|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation显示文摘AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls.METHODS: Constipation was diagnosed by Rome Ⅱ criteria.Coping ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were performed.RESULTS: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P<0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology. | Annie OO Chan Cecilia Cheng Wai Mo Hui Wayne HC Hu Nina YH Wong KF Lam Wai Man Wong Kam Chuen Lai Shiu Kum Lam Benjamin CY Wong | 2005 | World Journal of Gastroenterology2005，11，34： | 92 |
| 2 | 堆石体宏细观力学特性演化机制的离散元模拟显示文摘以具有尖角的堆石颗粒材料为研究对象,采用自主开发的多边形离散单元法程序PDEM对其在双轴压缩试验过程中的宏-细观力学特性及变形破坏机制进行系统分析.根据数值试验中试样在不同围压下应力及变形的发展,从颗粒运动角度探讨试样宏观应力应变剪胀特性演化的细观机制;细观组构与宏观应力变形的发展之间具有同步性,反映试样宏细观演化的统一性;通过对颗粒细观各向异性的统计分析,揭示颗粒间摩擦及咬合作用是维持细观力学结构相对稳定的重要因素;通过对力链网络的形态演化分析,发现试样大主应力方向与各向异性主方向一致,力链密集程度随压缩过程先上升后下降,试样孔隙度也随之先减小后增大,反映了试样宏观先减缩后剪胀的特性. | 罗滔 李刚 OOIE T CHAN A HC 傅少君 邹维列 | 2018 | 武汉大学学报(工学版)2018，51，7： | 4 |
| 3 | A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection显示文摘Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection.In this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls.Moreover,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice.Consistent with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture.Taken together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. | Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu | 2011 | Cellular & Molecular Immunology2011，8，6： | 2 |
| 4 | Standardisation and adap- tation of the Denver Developmental Screening Test (DDST) and Denver Ⅱ for use in Singapore children显示文摘 | Lira HC Chan T Yooug T | 1994 | Singapore Med J1994，35，2： | 1 |
| 5 | An antimicrobial peptide gene found in the male reproductive system of rats显示文摘 | Li P Chan HC He B | 2001 | Science2001，291，5509： | 1 |
| 6 | HAb18G/CD147-mediated calcium mobilization and hepatoma metastasis require both C-terminal and N-terminal domains显示文摘 | Jiang JL Chan HC Zhou Q | 2004 | Cell Mol Life Sci2004，61，16： | 1 |
| 7 | Cigarette smoking is an inde- pendent risk factor for type 2 diabetes: a four year community- based prospective study 显示文摘 | Cho NH Chan JC Jang HC | 2009 | Clinical Endocrinology2009，71，5： | 1 |
| 8 | The effects of eradication of Helicobacter pylori on the recurrence of duodenal ulcers in patients with cirrhosis显示文摘 | Lo GH Yu HC Chan YC | | 0，，03： | 1 |
| 9 | An antimicrobial peptide gene found in the male reproductive system of rats显示文摘 | Li P Chan HC He B | 2001 | Science2001，291，5509： | 1 |
| 10 | Fixation of distal radius fractures using Ao titanium volar distal radius plate显示文摘 | Lec Hc Wong YS Chan Bk el al | 2003 | Hand Surg2003，8，： | 1 |
| 11 | One pot phase transfer synthesis of O-alkyl, S-methyl dithioearbonates (xanthates) 显示文摘 | Lee AWM Chan WH Wong HC | 1989 | Synth Commun1989，19，34： | 1 |
| 12 | Angiotensin Ⅱ receptors, AT1 and AT2 in the rat epididymis: immunocytochemical and electrophysiological studies显示文摘 | Leung PS Chan HC Fu LXM | 1997 | Bioch Biophys Acta1997，1357，1： | 1 |
| 13 | Ablation of haemodynamically unstable right ventricular outflow tract ventricular tachycardia guided by non-contact mapping显示文摘 | Fung JW Chan HC Sanderson JE | 2002 | Heart2002，87，1： | 1 |
| 14 | Expression of sperm Ca2+-activated K+ channels in Xenopus oocytes and their modulation by extracellular ATP显示文摘 | Chan HC Wu WL Sun YP | | 0，，： | 1 |
| 15 | A new constrained weigh- ted least squares algorithm for TI)OA-based localization 显示文摘 | Lin L So HC Chan FKW | 2013 | Signal Processing2013，93，11： | 1 |
| 16 | BAG3-related myofibrillar myopathy in a Chinese family显示文摘 | Lee HC Cherk SW Chan SK | 2012 | Clin Genet2012，81，： | 1 |
| 17 | 经皮冠状动脉介入后阻塞性睡眠呼吸暂停与心血管事件的关系显示文摘目前关于阻塞性睡眠呼吸暂停(obstructive sleepapnea,OSA)对冠状动脉疾病患者的预后意义的大型队列研究数据匮乏。该研究假设OSA可预测行经皮冠状动脉介入治疗(percutaneous coronary intervention.PCI)患者未来主要不良心脏和脑血管事件(major adverse cardiac and cerebrovascularevents,MACCE)。方法:睡眠及支架研究是一项前瞻性、多中心注册研究,纳入2011年12月和2014年4月来自5个国家经PCI治疗成功的患者1748例。 | Lee CH Sethi R Li R Ho HH Hein T Jim MH Loo G Koo CY Gao XF Chandra S Yang XX Furlan SF Ge Z Mundhekar A Zhang WW Ucha CH Kharwar RB Chan PF Chen SL Chan MY Richards A Tan HC Ong TH Roldan G Tai BC Drager LF Zhang JJ 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，5： | 1 |
| 18 | The significance of thrombocytopenia in the development of postoperative intracranial homatoma显示文摘 | Kwan HC Kirpal SM Chan TK | 1989 | J Neurosurg1989，71，： | 1 |
| 19 | Different regulatory pathways involved in ATP-stimulated chloride secretion in rat epididymal epithelium显示文摘 | Chan HC Zhou WL Fu WO Ko WH Wong PY | | 0，，： | 1 |
| 20 | Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma显示文摘 | Chan HC Chang RCC Koon-Ching Ip A Chiu K Yuen WH Zee SY et at | 2007 | Exp Neurol2007，203，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员