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| 1 | 结构改革与中国工业增长显示文摘1978年以来,中国工业在持续的结构改革中经历了强劲的增长和生产率水平的不断提高。本文估算了工业分行业随机前沿生产函数,发现1992年后,TFP增长超过了要素投入增长,但是TFP对工业增长的贡献在2001年后出现了下降。进一步对TFP增长分解后发现,由工业结构改革引致的行业间要素重置显然对改革开放期间中国工业生产率的提高乃至工业增长起到了实际推动作用,即结构红利是显著存在的,而2001年后要素配置效率的下降也成为同期TFP增长贡献份额下降的主要原因。因素回归分析显示,中国要素市场的改革和工业行业的结构调整主导了要素配置效率变化的总体走势,并造成了不同行业要素配置效率的显著差异。 | 张军 陈诗一 Gary H. Jefferson | 2009 | 经济研究2009，44，7： | 305 |
| 2 | 基于Pareto熵的多目标粒子群优化算法显示文摘粒子群优化算法因形式简洁、收敛快速和参数调节机制灵活等优点,同时一次运行可得到多个解,且能逼近非凸或不连续的Pareto最优前端,因而被认为是求解多目标优化问题最具潜力的方法之一.但当粒子群优化算法从单目标问题扩展到多目标问题时,Pareto最优解集的存储与维护、全局和个体最优解的选择以及开发与开采的平衡等问题亦随之出现.通过目标空间变换方法,采用Pareto前端在被称为平行格坐标系统的新目标空间中的分布熵及差熵评估种群的多样性及进化状态,并以此为反馈信息来设计进化策略,使得算法能够兼顾近似Pareto前端的收敛性和多样性.同时,引入格占优和格距离密度的概念来评估Pareto最优解的个体环境适应度,以此建立外部档案更新方法和全局最优解选择机制,最终形成了基于Pareto熵的多目标粒子群优化算法.实验结果表明:在IGD性能指标上,与另外8种对等算法相比,该算法在由ZDT和DTLZ系列组成的12个多目标测试问题集中表现出了显著的性能优势. | 胡旺 Gary G. YEN 张鑫 | 2014 | 软件学报2014，25，5： | 134 |
| 3 | 未破裂颅内动脉瘤患者管理指南美国心脏协会/美国卒中协会针对医疗专业人员的指南显示文摘目的这份更新版指南旨在为未破裂颅内动脉瘤患者的管理提供全面的循证建议。方法写作组采用系统文献回顾(1977年1月至2014年6月),参考同期已发表的循证指南、个人文件和专家意见来总结现有的证据,指出现有知识的差距;如果合适,则根据美国心脏协会( American Heart Association, AHA)标准做出推荐。本指南经过了包括卒中委员会领导层以及AHA科学声明监督委员会在内的广泛同行评议,然后由AHA科学咨询和协调委员会审批通过。结果本指南对未破裂颅内动脉瘤患者的医疗诊治提出了循证建议,涉及临床表现、自然史、流行病学、危险因素、筛查、诊断、影像学以及手术和血管内治疗的转归。 | B. Gregory Thompson Robert D. Brown Sepideh Amin-Hanjani Joseph P. Broderick Kevin M. Cockroft E. Sander Connolly Gary R. Duckwiler Catherine C. Harris Virginia J. Howard S. Claiborne (Clay) Johnston Philip M. Meyers Andrew Molyneux Christopher S. Ogilvy Andrew J. Ringer James Torner 肖国栋 徐加平 石际俊 尤寿江 张霞 刘慧慧 曹勇军 | 2015 | 国际脑血管病杂志2015，23，8： | 127 |
| 4 | Influence of the Atlantic Multidecadal Oscillation on the Winter Climate of East China显示文摘大西洋 Multidecadal 摆动(AMO ) ,诺思大西洋海面温度(SST ) 的多十的变化,与 65 80 年和 0.4 ° C 的一个振幅的一个时期展出摆动。观察合成分析表明温暖的阶段 AMO 在华东被连接到更温暖的冬季,与在这个区域的北方的提高的降水和在南方的减少的降水,在多十的时间规模上。模式在冷阶段 AMO 期间被颠倒。当一强迫华东的多十的冬季气候被调查大气的反应在大气的总环流大气环流模型(AGCM ) 的一个大整体温暖 AMO SST 异例探索, AMO 是否行动,试验。从三 AGCM 的结果是一致的并且建议 AMO 温暖在华东赞成更温暖的冬季。这影响通过在从中间的纬度诺思大西洋延长到中间的纬度欧亚大陆的半球宽的领域导致否定表面气压异例被认识到。这些否定表面异例赞成高变弱蒙古的寒冷,并且因此导致更弱的东方亚洲冬季季风。 | 李双林 Gary T.BATES | 2007 | Advances in Atmospheric Sciences2007，24，1： | 72 |
| 5 | 美国国立神经疾病和卒中研究所-加拿大卒中网血管性认知障碍统一标准显示文摘背景和目的:1/3的个体会罹患卒中和(或)痴呆,而且,除卒中或痴呆外,2倍于此数的人会出现认知障碍。常用的卒中量表并不能评价认知功能,而痴呆的诊断标准则集中在认知障碍的晚期阶段,且在很大程度上偏向Alzheimer病(AD)的诊断。尚缺乏普遍公认的标准用于识别和描述存在认知障碍的个体,尤其是在早期阶段,而且特别是与血管因素有关的认知障碍或血管性认知障碍。方法:美国国立神经疾病和卒中研究所(MINDS)与加拿大卒中网(CSN)召集临床诊断、流行病学、神经心理学、脑影像学、神经病理学、试验模型、生物标记物、遗传学和临床试验方面的研究人员,为血管性认知障碍的描述和研究推荐一些最低限度的常用的临床和研究标准。结果:将这些讨论的结果发表于此。结论:一个统一标准的制定代表着使用、确认和改进过程中的第一步。使用相同的标准将有助于在认知障碍的早期阶段识别患者,使不同的研究具有可比性,并且通过整合知识来加速研究进展的步伐。 | Vladimir Hachinski Costantino Iadecola Ron C.Petersen Monique M.Breteler David L.Nyenhuis Sandra E.Black William J.Powers Charles DeCarli Jose G.Merino Raj N.Kalaria Harry V.Vinters David M.Holtzman Gary A.Rosenberg Martin Dichgans John R.Marler Gabrielle G.Leblanc 李焰生(译) 俞羚(译) 高枚春(译) 张静芳(译) 熊昕丽(译) 邹静(译) 林岩(译) 潘元美(译) | 2007 | 国际脑血管病杂志2007，15，1： | 63 |
| 6 | 扇形喷头雾滴粒径分布风洞试验显示文摘利用开路式风洞系统和Sympatec激光粒度仪测试了参考喷头的雾谱尺寸以此作为喷头雾谱等级的依据。对扇形雾喷头在不同压力、风速、喷头与激光粒度仪距离情况下的雾滴粒径、数量和范围进行了试验。试验结果表明,压力、风速、喷头与激光粒度仪之间距离的增大,都导致扇形雾喷头的雾滴体积中径变小,尺寸小于150μm的雾滴占全部雾滴体积的百分比变大,增加了农药脱靶飘移的可能性,同时压力和风速的增大都导致部分喷头的雾谱等级降低。为了保证激光粒度仪对雾滴粒径测试结果的可靠性,可以使用风洞试验和调整喷头与激光粒度仪的距离,来减小因细小雾滴通过激光束过程中速度迅速衰减而对测量结果带来的影响。 | 张慧春 Dorr Gary 郑加强 周宏平 | 2012 | 农业机械学报2012，43，6： | 67 |
| 7 | 肛裂临床诊治指南(第三次修订)显示文摘“美国结直肠外科医师协会(American Societyof ColonandRectal Surgeons.ASCRS)”(协会)致力于推进结直肠和肛门疾病的相关理论以及预防和诊疗水平的提高,给患者提供优质的医疗服务。“标准委员会”由协会中在结直肠外科方面有显著专长的成员组成。该委员会的建立是为了引领国际结直肠和肛门疾病诊治的发展,以建立具有循证医学证据的临床诊疗指南。指南是涵盖性的,非指令性的,目的是为临床决策提供信息,而非具体的治疗方法。指南适用于所有相关的医护人员以及希望得到相应指南中疾病的相关诊治信息的患者。 | Farshid Araghizadeh ~ Robin Boushey Sridhar Chalasani George Chang Robert Cima Gary Dunn Daniel Feingold Philip Fleshner Daniel Geisler Jill Genua Sharon Gregorcyk Daniel Herzig Andreas Kaiser Ravin Kumar David Larson Steven Mills John Monson P. Terry Phang Feza Remzi David Rivadeneira Howard Ross Peter Senatore Elin Sigurdson Thomas Stahl Scott Steele Scott Strong Charles Tement Judith Trudel Madhulika Varnna Martin Weiser 丁义江(译) 皇甫少华(译) 丁曙晴(译) | 2013 | 中华胃肠外科杂志2013，16，7： | 70 |
| 8 | 基于计算试验设计与代理模型的飞行器近似优化策略探讨显示文摘现代飞行器设计优化中广泛应用高精度分析模型以提高设计可信度与综合性能,但是也带来了计算复杂性问题。为了有效缓解计算耗时的问题,基于计算试验设计与代理模型的飞行器近似优化策略成为研究热点。近似优化策略通过构造合理的近似模型引导优化过程快速收敛到最优解,从而达到降低计算成本,缩短设计周期的目的。根据广泛的文献调研,对飞行器近似优化策略的发展现状进行详细探讨。给出近似优化策略的定义、求解流程、特点以及关键技术。对计算试验设计方法、代理模型方法、精度校验与代理模型选择方法等技术进行综述。围绕静态与自适应两类近似优化策略,重点讨论典型的代理模型管理与更新策略与收敛准则。针对飞行器多学科设计优化问题,探讨近似优化策略与分解策略在求解效率与收敛性方面的技术特点。通过数值算例对各项关键技术的特点进行较详尽的对比分析与总结,并依托飞行器设计优化工程实例对近似优化策略的综合性能进行探讨,指出不同近似优化策略的适用范围。研究结果表明,飞行器近似优化策略在优化效率、全局收敛性以及鲁棒性等方面体现出较显著的优势,具有良好的工程应用前景。指出飞行器近似优化策略的未来研究方向。 | 龙腾 刘建 WANG G Gary 刘莉 史人赫 郭晓松 | 2016 | 机械工程学报2016，52，14： | 69 |
| 9 | Morinda citrifolia (Noni): A literature review and recent advances in Noni research^1显示文摘Morinda citrifolia L(Noni) has been used in folk remedies by Polynesians for over 2000 years,and is reported to have a broad range of therapeutic effects,including antibacterial,antiviral,antifungal,antitumor,antihelmin,analgesic,hypotensive,anti-inflammatory,and immune enhancing effects.In order to reveal the nutritional and medicinal value of the Noni plant,and to summarize scientific evidence that supports the Polynesians' claim,a literature review and recent advances in Noni research is given below. | Brett J WEST CJarakae JENSEN Diane NOWICKI SU Chen Afa K PALU Gary ANDERSON | 2002 | Acta Pharmacologica Sinica2002，23，12： | 80 |
| 10 | Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of liver-related morbidity and mortality. It can develop secondary to numerous causes but a great majority of NAFLD cases occur in patients who are obese or present with other components of metabolic syndrome (hypertension, dyslipidemia, diabetes). This is called primary NAFLD and insulin resistance plays a key role in its pathogenesis. Obesity is characterized by expanded adipose tissue, which is under a state of chronic inflammation. This disturbs the normal storage and endocrine functions of adipose tissue. In obesity, the secretome (adipokines, cytokines, free fatty acids and other lipid moieties) of fatty tissue is amplified, which through its autocrine, paracrine actions in fat tissue and systemic effects especially in the liver leads to an altered metabolic state with insulin resistance (IR). IR leads to hyperglycemia and reactive hyperinsulinemia, which stimulates lipid-accumulating processes and impairs hepatic lipid metabolism. IR enhances free fatty acid delivery to liver from the adipose tissue storage due to uninhibited lipolysis. These changes result in hepatic abnormal fat accumulation, which may initiate the hepatic IR and further aggravate the altered metabolic state of whole body. Hepatic steatosis can also be explained by the fact that there is enhanced dietary fat delivery and physical inactivity. IR and NAFLD are also seen in various lipodystrophic states in contrary to popular belief that these problems only occur due to excessive adiposity in obesity. Hence, altered physiology of adipose tissue is central to development of IR, metabolic syndrome and NAFLD. | Kamran Qureshi Gary A Abrams | 2007 | World Journal of Gastroenterology2007，13，26： | 52 |
| 11 | 血管性认知损害诊断的进一步规范化:血管性认知损害分类共识研究组指南显示文摘引言血管性认知损害(vascular cognitive impairment,VCI)诊断共识的缺乏(体现为多种不同评估方案的使用),妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究(Vascular Impairment of Cognition Classification Consensus Study,VICCCS),旨在就VCI的诊断原则(VICCCS-1)和诊断方案(VICCCS-2)达成一致意见.本文提供了VICCCS-2的相关内容.方法使用VICCCS-1达成的原则和已发表的诊断指南作为在线德尔菲(Delphi)调查的参考基点,以期对VCI的临床诊断达成共识.结果共进行了6轮调查,每轮有65~79名专家参与,他们就VICCCS修订的轻度和重度VCI的诊断指南达成共识,并肯定了美国国立神经疾病与卒中研究所-加拿大卒中网(National Institute of Neurological Disorders and Stroke–Canadian Stroke Network,NINDS-CSN)发布的神经心理学评估方案和对影像学检查的推荐意见.讨论VICCCS-2建议规范化应用NINDS-CSN推荐的神经心理学和影像学评估方案诊断VCI,以促进研究协作. | Olivia A. Skrobot Sandra E. Black Christopher Chen Charles DeCarli Timo Erkinjuntti Gary A. Ford Rajesh N. Kalaria John O'Brien Leonardo Pantoni Florence Pasquier Gustavo C. Roman Anders Wallin Perminder Sachdev Ingmar Skoog the VICCCS group Yoav Ben-Shlomo Anthony P. Passmore Seth Love Patrick G. Kehoe 朱婷珂 徐俊 | 2018 | 国际脑血管病杂志2018，26，4： | 58 |
| 12 | An Exploratory Analysis of Vegetation Strategies to Reduce Shallow Landslide Activity on Loess Hillslopes, Northeast Qinghai-Tibet Plateau, China显示文摘Heavy summer rainfall induces significant soil erosion and shallow landslide activity on the loess hillslopes of the Xining Basin at the northeast margin of the Qinghai-Tibet Plateau. This study examines the mechanical effects of five native shrubs that can be used to reduce shallow landslide activity. We measured single root tensile resistance and shear resistance, root anatomical structure and direct shear and triaxial shear for soil without roots and five root- soil composite systems. Results show that Atriplex canescens (Pursh) Nutt. possessed the strongest roots, followed by Caragana korshinskii Kom., Zygophyllum xanthoxylon (Bunge) Maxim., Nitraria tangutorum Bobr. and Lycium chinense Mill. Single root strength and shear resistance relationships with root diameter are characterized by power or exponential relations, consistent with the Mohr- Coulomb law. Root mechanical strength reflects their anatomical structure, especially the percentage of phloem and xylem cells, and the degree and speed of periderm lignifications. The cohesion force of root- soil composite systems is notably higher than that of soil without roots, with increasing amplitudes of cohesion force for A. canescens, C. korshinskii, Z. xanthoxylon, N. tangutorum and L. chinense of 75.9%, 75.1%, 36.2%, 24.6% and 17.0 % respectively. When subjected to shear forces, the soil without root samples show much greater lateral deformation thanthe root-soil composite systems, reflecting the restraining effects of roots. Findings from this paper indicate that efforts to reduce shallow landslides in this region by enhancing root reinforcement will be achieved most effectively using A. canescens and C. korshinskii. | HU Xia-song BRIERLEY Gary ZHU Hai-li LI Guo-rong FU Jiang-tao MAO Xiao-qing YU Qin-qin QIAO Na | 2013 | Journal of Mountain Science2013，10，4： | 41 |
| 13 | 24个中外猪种(群)的AFLP多态性及其群体遗传关系显示文摘利用 12对AFLP引物组合检测了 19个中国地方猪种 (群 )、1个培育猪种和 4个欧美引进猪种混合基因组DNA的遗传变异 ,根据AFLP分析结果计算了 2 4个猪种 (群 )间的遗传相似系数 ,据此构建了UPGMA聚类关系图。结果表明 ,AFLP标记有着很高的多态检测效率 (Ai) ,平均每个引物组合检测到 17.3个多态标记 ,非常适合于猪种(群 )遗传多样性分析和品种鉴定 ;中国地方猪种与欧美引进猪种间的遗传分化十分明显 ,两类猪群间的亲缘关系较远 ;南昌白猪与大白猪、铅山黑猪与玉山黑猪有着极近的亲缘关系 ,分别与其育成历史、地理分布和RAPD分析结果相一致。另外还对部分猪种 (群 )的聚类分析结果与其形态学。 | 任军 黄路生 艾华水 Gary Evens 高军 陈克飞 丁能水 邓素华 | 2002 | Acta Genetica Sinica2002，29，9： | 41 |
| 14 | 山东济南长清月庄遗址植物遗存的初步分析显示文摘2003年3-6月,山东长清月庄遗址发掘期间,采集了一批以后李文化为主的土壤样品进行浮选。我们曾简单报道过月庄遗址H124浮选出的后李文化时期炭化稻,这是目前中国北方见到最早的稻谷遗存之一。本文将详细报道全部浮选结果,以期认识月庄遗址先民与植物之间的关系,对于理解全新世早期人类与植物的互动关系、植物的利用以及黄河流域早期食物生产等方面有重要意义。 | Gary W.Crawford | 2013 | 江汉考古2013，，2： | 40 |
| 15 | 喷雾飘移的风洞试验和回归模型显示文摘为了掌握农药喷雾飘移的规律,从而为控制农药飘移到非靶标区域提供理论支持和技术依据,论文测试了由风洞地面向上0.1-0.5 m放置的5根间隔0.1 m以及水平方向距地面0.1 m高从2-6 m放置的5根间隔1 m的聚乙烯收集线所收集的含荧光示踪剂的雾滴,由荧光分析仪测定了收集线上的荧光剂含量,分析了不同位置处的雾滴沉积和飘移。针对Tee Jet公司的XR 11002延长范围扇形喷头、AIXR 11002气吸扇形喷头、TT 11002广角扇形喷头和TTI 11002涡流气吸型喷头在不同位置处的雾滴飘移试验、得到不同类型的喷头在不同风速和药剂时的雾滴飘移结果。结果显示,随着垂直高度和水平距离的增加,雾滴的沉积减少。风速增大时,垂直高度0.1-0.5 m和水平距离2-6 m的雾滴飘移都会更加严重。气吸扇形和涡流气吸型结构的喷头能产生更大尺寸雾滴,减少飘移量。采用SPSS软件建立了包含采样距离、风速、喷头类型和药剂类型在内的多变量非线性雾滴飘移特性模型,经检验,该回归模型的拟合度在0.847以上,此模型有助于降低喷雾飘移的风险,为气象条件的选择、雾滴沉积区域的预测、缓冲隔离区的确定、防飘施药技术的研究和喷施药剂药械的配套选用提供技术指导。 | 张慧春 Gary Dorr 郑加强 周宏平 于君 | 2015 | 农业工程学报2015，31，3： | 29 |
| 16 | The effect of the substrate on the Raman and photoluminescence emission of single-layer MoS2显示文摘 | Michele Buscema Gary A. Steele Herre S. J. van der Zant &ndres Castellanos-Gomez | 2014 | Nano Research2014，7，4： | 28 |
| 17 | 农用喷头雾化粒径测试方法比较及分布函数拟合显示文摘农药雾滴粒径是影响农药在靶标上的沉积量和分布均匀性的主要因素,测试方法和仪器很多。该文使用激光粒子图像分析测试系统(particle/droplet image analysis,PDIA)、Sympatec HELOS Vario激光衍射粒度分析仪和Spraytec实时喷雾粒度分析仪3种常用的雾滴粒径分析仪对ST喷头进行雾滴粒径测试,结果表明3种仪器测得的雾滴体积中径(VMD,volume median diameter)绝对结果有差异,但是与已有的喷头雾滴细度界限值相比,该文所用的不同仪器测量结果对相同喷头的定级相同。鉴于此,选用Spraytec对Lechler公司生产的IDK、TR和ST 3种类型、2个国标流量代号(02和03)的6种型号喷头在喷雾扇面内的VMD进行测试,基于最小二乘法对测试结果进一步分析拟合,得到VMD在喷雾扇面内分布规律的函数形式。回归拟合函数以位置信息(喷雾高度,水平位置)为自变量、VMD为因变量,经回归效果检验可知各函数F统计量皆大于其F临界值(α=0.05),且相关指数都大于0.8,表明该文中所得的拟合函数可以较准确地描述雾滴粒径分布规律,并较精确地预测出扇面中非测试点的雾滴粒径。这些拟合函数为进一步研究喷杆各喷头喷雾扇面叠合后的雾滴粒径分布提供了基础。 | 王双双 何雄奎 宋坚利 张录达 Gary J. Dorr Andreas Herbst | 2014 | 农业工程学报2014，30，20： | 27 |
| 18 | 食物过敏的定义、流行性、诊断及治疗显示文摘食物过敏是异质性群体相关疾病,会通过一种或多种方式对多个器官造成影响。其反应的严重程度可从轻度的局部反应到全身性的过敏反应。从机制上来看,食物过敏是Th2细胞驱动的免疫紊乱疾病,食物特异性IgE是这种速发型不良反应的基础。过敏的部位和症状并不一定相同。食物过敏常会与自身免疫性(如乳糜泻)和非免疫性(如乳糖不耐受)的其他食物不良反应相混淆。为了正确诊断食物过敏,需要详细了解患者病史,检测特异性IgE,并进行经口激发试验来确诊。一些辅助因素(如运动、药物和酒精)有助于诱发食物过敏,会进一步增加诊断的复杂性。以食物提取物为基础的诊断试验并不能反映症状的严重程度,而检测单个食物致敏原IgE的新一代分子诊断技术,则能够为临床医生和患者提供可靠的症状严重程度依据。分子诊断还有助于确定食物过敏是直接源于对食物的暴露还是间接源于花粉过敏(交叉反应)。流行病学调查表明,桃过敏在欧洲主要是源于对桃的食用,而在中国则是源于对艾蒿花粉的初级致敏。但这两种情况都是由来自同一家族的致敏原分子介导的。流行病学调查深入揭示了食物过敏的病因、流行性及其所包含的风险因素,为预防食物过敏提供了循证策略。过去的十年中,食物过敏在发达国家盛行。经济发展和城市化进程都被认为会导致食物过敏流行性的增加,而且饮食习惯不同,过敏的食物也不同。目前,分子变态反应学和生物技术正在开发安全的免疫治疗方法,有望能够减轻日益加重的食物过敏负担。一种使用低致敏性突变重组分子的免疫疗法已经开始进行第一阶段临床试验的评估。食物致敏原名单的不断完善为转基因食品致敏性的评估提供了坚实基础。 | Ronald van Ree Lars K. Poulsen Gary WK Wong Barbara K. Ballmer-Weber 高中山 贾旭东 | 2015 | 中华预防医学杂志2015，49，1： | 28 |
| 19 | Current understanding of the molecular mechanisms in Parkinson's disease:Targets for potential treatments显示文摘Gradual degeneration and loss of dopaminergic neurons in the substantia nigra,pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize Parkinson’s disease(PD).In addition,half of the PD patients also exhibit frontostriatal-mediated executive dysfunction,including deficits in attention,short-term working memory,speed of mental processing,and impulsivity.The most commonly used treatments for PD are only partially or transiently effective and are available or applicable to a minority of patients.Because,these therapies neither restore the lost or degenerated dopaminergic neurons,nor prevent or delay the disease progression,the need for more effective therapeutics is critical.In this review,we provide a comprehensive overview of the current understanding of the molecular signaling pathways involved in PD,particularly within the context of how genetic and environmental factors contribute to the initiation and progression of this disease.The involvement of molecular chaperones,autophagy-lysosomal pathways,and proteasome systems in PD are also highlighted.In addition,emerging therapies,including pharmacological manipulations,surgical procedures,stem cell transplantation,gene therapy,as well as complementary,supportive and rehabilitation therapies to prevent or delay the progression of this complex disease are reviewed. | Panchanan Maiti Jayeeta Manna Gary L.Dunbar | 2017 | Translational Neurodegeneration2017，6，1： | 27 |
| 20 | Fibrinogen-like protein 2 fibroleukin expression and its correlation with disease progression in murine hepatitis virus type 3-induced fulminant hepatitis and in patients with severe viral hepatitis B显示文摘AIM: To evaluate the expression of fibrinogenlike protein 2 (fgl2) and its correlation with disease progression in both mice and patients with severe viral hepatitis.METHODS: Balb/cJ or A/J mice were infected intraperitoneally (ip) with 100 PFU of murine hepatitis virus type 3 (MHV-3), liver and serum were harvested at 24, 48, and 72 h post infection for further use. Liver tissues were obtained from 23 patients with severe acute chronic (AOC) hepatitis B and 13 patients with mild chronic hepatitis B. Fourteen patients with mild chronic hepatitis B with cirrhosis and 4 liver donors served as normal controls. In addition, peripheral blood mononuclear cells (PBMC) were isolated from 30 patients (unpaired) with severe AOC hepatitis B and 10 healthy volunteers as controls. Procoagulant activity representing functional prothrombinaseactivity in PBMC and white blood cells was also assayed. A polyclonal antibody against fgl2 was used to detect the expression of both mouse and human fgl2 protein in liver samples as well as in PBMC by immunohistochemistry staining in a separate set of studies. Alanine aminotransferase (ALT) and total bilirubin (TBil) in serum were measured to assess the severity of liver injury.RESULTS: Histological changes were found in liver sections 12-24 h post MHV-3 infection in Balb/cJ mice.In association with changes in liver histology, marked elevations in serum ALT and TBil were observed. Mouse fgl2 (mfgl2) protein was detected in the endothelium of intrahepatic veins and hepatic sinusoids within the liver 24 h after MHV-3 infection. Liver tissues from the patients with severe AOC hepatitis B had classical pathological features of acute necroinflammation. Human fgl2 (hfgl2)was detected in 21 of 23 patients (91.30%)with severe AOC hepatitis B, while only 1 of 13 patients(7.69%) with mild chronic hepatitis B and cirrhosis had hfgl2 mRNA or protein expression. Twenty-eight of thirty patients (93.33%) with severe AOC hepatitis B and 1of 10 with mild chronic hepatitis B had detectable hfgl2expression in PBMC. No hfgl2 expression was found either in the liver tissue or in the PBMC from normal donors. There was a positive correlation between hfgl2expression and the severity of the liver disease as indicated by the levels of TBil. PCA significantly increased in PBMC in patients with severe AOC hepatitis B.CONCLUSION: The molecular and cellular results reported here in both mice and patients with severe viral hepatitis suggest that virus-induced hfgl2prothrombinase/fibroleukin expression and the coagulation activity associated with the encoded fgl2protein play a pivotal role in initiating severe hepatitis.The measurement of hfgl2/fibroleukin expression in PBMC may serve as a useful marker to monitor the severity of AOC hepatitis B and a target for therapeutic intervention. | Chuan-Long Zhu Wei-Ming Yan Fan Zhu Yong-Fen Zhu Dong Xi De-Ying Tian Gary Levy Xiao-Ping Luo Qin Ning | 2005 | World Journal of Gastroenterology2005，11，44： | 26 |
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