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| 1 | Management of hepatocellular carcinoma with portal vein tumor thrombosis: Review and update at 2016显示文摘Portal vein tumor thrombosis(PVTT) is a common phenomenon in hepatocellular carcinoma(HCC). Compared to HCC without PVTT, HCC with PVTT is characterized by an aggressive disease course, worse hepatic function, a higher chance of complications related to portal hypertension and poorer tolerance to treatment. Conventionally, HCC with PVTT is grouped together with metastatic HCC during the planning of its management, and most patients are offered palliative treatment with sorafenib or other systemic agents. As a result, most data on the management of HCC with PVTT comes from subgroup analyses or retrospective series. In the past few years, there have been several updates on management of HCC with PVTT. First, it is evident that HCC with PVTT consists of heterogeneous subgroups with different prognoses. Different classifications have been proposed to stage the degree of portal vein invasion/thrombosis, suggesting that different treatment modalities may be individualized to patients with different risks. Second, more studies indicate that more aggressive treatment, including surgical resection or locoregional treatment, may benefit select HCC patients with PVTT. In this review, we aim to discussthe recent conceptual changes and summarize the data on the management of HCC with PVTT. | Stephen L Chan Charing CN Chong Anthony WH Chan Darren MC Poon Kenneth SH Chok | 2016 | World Journal of Gastroenterology2016，22，32： | 44 |
| 2 | Symptom clusters and quality of life among patients with advanced heart failure显示文摘ObjectivesTo 与先进的心失败(HF ) 和与他们 .MethodsThis 是的生活(QoL ) 的质量的独立关系在病人之中识别症状簇会见了 119 个病人与的代表性的研究的第二等的数据分析在香港在一所地区性的医院的衰老老人单位推进了 HF。症状侧面和 QoL 被使用埃德蒙顿症状评价规模(ESAS ) 和 McGill QoL 问询表估计。探索因素分析被用来识别症状簇。层次回归分析被用来与他们的 QoL 检验独立关系,在调整病人们在先进年龄的年龄,性,和 comorbidities.ResultsThe 的效果以后(82.9 ±6.5 年) 。三不同症状簇被识别:他们是悲痛簇(呼吸,焦虑,和消沉的包括的短小) , decondition 簇(疲劳,睡意,恶心,和减少的胃口) ,和不快聚类(概括不快的疼痛,和感觉) 。这三症状簇说明了病人症状经验的 63.25% 变化。对在这些症状簇之间的中等关联小显示他们是独立人士互相。在调整年龄,性和 comorbidities 以后,悲痛(β=− 0.635, P <0.001 ) , decondition (β=− 0.148, P = 0.01 ) ,并且不快(β=− 0.258, P <0.001 ) 症状簇独立地预言他们的 QoL.ConclusionsThis 学习与先进 HF 在病人之中识别了特殊症状簇。结果使需要清楚些为为这限制生活的疾病优化症状控制开发辩解的照顾干预。 | Doris SF Yu Helen YL Chan Doris YP Leung Elsie Hui Janet WH Sit | 2016 | Journal of Geriatric Cardiology2016，13，5： | 12 |
| 3 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 4 | Information needs of older people with heart failure: listening to their own voice显示文摘 | Ming-Ming YU Sek Ying Chair Carmen WH Chan Kai Chow Choi | 2016 | Journal of Geriatric Cardiology2016，13，5： | 2 |
| 5 | Significance of a positive oesophageal margin in stomach cancer 显示文摘 | Chan WH Wong WK Khin IW | 2000 | Ausl NIJ Surg2000，70，10： | 1 |
| 6 | Prevalence of gestational diabetes mellitus in Hong Kong based on the 1998 WHO criteria显示文摘 | Ko GT Tam WH Chan JC | 2002 | Diabet Med2002，19，1： | 1 |
| 7 | Effects of TGF-13s on the growth, collagen synthesis and collagen lattice contrac- tion of human dental pulp fibroblasts in vitro显示文摘 | Chan CP Lan WH Chang MC | 2005 | Arch Oral Biol2005，50，5： | 1 |
| 8 | Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention : a randomized controlled trial 显示文摘 | Kay J Chow WH Chan TM | 2003 | JAMA2003，289，： | 1 |
| 9 | Inhibition of irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermal carcinoma A431 ccUsby genistein 显示文摘 | Chan WH Yu JS | 2000 | Cell Diochem2000，78，1： | 1 |
| 10 | Oral fluid therapy显示文摘 | Younoszai AK Franklin WH Chan DP | 1998 | Arch Pediatr Adolesc Med1998，152，2： | 1 |
| 11 | CdSe quantum dots induce apotosis in human neuroblastoma cells via mitochondfial- dependent pathways and inhibition of survival signal显示文摘 | CHAN WH SHIAO NH LU PZ | 2006 | Toxicol Lett2006，167，： | 1 |
| 12 | Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial 显示文摘 | Kay J Chow WH Chan TM | 2003 | JAMA2003，289，5： | 1 |
| 13 | Primary non-Hodgkin's lymphoma of the nose and nasopharynx:clinical features,tumor immunophenotype,and treatment outcome in 113 patients显示文摘 | Cheung MM Chan JK Lau WH | 1998 | J Clin Oncol1998，16，1： | 1 |
| 14 | Prevalence and genotype distribution of cervical human pap illomavirus infection:Comparison between pregnant women and non-pregnant controls显示文摘 | Chan PK Chang AR Tam WH | 2002 | J Med Virol2002，67，： | 1 |
| 15 | raceaniso-daminefor the treatment of childhood myopia 显示文摘 | Chua WH Balakrishuan V chan YH | 2006 | ophthatha-lmolgy2006，113，12： | 1 |
| 16 | Prostate cancer progression:results from the search database显示文摘 | Lindblad P Chow WH Chan J | | 0，，01： | 1 |
| 17 | Early stage nasal NK/T-cell lymphoma: clinical outcome, prognostic factors, and the effect of treatment modality显示文摘 | Cheung MM Chan JK Lau WH | 2002 | Int J Radiat Oncol Biol Phys2002，54，1： | 1 |
| 18 | Prognostic significance of peritoneal lavage cytology in gastric cancer in Singapore显示文摘 | Chuwa EW Khin LW Chan WH | 2005 | Gastric Cancer2005，8，4： | 1 |
| 19 | High prevalence of human papillomavirus type 58 in Chinese women with cervical cancer and precancerous lesions显示文摘 | Chan PK Li WH Chan MY | 1999 | J Med Virol1999，59，2： | 1 |
| 20 | Long-term improvement in homocystein levels and arterial endothelial function after 1-year folic acid supplementation显示文摘 | Woo KS Chook P Chan LL Cheung AS Fung WH Oiao M | 2002 | Am J Med2002，112，7： | 1 |
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