cell Cardiol2001，33，7： | 1 |
| 19 | Hydrogen inhalation re- duced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activatlon显示文摘 | Huang CS Kawamura T Peng X | 2011 | Bio- ehem Biophys Res Commun2011，408，2： | 1 |
| 20 | Circulating adipo-neetin levels are associated with better glyeernie control, more favorable liquid profile, and reduced inflammation in women with type 2 diabetes显示文摘 | Mantzoros CS Li T Mansn JE | 2005 | Clin Eedocrinol Metab2005，90，： | 1 |
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