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| 1 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 2 | Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology显示文摘 | Mohan VP Scanga CA Yu K Scott HM Tanaka KE Tsang E Tsai MM Flynn JL Chan J | 2001 | Infect Immune2001，69，3： | 1 |
| 3 | Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erkl/2, c - jun/c - los -dependent upregulation of p21, and induction of G2 cell -cycle arrest 显示文摘 | Chan QK Lam HM Ng CF | 2010 | Cell Death Differ2010，17，9： | 1 |
| 4 | Enhancement of the cytolytic effect of anti-bacterial cecropin by the microvilli of cancer cells 显示文摘 | CHAN SC HUI L CHEN HM | 1998 | Anticancer Res1998，18，6： | 1 |
| 5 | Monophasic, solitary tumoefactive demylinating lesion: neuroimaing features and neuropathologiealdiangnosis显示文摘 | Tan HM Chan LL Chuah KI | 2004 | BrJradiol2004，7，： | 1 |
| 6 | Exposed versus buried wires for fixation of lateral humeral condyle fractures in children : a comparison of safety and efficacy 显示文摘 | Chan LW Siow HM | 2011 | J Child Orthop2011，5，5： | 1 |
| 7 | p300/CBP proteins: HATs for transcriptional bridges and scaffolds显示文摘 | La Thangue NB | 2001 | J Cell Sci2001，114，13： | 1 |
| 8 | Acetylation control of the retinoblastoma tumour-suppressor protein 显示文摘 | Chan HM Krstic-Demonacos M Smith L | 2001 | Nat Cell Biol2001，3，7： | 1 |
| 9 | Disintegration of yeast cells by pressurized carbon dioxide 显示文摘 | Lin HM Chan EC Chen CS | 1991 | Biotechnology Progress1991，，7： | 1 |
| 10 | Endogenous bacterial endo- phthalmitis:an east Asian experience and a reappraisal of a se- vere ocular affliction 显示文摘 | Wong JS Chan TK Lee HM | 2000 | Ophthalmology2000，107，8： | 1 |
| 11 | Long-term clinical outcome of spontaneous carotid cavernous sinus fistulae supplied by branches of the internal carotid artery显示文摘 | Liu HM Wang YH Chan YE | 2001 | Neuroradiology2001，43，： | 1 |
| 12 | Methylmercury increases N- methyl-D-aspartate receptors on human SH-SY 5Y neuroblastoma cells leading to neurotoxicity 显示文摘 | Ndountse LT Chan HM | 2008 | Toxicology2008，249，： | 1 |
| 13 | alpha 1 -Proteinase inhibitor in gingival crevicular fluid of humans with adult periodontitis: serpinolytic inhibition by doxycycline 显示文摘 | Lee HM Golub LM Chan D | 1997 | J Periodontal Res1997，32，11： | 1 |
| 14 | Identification and character- ization of SPOCK1 in HCC development 显示文摘 | Li Y Chan HM Chen L | 2011 | Cancer Re- search2011，71，8： | 1 |
| 15 | Monophasic, solitary tumefactive demyeIinating lesion: neuroimaging features and neuropathological diagnosis 显示文摘 | Chan LL Chuah KL | 2004 | Br J Radiol2004，77，914： | 1 |
| 16 | Upregulation of macrophnge migration inhibitory factor contributes to induced N-Myc expression by the activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma显示文摘 | Ren Y Chan HM Li Z | 2004 | Oncogene2004，23，23： | 1 |
| 17 | Prediction for distant failure in patients with stage Mo nasopharyngeal carcinoma: the role of standardized uptake value显示文摘 | Chan SC Chang JT Wang HM | 2009 | Oral Oncol2009，45，1： | 1 |
| 18 | 2D-3D vascular registration between digital subtraction angiographic(DSA) and magnetic resonance angiographic (MRA) images显示文摘 | Chan HM Chung ACS Yu SCH | 1999 | IEEE International Symposium on Biomedical Image1999，，1： | 1 |
| 19 | 显示文摘 | Chan NN Vallance P Colhoun HM | 2000 | Diabetologia2000，43，： | 1 |
| 20 | Composition vector method based on maximum entropy principle for sequence comparison显示文摘 | Chan RH Chan TH Yeung HM | 2012 | IEEE/ACM Transactions on Computational Biology and Bioinformatics2012，9，1： | 1 |
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