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| 1 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | 一种应用光学相干断层扫描报道黄斑增厚改变的标准化方法显示文摘目的:描述一种应用光学相干断层扫描(OCT)报道黄斑增厚定量改变的标准化方法。
方法:我们所推荐的方法由以下内容组成:用OCT计算中心凹增厚的实际改变值(治疗前的原始厚度减去治疗后的厚度)并除以可能变化值(治疗前的原始厚度减去根据标准值确定的正常厚度)。作为总体黄斑水肿改善的百分比。我们将这种方法称为标准化黄斑增厚改变(SCMT)。为阐明这种方法的有效性。我们对2项评价不同治疗方案治疗顽固性黄斑水肿的研究作了回顾性复阅。
结果:接受玻璃体内注射丙酮化曲安奈德治疗顽固性糖尿病黄斑水肿的患者在1,3和6个月随诊检查时的总体SCMT值分别近似为75%。78%和55%。研究组中超过半数的(16例患者中的9例)患者在末次随访时的SCMT大于80%。接受玻璃体切割手术治疗牵拉性增厚的后部玻璃体膜患者oCT显示在3个月和末次随诊(平均数,19个月)时SCMT好转分别大约是78%和87%。对激光光凝不敏感但没有玻璃体黄斑牵拉迹象而接受玻璃体切割手术治疗糖尿病性黄斑水肿的患者在3个月和末次随诊(平均数。17个月)时SCMT分别是37%和20%。
结论:我们所推荐的这种方法为评价和比较不同治疗方案的功效提供了一种客观而又直观的准则。 | Annie Chan, BS Jay S. Duker 耿韶辉(译) 申敏如(校) | 2006 | 美国医学会眼科杂志(中文版)2006，18，3： | 3 |
| 3 | Centration analysis of abla-tion over the coaxial corneal light reflex for hyperopic LASIK显示文摘 | Chan CC Boxer Wachler BS | 2006 | J Refract Surg2006，22，5： | 1 |
| 4 | Infliximab for GVHD therapy in children 显示文摘 | Sleight BS Chan KW Braun TM | 2007 | Bone Marrow Transplant2007，40，5： | 1 |
| 5 | Centration analysis of ablation over the coaxial corneal light reflex for hyperopic LASIK 显示文摘 | Chan CC Boxer Wachler BS | 2006 | J Refraet Surg2006，22，5： | 1 |
| 6 | Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodiuminduced colitis显示文摘 | Khor TO Huang MT Kwon KH Chan JY Reddy BS Kong AN | 2006 | Cancer Res2006，66，11： | 1 |
| 7 | Disseminated penicilliosis,re-current bacteremic nontyphoidal salmonellosis,and burkholderio-sis associated with acquired immunodeficiency due to autoantibodyagainst gamma interferon显示文摘 | Tang BS Chan JF Chen M | 2010 | Clin Vaccine Immunol2010，17，7： | 1 |
| 8 | Effect of inferior seg-ment Intacs with and without C3-R on keratoconus显示文摘 | Chan CC Sharma M Wachler BS | 2007 | J Cataract Refract Surg2007，33，： | 1 |
| 9 | Effect of epithelial debridement in corneal collagen crosslinking therapy in porcine and human eyes显示文摘 | Yuen L Chan C Boxer Wachler BS | 2008 | J Cataract Refract Surg2008，34，11： | 1 |
| 10 | Increased iris thickness and association with pri- mary angle closure glaucoma 显示文摘 | Wang BS Narayanaswamy A Amerasinghe N Zheng C He M Chan YH | 2011 | Br J Ophthalmol2011，95，1： | 1 |
| 11 | Higher order sbrrations and relative risk of symptoms after LASIK显示文摘 | Sharma M Wachler BS Chan CC | 2007 | J Refract Surg2007，23，3： | 1 |
| 12 | The renal excretory mechanisms and the role of organic cations in modulating the renal handling of paraquat显示文摘 | Chan BS Lazzaro VA Seale JP | 1998 | Pharmacol Ther1998，79，： | 1 |
| 13 | The balance between pro-apoptotic and anti-apoptotic pathways in the failing myocardium 显示文摘 | McGowan BS Ciccimaro EF Chan TO | 2003 | Cardiovasc Toxicol2003，3，3： | 1 |
| 14 | The Alvarado score and acute appendicitis 显示文摘 | Chan MY Teo BS Ng BL | 2001 | Ann Acad Med Singapore2001，30，5： | 1 |
| 15 | The alvarado score and acute appendicitis 显示文摘 | Chan MY Teo BS Ng BL | 2001 | Annals of the Academy of Medieine Singapore2001，30，5： | 1 |
| 16 | Cost of type 2 diabetes mellitus in Hong Kong Chinese显示文摘 | Chan BS Tsang MW Lee VW | 2007 | Int J Clin Pharmacol Ther2007，45，8： | 1 |
| 17 | Cost(ff lypc 2 diabetes mellitus in Hong Kong Chinese显示文摘 | Chan BS TsangMW LeeVW | 2007 | Int J Clin Phczrmacul Ttzer2007，45，8： | 1 |
| 18 | Use of interdental distraction osteogenesis for orthodontic tooth alignment and correction of maxillary hypoplasia:A case report显示文摘 | Tong AC Yan BS Chan TC | 2003 | Br J Oral Maxillofac Surg2003，41，3： | 1 |
| 19 | Centration analysis of abla- tion over the coaxial corneal light reflex for hyperopie LASIK 显示文摘 | Chan CC Boxer Wachler BS | 2006 | J Refract Surg2006，22，： | 1 |
| 20 | The Alvarado score and acute appendici-tis显示文摘 | Chan MY Teo BS Ng BL | 2001 | An Aead Med Singapore2001，30，5： | 1 |
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