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| 1 | Emerging radiotherapy technologies and trends in nasopharyngeal cancer显示文摘AbTechnology has always driven advances in radiotherapy treatment.In this review,we describe the main technological advances in radiotherapy over the past decades for the treatment of nasopharyngeal cancer(NPC)and highlight some of the pressing issues and challenges that remain.We aim to identify emerging trends in radiation medicine.These include advances in personalized medicine and advanced imaging modalities,standardization of planning and delineation,assessment of treatment response and adaptive re-planning,impact of particle therapy,and role of artificial intelligence or automation in clinical care.In conclusion,we expect significant improvement in the therapeutic ratio of radiotherapy treatment for NPC over the next decade. | Michelle Tseng Francis Ho Yiat Horng Leong Lea ChoungWong Ivan WK Tham Timothy Cheo Anne WM Lee | 2020 | Cancer Communications2020，40，9： | 5 |
| 2 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 3 | Lamivudine for the prevention of hepatitis B virus reactivation in hepatitis B s-antigen seropositive cancer patients undegoing cytotoxic chemotherapy显示文摘 | Yeo W Chan PK Ho WM | 2004 | JCO2004，22，5： | 1 |
| 4 | Changes inresidual volume relative to vital capacity and total lung capacityafter arthrodesis of the spine in patients who have adolescent idio-pathic scoliosis显示文摘 | Upadhyay SS Ho EK Gunawardene WM | 1993 | J Bone Joint Surg Am1993，75，1： | 1 |
| 5 | Liver resection af teririnotecan, 52 fluorouraci and folinic acid for patient swith unreseetable colorectal livermetastases : amuhieenter phase II study by the Caneer Therapeutic Research Group显示文摘 | Ho WM Ma B Mok T | 2005 | Med 0nco2005，22，3： | 1 |
| 6 | Obesity and depressive symptoms in Chinese elderly显示文摘 | Li ZB Ho SY Chan WM | 2004 | Int J Geriatr Psychiatry2004，19，1： | 1 |
| 7 | Smoking and tuber eulosis among the elderly in Hong Kong显示文摘 | Leung CC Li T Lain TH Yew WW Law WS Tam CM Chan WM Chan CK Ho KS Chang KC | 2004 | Am J Respir Crit Care Med2004，170，9： | 1 |
| 8 | The cellular and molecular biology of the inter- vertebral disc: A clinician~ primer显示文摘 | Erwin WM Hoed KE | 2014 | J Can Chiropr Assoc2014，58，3： | 1 |
| 9 | Intermittent versus continuous erlotinib with concomitant modified 'XELOX' (q3W) in first-linetreatment of metastatic colorectal cancer: correlation with serum amphiregulin and transforming growth factor alpha显示文摘 | Ma BB Chan SL Ho WM | 2013 | Cancer2013，119，23： | 1 |
| 10 | Neuroprotective Strategies after Neonatal Hypoxic Ischemic Encephalopathy显示文摘 | Dixon BJ Reis C Ho WM | 2015 | Int J Mol Sci2015，16，22： | 1 |
| 11 | Lamivudine for the prevention of hepatitis B virus reactivation in hepatitis B s- antigen seropositive cancer patients undergoing cytotoxic chemotherapy显示文摘 | YEO W CHAN PK HO WM | 2004 | J Clin Oncol2004，22，5： | 1 |
| 12 | Occlusion of hepatic blood inflow for complex central liver resections in cirrhotic patients: a randomized comparison of hemihepatic and total hepatic occlusion techniques 显示文摘 | Wu CC Yeh DC Ho WM | 2002 | Arch Surg2002，137，12： | 1 |
| 13 | Report of 2 fatal cases of adult necrotizing fasciitis and toxic shock syndrome caused by streptococcus agalactiae 显示文摘 | Tang WM Ho PL Yau WP | 2000 | Clin Infect Dis2000，31，4： | 1 |
| 14 | Optimization of headspace solid phase microextraction (HS-SPME) for gas chromatography - mass spectrometry (GC - MS) analysis of aroma compound in palm sugar (Arenga pinnata)显示文摘 | CW Ho WM Wan Aida MY Maskat | 2006 | Journal of Food Composition and Analysis2006，19，8： | 1 |
| 15 | Lamivudine for the prevention of hepatitis B virus reactivation in hepatitis B s-antigen seropositive cancer patients undergoing cytotoxic chemotherapy 显示文摘 | Yeo W Chan PK Ho WM | 2004 | J Clin 0n- col2004，22，5： | 1 |
| 16 | Bacterial translocation after cirrhoticliver resection : a clinical investigation of 181 patients 显示文摘 | Yeh DC Wu CC Ho WM | 2003 | J SurgRes2003，111，2： | 1 |
| 17 | Pneumatosis intestinalis in the adult: benign to life-threateningcauses 显示文摘 | Ho LM Paulson EK Thompson WM | 2007 | AIR Am J Roentgenol2007，188，6： | 1 |
| 18 | Prediction and limitation of hepatic tumor resection without blood transfusion in cirrhotic patients显示文摘 | Wu CC Kang SM Ho WM | 1998 | Arch Surg1998，133，9： | 1 |
| 19 | Use of lamivudine to prevent hepatitis B virus reactivation during chemotherapy in breast cancer patients 显示文摘 | Yeo W Ho WM Hui P | 2004 | Breast Cancer Res Trea2004，88，3： | 1 |
| 20 | Appraisal of concomitant splenectomy in liver resection for hepatocellular carcinoma in cirrhotic patients with hypersplenic thrombocytopenia显示文摘 | Wu CC Cheng SB Ho WM | 2004 | Surgery2004，136，3： | 1 |
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