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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Electronic nose and SPME techniques to monitor phenanthrene biodegradation in soil显示文摘 | De Cesare F Pantalei S Zampetti E | 2008 | Sensors and Actuators B:Chemical2008，131，1： | 1 |
| 3 | Docking and quantum mechanic studies on chlolinesterases and their inhibitiors 显示文摘 | Jose C B Cesar F S Jesus M C | 2007 | Eur J Medicinal Chem2007，42，1： | 1 |
| 4 | Evaluating land administration systems: A comparative method with an application to Peru and Honduras显示文摘 | Pablo B Jose M S Cesar F | 2010 | Land Use Policy2010，27，2： | 1 |
| 5 | Eleetronie nose and SPME techniques to monitor phenanthrene biodegradation in soil 显示文摘 | De Cesare F Pantalei S Zampetti E | 2008 | Sensors and Actuators B : Chemical2008，131，1： | 1 |
| 6 | Experiments on the wind tunnel simulation of atmospheric boundary layers显示文摘 | Cesar F Arun K S I | 1999 | Journal of Wind Engineering and Industrial Aerodynamics1999，79，： | 1 |
| 7 | Evaluating land administration systems: A comparative method with an application to Peru and Honduras显示文摘 | Pablo B Jose M S Cesar F | 2010 | Land Use Policy2010，27，2： | 1 |
| 8 | Electronic nose and SPME techniques to monitor phenanthrene biodegradation in soil 显示文摘 | De Cesare F Pantalei S Zampetti E | 2008 | Sensors and Actuators B: Chemical2008，131，1： | 1 |
| 9 | Isolation of amniotic stem cell lines with potential for therapy 显示文摘 | Paolo D C Georg B Minhaj S Tao X Cesar C S Laura P Gustavo M Angeline C S Evan Y S James J Y Mark E F Shay S and Anthony A | 2007 | Nature Biotectmology2007，25，1： | 1 |
| 10 | Direct Compar-ison of the Bond Strength Results of the DifferentTest Methods: a Critical Literature Review 显示文摘 | Scherrer S S Cesar P F Swain M V | 2010 | Dental Materials2010，26，2： | 1 |
| 11 | Expression of bel-2 oncoprotein benign and malignant spinclle cell tumors of soft tissue.skin,serosal surfaces,and gastrointestinal tract显示文摘 | Saul S Cyril F Cesar M | | 0，，： | 1 |
| 12 | Cruising in the Mediterranean: structural aspects and evolutionary trends 显示文摘 | SORIANI S BETI'AZZON S DI CESARE F | 2009 | Maritime Policy and Management2009，36，3： | 1 |
| 13 | 查看详情显示文摘 | Sun Y Chen X Q Li D Z Cesare F Yunoki S Li Y Y Sun Z F | | 0，，： | 1 |
| 14 | Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides显示文摘 | Claudia R G Cesar A S Ana M F | 2005 | J Pha Sci2005，94，5： | 1 |
| 15 | Amfenac increases the radiosensitivity of uveal melanoma cell lines显示文摘 | Fernandes B F Marshall J C Cesare S D | 2008 | Eye2008，22，5： | 1 |
| 16 | Classification of oat and groat kernels using NIR hypcrspectral imaging显示文摘 | Serranti S Cesare D Marini F | 2013 | Talanta2013，103，： | 1 |
| 17 | Cruising in the Mediterranean: Structural aspects and evolutionary trends 显示文摘 | SORIANI S BERTAZZON S CESARE F | 2009 | Maritime Policy and Management2009，36，3： | 1 |
| 18 | Dynamic system identification and model-based fault diagnosis of an industral gas turbine protoype 显示文摘 | SILVIO S CESARE F | 2006 | Mechatronics2006，16，6： | 1 |
| 19 | Effect of thyroid function on LDL oxidation 显示文摘 | COSTANTINI F PIERDOMENICO S D CESARE D D | 1998 | Arterioscler Thromb Vase Biol1998，18，： | 1 |
| 20 | Production and properties of starch phosphates produced by extrusion processs显示文摘 | ELISABETE S CESAR F C | 1990 | Starch1990，42，15： | 1 |
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