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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Composition and distribution of volatile compounds in feijoa fruit grown in Italy显示文摘 | Di Cesare Nani R | 1965 | Industrie Alimentari1965，34，49： | 1 |
| 3 | Scaffolds for articular cartilage repair annals of biomedical egineering显示文摘 | Sally R Frenkel PE Di Cesare | 2004 | Annals of Biomedical Engineering2004，32，： | 1 |
| 4 | Virtual laboratory for planetary materials: System service architecture overview显示文摘 | CESAR R S PEDRO R C BIJAYA K | 2007 | Physics of the Earth and Planetary Interiors2007，163，8： | 1 |
| 5 | Aero- monas hydrophila clinical and environmental ecotypes as revealed by genetic diversity and virulence genes 显示文摘 | MaGuadalupe A A Cesar H R Gerardo Z | 2005 | FEMS Microbiol Lett2005，，10： | 1 |
| 6 | Variable epitope library-based vaccines:shooting moving targets显示文摘 | CESAR P R CLAUDIA C N RAFAEL S | 2009 | Molecular Immunology2009，47，2： | 1 |
| 7 | A wavelet supspace method for real-time face tracking 显示文摘 | Feris R V Krueger R Cesar | 2004 | Real-Time Imaging2004，10，7： | 1 |
| 8 | Interactions of posaconazole and flucytosine against Cryptococcus neoformans 显示文摘 | Barchiesi F Schimizzi AM Najvar LK Bocanegra R Caselli F Cesare SD | 2001 | Antimicrob Agents Chemother2001，45，5： | 1 |
| 9 | System reliability and sensitivity factors via the MPPSS method 显示文摘 | Sues R H Cesare M A | 2005 | Probabilistic Engineering Mechanics2005，20，2： | 1 |
| 10 | Chloroplast isolation from Laminaria digitata:A reproducible methodology yielding photosynthetically active chloroplasts显示文摘 | STRBAC D MARCOAURELIO A R CESAR P | 1994 | Planta1994，195，： | 1 |
| 11 | Acid and base catalysts in the hybrid silica sol-gel process显示文摘 | Cesar R Silva Claudio Airoldi | 1997 | J Colloid Int Sci1997，195，2： | 1 |
| 12 | Failure analysis of crude oil pipeline 显示文摘 | Cesar R F Azevdo | 2007 | Engineering Failure Analysis2007，，14： | 1 |
| 13 | Structural change of bitumen in the recycling process by using rhe- ology and NMR显示文摘 | LUIGI F LUIGI G CESARE O R | 2012 | Ind Eng Chem Res2012，51，16： | 1 |
| 14 | Evaluation of resveratrol and piceatannol cytotoxicity in macrophages, T ceils, and skin cells, cytotoxic effects of resveratrol and piceatannol显示文摘 | VIJAYALAXMI R DIANE H CESAR LC | 2007 | Arh Hig Rada Toksikol2007，58，3： | 1 |
| 15 | Retinal vessel segmentation using the 2-D Gabor wavelet and supervised classification显示文摘 | Soares J V B Leandro J J G Cesar R M | 2006 | IEEE Transactions on Medical Imaging2006，25，9： | 1 |
| 16 | Erlotinib in advaneed non-small cell lung cancer: efficacy and safety findings of the global phase IV Tareeva Lung Cancer Survival Treatment study 显示文摘 | Martin R Nico VZ Cesare G | 2010 | J Thoruc Oncol2010，5，10： | 1 |
| 17 | Proportional-integral observer for systems modeled by nond gGraphs 显示文摘 | CESAR P A AHMED R GENEVIEVE D T | 2005 | Simulation modeling practice and theory2005，13，： | 1 |
| 18 | Cardiopulmonary responses to exercise in patients of different age group with conges tive heart failure显示文摘 | Cesar Mde C Montesano F T Diniz R V | 2006 | Arq Bras Cardiol2006，86，1： | 1 |
| 19 | Ran- dom feature weights for decision tree ensemble con- struction 显示文摘 | JESUS M JUAN J R CESAR G O NICLOAS G P | 2012 | Information Fusion2012，13，： | 1 |
| 20 | System reliability and sensitivity factor via the MPPSS method显示文摘 | Sues R H Cesare M A | 2005 | Prob Eng Mech2005，20，： | 1 |
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