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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | System reliability and sensitivity factors via the MPPSS method 显示文摘 | Sues R H Cesare M A | 2005 | Probabilistic Engineering Mechanics2005，20，2： | 1 |
| 3 | Retinal vessel segmentation using the 2-D Gabor wavelet and supervised classification显示文摘 | Soares J V B Leandro J J G Cesar R M | 2006 | IEEE Transactions on Medical Imaging2006，25，9： | 1 |
| 4 | Ran- dom feature weights for decision tree ensemble con- struction 显示文摘 | JESUS M JUAN J R CESAR G O NICLOAS G P | 2012 | Information Fusion2012，13，： | 1 |
| 5 | System reliability and sensitivity factor via the MPPSS method显示文摘 | Sues R H Cesare M A | 2005 | Prob Eng Mech2005，20，： | 1 |
| 6 | Reduction of ketones and aldehydes to alcohols with magnesium-aluminium mixed oxide and 2-propanol 显示文摘 | Jose R R Cesar J S Julia M H | 2006 | Journal of Molecular Catalysis A : Chemical2006，246，： | 1 |
| 7 | Meerwein-Ponndorf-Verley reaction of acetophenones with 2-propanol over MgA1 mixed oxide: the substituent effect 显示文摘 | Jose R R Cesar J S Julia M H | 2007 | Catalysis Communications2007，，8： | 1 |
| 8 | Relationship between follicle size and ultrasound-guided transvaginal oocyte recovery显示文摘 | MARCELO M S CESAR R E JOAQUIM M G etal | 2001 | Anim Reprod Sci2001，67，： | 1 |
| 9 | Reduction of heterocyclic carboxaldehydes via Meerwein-Ponndorf-Verley reaction 显示文摘 | Cesar J S Julia M H Jose R R | 2006 | Applied Catalysis A : General2006，303，： | 1 |
| 10 | Retinal vessel segmentation using the 2-D gabor wavelet and supervised classification显示文摘 | SOARES J V B LEANDRO J J G CESAR R M | 2006 | IEEE Transactions on Medical Imaging2006，25，9： | 1 |
| 11 | Reti-nal vessel segmentation using the 2-D gabor wavelet and su-pervised classification显示文摘 | SOARES J B V LEANDRO J J G CESAR R M | 2006 | Ieee Transactions on Medical Ima-ging2006，25，9： | 1 |
| 12 | Adaptive Genetic Algo- rithms for Dynamic Channel Assignment in Mobile Cellular Communication Systerns显示文摘 | Lima M A C Araujo A F R Cesar A C | 2007 | IEEE Transactions on Vehicular Technolgoy2007，56，5： | 1 |
| 13 | Influence of the properties of tropical soils in the toxicity and bioavailability of heavy metals in sewage sludge-amended lands显示文摘 | Cesar R Silva M Colonese J | 2012 | Environmental Earth Sciences2012，66，8： | 1 |
| 14 | Stiffness after total knee arthroplasty显示文摘 | Bong M R Di Cesare P E | 2004 | J Am Acad Orthop Surg2004，12，3： | 1 |
| 15 | System reliability and sensitivity factor via the MPPSS method显示文摘 | SUES R H CESARE M A | 2005 | Probabilistic Engineering Mechanics2005，20，2： | 1 |
| 16 | Bone density around titanium implants may be influenced by intermittent cigarette smoke inhalation : a histometric study in rats 显示文摘 | NOCITI FH J R CESAR N J CARVALHO M D | 2002 | Int J Oral Maxillofac Implants2002，17，3： | 1 |
| 17 | Interactions between arbuscular mycorrizal fungi other microbial inocants(Azospirillum,Pseudomonas,Trichoderma)and their effects on microbial population and enzyme activities in the rhizosphere of maize plants显示文摘 | Vazquez M M Cesar S Azco n R | 2000 | Applied Soil Ecology2000，15，： | 1 |
| 18 | Highly efficient dye-sensitized solar cells based on carbon black counter electrodes显示文摘 | MURAKAMI T N ITO S WANG Q NAZEERUDDIN M K BESSHO T CESAR L LISKA P BAKER R H COMTE P PECHY P GRATZEL M | 2006 | Journal of the Electrochemical Society2006，153，12： | 1 |
| 19 | System reliability and sensitivity factor via the MPPSS method 显示文摘 | Sues R H Cesare M A | 2005 | Probabilistic Engineering Mechanics2005，20，2： | 1 |
| 20 | Interactions between arbuscular mycorrhizal fungi and other microbial inoeulants (Azospirillum, Pseudomonas, Triehoderma) and their effects on microbial population and enzyme activities in the rhizosphere of maize plants显示文摘 | Mar Vazquez M Cesar S Azcon R | 2000 | Applied Soil Ecology2000，15，3： | 1 |
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