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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | Management of acute intestinal arterial ischemia显示文摘 | Chabert S Porcheron J Balique JG | 1999 | J Chir1999，136，3： | 2 |
| 3 | A model for the self- pulsing regime of microhollow cathode discharges显示文摘 | Chabert P Lazzaroni C Rousseau A | 2010 | Journal of Applied Physics2010，108，11： | 1 |
| 4 | Pleiotropy of insecticide resistance in the codling moth, Cydia pomonella 显示文摘 | Boivin T Chabert d' Hieres C Bouvier J C | 2001 | Entomologia Experimentalis et Applicata2001，99，： | 1 |
| 5 | New experimentalsetup for wettability characterization under monitored oxygenactivity: II, wettability of sapphire by silver-oxygenmelts 显示文摘 | Chatain D Chabert F Ghetta V | 1994 | Journal of the American Ceramic Society1994，77，1： | 1 |
| 6 | Synthesis and evaluation of new arylbenzothiophene and diarylthiophene derivatives as inhibitors of the NorA multidrug transporter of Staphylococcus aureus显示文摘 | Fournier Dit Chabert J Marquez B Neville L | 2007 | Bioorg Med Chem2007，15，13： | 1 |
| 7 | Interval method for calibration ofparallel robots: Vision-based experiments 显示文摘 | Daney D AndreffN Chabert Q | 2006 | Mechanism andMachine Theory (S0094-114x)2006，41，8： | 1 |
| 8 | Diffusion tensor ima- ging of the human optic nerve using a non-CPMG fast spin echo sequenee显示文摘 | Chabert S Molko N Cointepas Y | 2005 | J Magn Reson Imag2005，22，2： | 1 |
| 9 | An interpolation-based watermarking scheme 显示文摘 | Martin V Chabert M Lacaze B | 2008 | Signal Processing2008，88，： | 1 |
| 10 | Chaotic mixing in cross-channel micmmixers显示文摘 | TABELING P CHABERT M DODGE A | 2004 | Royal Society of London Transactions Series A2004，362，1818： | 1 |
| 11 | Management of acute in- testinal arterial ischemia 显示文摘 | Chabert S Porcheron J Balique JG | 1999 | J Chit1999，136，3： | 1 |
| 12 | Analysis of cerebrovascular diseases by a new 3-dimensional computerized X-ray angiography system显示文摘 | Heautot J F Chabert E Gandon Y | 1998 | Neuroradiology1998，40，12： | 1 |
| 13 | Resveratrol analog (Z)-3,5,4'-trimethoxystilbene is a potent anti-mitotic drug inhibiting tubulin polymerization显示文摘 | Schneider Y Chabert P Stutzmann J | 2003 | Int J Cancer2003，107，2： | 1 |
| 14 | Analysis of cerebrovascular diseases by a new 3-demensional computerized X-ray angiography system显示文摘 | Heautot J F Chabert E Gandon Y | 1998 | Neuroradiology1998，40，4： | 1 |
| 15 | Analysis of cerebrovascular diseases by a new 3-dimensional computerized X-ray angiography system显示文摘 | Heautot JF Chabert E Gandon Y | 1998 | Neuroradiology1998，40，4： | 1 |
| 16 | Particular crystalline superstructures appearing at the interface of polypropylene/glass fiber composites during a nonisothermal crystallization from the melt显示文摘 | Devaux S E Chabert B | 1991 | Polym Commun1991，32，： | 1 |
| 17 | Analysis of cerebrovascular disease by a new 3-dimensional computerized X-ray angiography system显示文摘 | Heautot JF Chabert E Gandon Y | 1998 | Neuroradiology1998，40，4： | 1 |
| 18 | From polymer chemistry to membrane elaboration: A global approach of fuel cell polymeric electrolytes显示文摘 | Iojoiu C Chabert F Mar6chal M | 2006 | Journal of Power Sources2006，153，2： | 1 |
| 19 | Management of acute intestinal arterial ischemia 显示文摘 | Chabert S Porcheron J Balique J G | 1999 | J Chir ( paris )1999，136，3： | 1 |
| 20 | Deep etching of silicon carbide for micromachining applications:etch rates and etch mechanisms显示文摘 | CHABERT P | 2001 | J Vat Sci Technol:B2001，19，4： | 1 |
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