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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Robust Array Beamforming with Sidelobe Control Using Support Vector Machines 显示文摘 | Cesar C G Ignacio S Javier V | 2007 | IEEE Trans on Signal Processing2007，55，2： | 1 |
| 3 | Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3receptors显示文摘 | Souslova V Cesare P Ding Y | 2000 | Nature2000，407，6807： | 1 |
| 4 | Robust array beam- forming wit h sidelobe cont rolusing support vector machines 显示文摘 | Cesar C G Ignacio S J avier V | 2007 | IEEE Transactions on Signal Processing2007，55，2： | 1 |
| 5 | maternal and child undemutrition: Consequcnces for adult health and human capital 显示文摘 | CESAR G V LINDA A CAROLINE F | 2008 | The lancet2008，371，9607： | 1 |
| 6 | Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor,RC307:enhanced DNA damage response显示文摘 | Zuco V Benedetti V Cesare MD | 2008 | Oncol Rep2008，20，5： | 1 |
| 7 | A wavelet supspace method for real-time face tracking 显示文摘 | Feris R V Krueger R Cesar | 2004 | Real-Time Imaging2004，10，7： | 1 |
| 8 | Ion channels gated by heat 显示文摘 | Cesare P Moriondo A Vellani V | 1999 | Proceedings of the National Academy of Sciences of the United States of America1999，96，14： | 1 |
| 9 | The recreational value of coral reefs : A meta-analysis显示文摘 | Brander L M Beukering P V Cesar H SJ | 2007 | Ecological Economics2007，63，1： | 1 |
| 10 | Organizational innovation as an enabler of technological innovation capabilities and firm performance 显示文摘 | CESAR C ANA V | 2014 | Journal of Business Research2014，67，1： | 1 |
| 11 | Retinal vessel segmentation using the 2-D Gabor wavelet and supervised classification显示文摘 | Soares J V B Leandro J J G Cesar R M | 2006 | IEEE Transactions on Medical Imaging2006，25，9： | 1 |
| 12 | Ion channels gated by heat 显示文摘 | Cesare P Moriondo A Vellani V | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 13 | Comparatve evaluation of TEE,Conventional MRI and contrast enhance 3D breath-hold MRA in the post-operative follow-up of dissecting aneurysms显示文摘 | CESARE E D GIORDANO A V CERONE G | 2000 | Int J Card Imaging2000，16，： | 1 |
| 14 | Cardiopulmonary responses to exercise in patients of different age group with conges tive heart failure显示文摘 | Cesar Mde C Montesano F T Diniz R V | 2006 | Arq Bras Cardiol2006，86，1： | 1 |
| 15 | Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors 显示文摘 | Souslova V Cesare E Ding Y | 2000 | Nature2000，407，： | 1 |
| 16 | Carbon nanofibres and activated carbon nanofibres as electrodes in supercapacitors 显示文摘 | CESAR M PABLO S EDUARDO V | 2005 | Carbon2005，43，3： | 1 |
| 17 | Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors显示文摘 | Souslova V Cesare P Ding Y | 2000 | Nature2000，407，6807： | 1 |
| 18 | Synergistic antitu?mor activity of cetuximab and namitecan in human squa?mous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number显示文摘 | Zuco V Cesare MD Veronese MS et a1 | 2013 | Clinical Cancer Res2013，20，4： | 1 |
| 19 | Retinal vessel segmentation using the 2-D gabor wavelet and supervised classification显示文摘 | SOARES J V B LEANDRO J J G CESAR R M | 2006 | IEEE Transactions on Medical Imaging2006，25，9： | 1 |
| 20 | Buchwald-Hartwig Amination of(Hetero)Aryl Tosylates Using a Well-Defined NHeterocyclic Carbene/Palladium(11)Precatalyst显示文摘 | Zhang Y Lavigne G Cesar V | 2015 | J Org Chem2015，80，： | 1 |
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