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| 1 | Neuroprotective effects of bovine colostrum on intracerebral hemorrhage-induced apoptotic neuronal cell death in rats显示文摘Brain cell death after intracerebral hemorrhage may be mediated in part by an apoptotic mechanism. Colostrum is the first milk produced by mammals for their young. It plays an important role in protection and development by providing various antibodies, growth factors and nutrients, and has been used for various diseases in many countries. In the present study, we investigated the anti-apoptotic effects of bovine colostrum using organotypic hippocampal slice cultures and an intracerebral hemorrhage animal model. We performed densitometric measurements of propidium iodide uptake, a step-down avoidance task, Nissl staining, and caspase-3 immunohistochemistry. The present results revealed that colostrum treatment significantly suppressed N-methyl-D-aspartic acid-induced neuronal cell death in the rat hippocampus. Moreover, colostrum treatment improved short-term memory by suppressing hemorrhage-induced apoptotic neuronal cell death and decreasing the volume of the lesion induced by intracerebral hemorrhage in the rat hippocampus. These results suggest that colostrum may have a beneficial role in recovering brain function following hemorrhagic stroke by suppressing apoptotic cell death. | Sung Eun Kim ll Gyu Ko Mal Soon Shin Chang Ju Kim Young Gwan Ko Hanjin Cho | 2012 | Neural Regeneration Research2012，7，22： | 2 |
| 2 | Targeting of peptide and protein drugs to specific sites in the oral route显示文摘 | Bai JP Chang LL Guo JH | 1995 | Crit Rev Ther Drug Carrier Syst1995，12，： | 1 |
| 3 | Carrier Densities in InAs/Ga(Al)Sb(As) Quantum Wells显示文摘 | Munekata H Esaki L Chang LL | 1987 | Journal of Vacuum Science and Technology B1987，5，3： | 1 |
| 4 | Potent and orally active angiotensin Ⅱ antagonists with equal affinity for the human AT1 and AT2 subtypes显示文摘 | Chang LL Ashton WT Flanagen KL | 1995 | J Med Chem1995，38，： | 1 |
| 5 | Effects of polyacrylic polymers on the lumenal proteolysis of peptide drugs in the colon 显示文摘 | Bai JPF Chang LL Guo JH | 1995 | J Pharm Sci1995，84，11： | 1 |
| 6 | paclitaxel-indeced apoptosis in human gastric carcinoma cell lines显示文摘 | Chang YF Li LL Wu Cw etal | 1996 | cancer1996，77，1： | 1 |
| 7 | Pathogentic role of matrix metalloproteinase and its tissue inhibitors in preterm rat lungs exposed to hyperoxia显示文摘 | Chang LW Qian LL Rong ZH | 2002 | Acta Pharmacol Sin2002，，： | 1 |
| 8 | Secreted frizzled related protein 2 (sFRP2) decreases susceptibility to UV-induced apoptosis in primary culture of canine mammary gland tumors by NF-kappaB activation or JNK suppression显示文摘 | Lee JL Chang CJ Chueh LL | 2006 | Breast Cancer Res Treat2006，100，： | 1 |
| 9 | Urinary 8- OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics 显示文摘 | WU LL CHIOU C C Chang P Y | 2004 | Clin Chim Acta2004，339，12： | 1 |
| 10 | Signalling pathway in the induction of neurite outgrowth in human mesenchymal stem cells 显示文摘 | Chu MS Chang CF Yang CC Bau YC Ho LL Hung SC | 2005 | Cell Signal2005，18，4： | 1 |
| 11 | Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death显示文摘 | Lee HH Yang LL Wang CC Hu SY Chang SF Lee YH | 2003 | Brain Res2003，986，12： | 1 |
| 12 | Protein kinase C-dependent mitochondrial translocation of proapoptotic protein Bax on activation of inducible nitric-oxide synthase in rostral ventrolateral medulla mediates cardiovascular depression during experimentalendotoxemia显示文摘 | Chan JY Chang AY Wang LL | 2007 | Mol Pharmacol2007，71，4： | 1 |
| 13 | Potency fingerprint of herbal products danshen injection for their quality evaluation 显示文摘 | Chang YX Yan DM Chen LL | 2009 | Chem Pharm Bull2009，57，6： | 1 |
| 14 | Characterisation of drug resistance gene cassettes associated with class 1 integrons in clinical isolates of Escherichia coli from Taiwan,显示文摘 | Chung CY Chang LL Chang YH | 2000 | J Med Microbiol2000，49，12： | 1 |
| 15 | Comparison of serum human epididymis protein 4 and carbohydrate antigen 125 as markers in ovarian cancer: A meta-analysis 显示文摘 | Zhen S Bian LH Chang LL | 2014 | Mol Clin 0ncol2014，2，4： | 1 |
| 16 | ACR Appropriateness Criteria nonsurgical treatment for locally advanced non-small-cell lung cancer: good performance status/definitive intent 显示文摘 | Chang JY Kestin LL Barriger RB | 2014 | Oncology2014，28，8： | 1 |
| 17 | Charaeterisation of drug resistance gene cassettes associated with class t integrons in clinieal isolates of Escherichia coli from Taiwan, ROC 显示文摘 | Chang CY Chang LL | 2000 | J Med Microbiol2000，49，12： | 1 |
| 18 | Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atheresclerosis and diabetics 显示文摘 | Wu LL Chiou CC Chang PY | 2004 | Clin Chim Acta2004，339，： | 1 |
| 19 | Protein kinase C-dependent mitochondrial translocation of proapoptotic protein Bax on activation of inducible nitric-oxide synthase in rostral ventrolateral medulla mediates cardiovascular depression during experimental endotoxemia显示文摘 | Chan JY Chang AY Wang LL | 2007 | Mol Pharmacol2007，71，4： | 1 |
| 20 | Comparison of enterovirus 71 and coxsace virus A16 clinical illness during the Taiwan enterovirus epidemic,1998显示文摘 | Chang LL Lin TY Huang YC | | 0，，12： | 1 |
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