|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | 黄酮类化合物清除对苯半醌负离子自由基研究(Ⅰ)显示文摘以对苯半醌负离子自由基为模型 ,利用ESR技术研究黄酮类化合物清除自由基的作用 ,初步获得一些构效关系。 | 林莉莎 林永成 CHAN WL | 2002 | 中山大学学报(自然科学版)2002，41，5： | 3 |
| 3 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 4 | Relationship between trichosanthin cytotoxicity and its intracellular concentration 显示文摘 | Chan WL Zheng YT Huang H | 2002 | Toxicology2002，177，23： | 1 |
| 5 | Prevalence and Clinical Characteristics of Simple RenalCyst显示文摘 | Chang CC Kuo JY Chan WL | 2007 | J Chin MedAssoe2007，70，11： | 1 |
| 6 | Minireview: tri-chosanthin-a protein with multiple pharmacologicalproperties 显示文摘 | Shaw PC Chan WL Yeung H\V | 1994 | Life Sci1994，55，4： | 1 |
| 7 | Trentment of patients with chronic hepatitis B who have failed previous antiviral treatment with pegylated interferon alphα-2a 显示文摘 | Chan HL Wong WL Chim AM | 2008 | Antivir Ther2008，13，4： | 1 |
| 8 | NEPTUNE Study: On-treatment HBsAg level analysis confirms prediction of response observed in phase 3 study of peginterferon alfa-2a in HBeAg-positive patients 显示文摘 | Gane E Jia J Han K Tanwandee T Chuang WL Marcellin P Chan HL Piratvisuth T Wat C Martins E Liaw YF | 2011 | J Hepatol2011，54，： | 1 |
| 9 | A proinflammatory role for IL-18 in rheumatoid arthritis显示文摘 | Forsev RJ Chan WL | 1999 | J Clin Invest1999，104，10： | 1 |
| 10 | Occupational stress and burnout of lawyers显示文摘 | Tsai FJ Huang WL Chan CC | 2009 | J Occup Health2009，51，5： | 1 |
| 11 | Effects of annual influenzavaccination on mortality and hospitalization in elderlypatients with ischemic heart disease:a nationwidepopulation-based study显示文摘 | Liu IF Huang CC Chan WL | 2012 | Prev Med2012，54，6： | 1 |
| 12 | Breakage of intramedullary femoral guide rod during total knee arthro- plasty: Acase report 显示文摘 | Chan WL Yen CH Wong KK | 2006 | J Orthop Surg2006，14，1： | 1 |
| 13 | Human IL - 18 recepector and ST2L are stable and selective makers for the respective type 1 and type 2 circulating lymphocytes 显示文摘 | Chan WL Pejnovie N Lee CA | 2001 | J Immunol2001，167，3： | 1 |
| 14 | Usefulness of the CHADSY score for prognostic stratification of patients with acute myocardial infarction显示文摘 | Huang SS Chen YH Chan WL | 2014 | Am J Cardiol2014，114，9： | 1 |
| 15 | Planar versus SPET imaging in the assessment of condylar growth显示文摘 | Chan WL Carolan MG Fernandes VB | | 0，，03： | 1 |
| 16 | Differential effects of glial cell line- derived neurotrophic factor and neurturin in RET/GFRalphal - expressing cells显示文摘 | Lee RH Wong WL Chan CH | 2006 | J Neurosci Res2006，83，1： | 1 |
| 17 | BMP-7 protects mesangial cells from injury by polymeric IgA显示文摘 | Chan WL Leung JC Chan LY | 2008 | Kidney Int2008，74，： | 1 |
| 18 | Expression of sperm Ca2+-activated K+ channels in Xenopus oocytes and their modulation by extracellular ATP显示文摘 | Chan HC Wu WL Sun YP | | 0，，： | 1 |
| 19 | The use of orthographic analogies in learningtoread Chinese显示文摘 | HO C S WONG WL CHAN WS | | 0，，40： | 1 |
| 20 | A proinflammatory role for IL-18 in rheumatoid arthritis显示文摘 | Gracie JA Forsey RJ Chan WL | 1999 | J Clin Invest1999，104，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员