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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | Synthesis and evaluation of new arylbenzothiophene and diarylthiophene derivatives as inhibitors of the NorA multidrug transporter of Staphylococcus aureus显示文摘 | Fournier Dit Chabert J Marquez B Neville L | 2007 | Bioorg Med Chem2007，15，13： | 1 |
| 3 | Results of Non-operative Therapy for Delayed Hemorrhage after Pancreaticoduodenectomy显示文摘 | Laura Beyer Rémi Bonmardion Sandrine Marciano Olivier Hartung Olivier Ramis Léna?k Chabert Marc Léone Olivier Emungania Pierre Orsoni Marc Barthet Stéphane V. Berdah Christian Brunet Vincent Moutardier | 2009 | Journal of Gastrointestinal Surgery2009，，5： | 1 |
| 4 | Responseof an ion-ion plasma to dc biased electrodes显示文摘 | POPELIER L AANESLAND A CHABERT P | 2011 | Journal ofPhysics D: Applied Physics2011，44，31： | 1 |
| 5 | Microfluidic high-throughput encapsulation and hydrodynamic self-sorting of single cells显示文摘 | Chabert M Viovy J L | 2008 | Proceedings of the National Academy of Sciences of the United States of America2008，105，： | 1 |
| 6 | Particle-in-cell simulation of an electronegativeplasma under direct current bias studied in a largerange of electronegativity显示文摘 | OUDINI N RAIMBAULT j L CHABERT P etal | 2013 | Physics Plasma2013，20，04： | 1 |
| 7 | Synthesis and evaluation of new arylbenzo thiophene and diarylthiophene derivatives as inhibitors of the NorA multidmg transporter of Staphylococcus aureus显示文摘 | Chabert JFD Marquez B Neville L | 2007 | BIOORGANIC & MEDICINAL CHEMISTRY2007，15，13： | 1 |
| 8 | Inductive Heating and E to H Transitions in Capacitive Discharges 显示文摘 | Chabert P Raimbauh J L Levif P | 2005 | Phys Rev Lett2005，15，2： | 1 |
| 9 | Study of the interfa cial degradation of a glass epoxy composite during hygrothermal ageing using water diffusion measurements and dynamic mechan ical thermal analysis 显示文摘 | Vincent L Chabert B | 1994 | Polymer1994，35，： | 1 |
| 10 | Preliminary results ofrobot-assisted laparoscopic radical prostatectomy ( RALP) afterfellowship training and experience in laparoscopic radicalprostatectomy ( LRP) 显示文摘 | Wolanski P Chabert C Jones L | 2012 | BJU Int2012，110，： | 1 |
| 11 | Suppression of the Standing Wave Effect in High Frequency Capacitive Discharges Using a Shaped Electrode and a Dielectric Lens:Self-Consistent Approach显示文摘 | Chabert P Raimbault J L Rax J M | 2004 | Physics of Plasmas2004，11，08： | 1 |
| 12 | Spontaneous chronic spinal epidural hematoma of the lumbar spine显示文摘 | Riffaud L Morandi X Chabert E Brassier G | | 0，，： | 1 |
| 13 | Java Object sharing in Habaneo 显示文摘 | Chabert A Grossman E Jackson L | 1998 | Communications of the ACM1998，41，6： | 1 |
| 14 | Droplet fusion by alternating current (Ac) field electrocoalescence in microchannels显示文摘 | Chabert M Dorfman K D Viovy J L | 2005 | Electrophoresis2005，26，： | 1 |
| 15 | Morphology and mechan- ical performance of polyphenylene sulfide carbon fiber composite 显示文摘 | Caramaro L Chabert B Chauchard J | 1991 | Polymer Engineering and Science1991，31，17： | 1 |
| 16 | Study of the interfacial degradation of a glass-epoxy composite during bygrothermal ageing using water diffusion measurements and dynamic meachanical thermal analysis显示文摘 | Chateauminois A Vincent L Chabert B | 1994 | Polymer1994，35，： | 1 |
| 17 | Double lumen tube intubation systematic verification with fiberoptic bronchoscopy : between what who should do and what we can do显示文摘 | Gaillat F Duponq R Chabert L | 2011 | Eur J Cardiothorac Surg2011，40，4： | 1 |
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