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| 1 | Injectable melatonin-loaded carboxymethyl chitosan(CMCS)-based hydrogel accelerates wound healing by reducing inflammation and promoting angiogenesis and collagen deposition显示文摘Carboxymethyl chitosan(CMCS)-based hydrogels have antibacterial activity,and have shown the abilities of preventing wound infection,promoting cell proliferation,accelerating collagen deposition,and stimulating hyaluronic acid formation during wound healing.As a hormone produced by the pineal gland in humans and animals,melatonin promotes skin wound healing by regulating the release of inflammatory mediators and accelerating the proliferation and migration of cells,angiogenesis,and collagen deposition.However,the combined effects of CMCS and melatonin on wound healing remain unclear.Injectable CMCS-based hydrogels containing melatonin were prepared,and their healing effects were evaluated using a full-thickness cutaneous wound model in rats.Compared with the control and the hydrogel with no melatonin groups,the melatonin-loaded hydrogel significantly increased the percentage of wound closure,promoted the proliferation of granulation tissue and re-epithelialization,and accelerated collagen deposition.Additionally,the melatonin-loaded hydrogel promoted angiogenesis and vascular endothelial growth factor receptor protein expression and increased the expression of cyclooxygenase-2 and inducible nitric oxide synthase.The melatonin-loaded hydrogel also markedly increased the expression of collagen III,α-smooth muscle actin,and transforming growth factor-β1 proteins and reduced collagen I expression.These results suggest that the melatonin-loaded hydrogel promoted granulation tissue formation and accelerated wound healing by reducing inflammation and promoting angiogenesis and collagen deposition. | Kai Chen Changci Tong Jinge Yang Peifang Cong Ying Liu Xiuyun Shi Xu Liu Jun Zhang Rufei Zou Keshen Xiao Yuyang Ni Lei Xu Mingxiao Hou Hongxu Jin Yunen Liu | 2021 | Journal of Materials Science & Technology2021，，4： | 2 |
| 2 | Thermalresponseofgraphiteepoxycompositesubjectedtorapidheating显示文摘 | GriffisCA MasumuraRA ChangCI | 1981 | JCompositeMaterials1981，15，： | 1 |
| 3 | Failureanalysisofagraphite/epoxylaminatesubjectedtocombinedthermalandmechanicalloading显示文摘 | ChenJK SunCT ChangCI | 1985 | JCompositeMaterials1985，19，： | 1 |
| 4 | Multiple Solutions for a Fourth-Order Boundary Value Problem 显示文摘 | PANG Changci DONG Wei WEI Zhongli | 2006 | J Math Anal Appl2006，314，2： | 1 |
| 5 | Comparison of shoulderultrasound and MR imaging in diagnosing full -thickness rotatorcuff tears显示文摘 | ChangCY Wang SF Chiou HJ | 2002 | Clin Imaging2002，26，1： | 1 |
| 6 | The existence of two positive solutions to the fouth-order sigular boundary value problem显示文摘 | PANG Changci WEI Zhongli | 2003 | Acta Math Sinica2003，46，2： | 1 |
| 7 | Hyperspectralimageclassificationanddimensionalityreduction:anorthogonalsubspaceprojection显示文摘 | HarsanyiJC ChangCI | 1994 | IEEETransactionsonGeoscienceandRemoteSensing1994，32，77： | 1 |
| 8 | AJointBandPri- oritization and Band-Decorrelation Approach to Band Selection for Hyperspectral Image Classification显示文摘 | ChangCI DuQ SunT | | 0，，06： | 1 |
| 9 | Positive solutions of singular Caputo fractional differential equations with integral boudary conditions 显示文摘 | Wei Z1 Pang Changci Ding Youzheng | 2012 | Commun Nonlinear Sci Numer Simulat2012，，17： | 1 |
| 10 | Multiply solutions for fourth-order boundary valueproblem显示文摘 | Pang Changci Wei Dong Zhongli Wei | 2006 | Journal of Mathematics Analysis and Application2006，314，2： | 1 |
| 11 | Effectsofinoc-ulatedRhizobiumonsoybeanNandP[J]显示文摘 | CHANGCY(常从云) LUZH(卢增辉) DAISY(戴蜀珏) etal | | 中国油料0，，： | 1 |
| 12 | Nonlinear analysis iaofstress and strain in soils显示文摘 | Duncan JM ChangCY | 1970 | JSMFD:ASCE1970，96，5： | 1 |
| 13 | PERIODIC BOUNDARY VALUE PROBLEMS FOR FIRST ORDER FUNCTIONAL DIFFERENTIAL EQUATIONS显示文摘In this paper, we investigate the periodic boundary value problems for nonlinear first order functional differential equations. By establishing a new comparison result, criteria on the existence of maximal and minimal solutions are obtained. | Pang Changci Wei Zhongli | 2005 | Annals of Differential Equations2005，21，3： | 1 |
| 14 | Identification of antigen-specific residues on E2 glycoprotein of classical swine fever virus显示文摘 | CHANGCY HUANGCC LINYJ etal | 2010 | Virus Res2010，152，： | 1 |
| 15 | Multiple solutions for fourth-order boundary value problem显示文摘 | Pang Changci Dong Wei Wei Zhongli | 2006 | J Math Anal Appl2006，314，： | 1 |
| 16 | The method of lower and upper solutions for fourth order singular m-poim boundary value problems显示文摘 | WEI ZHONGLI PANG CHANGCI | 2006 | J Math Anal Appl2006，322，2： | 1 |
| 17 | Hand,foot and mouth disease in Singapore:a comparison of fatal and non-fatal cases显示文摘 | ChangCY ChanKP ShahVA | 2003 | Acta Paediatr2003，92，10： | 1 |
| 18 | Use of autologous buccal mucosa for vaginoplasty:a study of eight cases显示文摘 | Lin WC ChangCY Shen YY | | 0，，03： | 1 |
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