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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | maternal and child undemutrition: Consequcnces for adult health and human capital 显示文摘 | CESAR G V LINDA A CAROLINE F | 2008 | The lancet2008，371，9607： | 1 |
| 3 | Structural change of bitumen in the recycling process by using rhe- ology and NMR显示文摘 | LUIGI F LUIGI G CESARE O R | 2012 | Ind Eng Chem Res2012，51，16： | 1 |
| 4 | Inhibition of angiotensin converting enzyme activity by flavanol-rich foods显示文摘 | Lucas A G Javier I O Cesar G F | 2006 | Journal of Agricultural and Food Chemistry2006，54，1： | 1 |
| 5 | Relevance,essentiality and toxicity of trace ele ments in human health显示文摘 | Cesar G F | | 0，，： | 1 |
| 6 | A rapid HPLCESI-MS/MS method for determination of dihydrouracil/uracil ratio in plasma:evaluation of toxicity to 5-flurouracil in patients with gastrointestinal cancer显示文摘 | Cesar I C Cunha-Junior G F Duarte Byrro R M | 2012 | Ther Drug Monit2012，34，1： | 1 |
| 7 | Different patterns between mechanical and electrical activities: an approach to investigate gastric motility in a model of long-term diabetic rats显示文摘 | Rozemeire G Marques Madileine F Americo Cesar T Spadella Luciana A Corá Ricardo B Oliveira Jose Ricardo A Miranda | 2014 | Physiological Measurement2014，，1： | 1 |
| 8 | A minimally invasive technique for surgical treatment of hallux valgus : simple , effective , rapid 显示文摘 | Sandro G Cesare F Matteo N | 2013 | Inexpensive(SERI)2013，37，9： | 1 |
| 9 | Solar-blind UV photodetectors for large area applications 显示文摘 | CAPUTO D DE CESARE G IRRERA F | 1996 | IEEE Trans Elec Dev1996，43，9： | 1 |
| 10 | Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides显示文摘 | Claudia R G Cesar A S Ana M F | 2005 | J Pha Sci2005，94，5： | 1 |
| 11 | Impact of turbidity currents on reservoir sedimentation 显示文摘 | CESARE G D SCHLEISS A HERMANN F | 2001 | ASCE Journal of Hydraulic Engineering2001，127，1： | 1 |
| 12 | Relevance,essentiality and toxicity of trace elements in human health显示文摘 | CESAR G F | 2005 | Molecular Aspects of Medicine2005，26，： | 1 |
| 13 | Maternal and child undernutrition: Consequences for adult health and human capital显示文摘 | Cesar G V Linda A Caroline F | 2008 | The Lancet2008，371，9607： | 1 |
| 14 | Maternal and child undernutrition:Consequences for adult health and human capital显示文摘 | Cesar G V Linda A Caroline F | 2008 | The Lancet2008，371，9607： | 1 |
| 15 | Architecture and sedimentary facies evolution in a delta stack controlled by fault growth(Betic Cordillera,southern Spain,late Tortonian)显示文摘 | Fernando G Juan F Cesar V | 2006 | Sedimentary Geology2006，185，12： | 1 |
| 16 | Data structure and ejection chains for solving largescale traveling salesman problems显示文摘 | Dorabela G Cesar R Glover F | 2005 | European Journal of Operational Research2005，160，12： | 1 |
| 17 | Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction显示文摘 | Kenneth W Mahaffey Joseph A Puma N.Alejandro Barbagelata Marcelo F DiCarli Massoud A Leesar Kevin F Browne Paul R Eisenberg Roberto Bolli A.Cecilia Casas Victor Molina-Viamonte Cesare Orlandi Roger Blevins Raymond J Gibbons Robert M Califf Christopher B G | 1999 | Journal of the American College of Cardiology1999，，6： | 1 |
| 18 | Effects of eggplant (Solanum melongena) on the atherogenesis and oxidative stress in LDL receptor knock out mice (LDLR-/-) 显示文摘 | Botelho F V Eneas L R Cesar G C | 2004 | Food Chem Toxicol2004，42，： | 1 |
| 19 | FTIR microspectroscopy and SIMS study of water-poor cordierite from El Hoyazo, Spain: application to mineral and melt devolatilization显示文摘 | Della Ventura G Bellatreccia F Cesare B | 2009 | Lithos2009，113，49： | 1 |
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