| 2 | Advances in Researches about Immunoregulatory Functions of Dendrobium Sw.显示文摘Based on the researches on immunoregulatory functions of Dendrobium. at home and abroad in recent years,from immune organs,immune cells,and immune molecules,this paper summarized immunoregulatory functions of polysaccharides,glycosides,and alkaloids extracted from Dendrobium. on the body,including reducing the inflammation,inhibiting tumor,and slowing down aging,to provide theoretical references for in-depth researches and development of modern biotechnology for Dendrobium. | Donghui WANG Bei FAN Fang FANG Yan WANG Cencan XING Lijing ZHANG Fengzhong WANG | 2018 | Medicinal Plant2018，9，2： | 0 |
| 3 | TGFβ1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway显示文摘The zebrafish sensory posterior lateral line(pLL)has become an attractive model for studying collective cell migration and cell morphogenesis.Recent studies have indicated that chemokine,Wnt/β-catenin,Fgf,and Delta-Notch signaling pathways participate in regulating pLL development.However,it remains unclear whether TGFβsignaling pathway is involved in pLL development.Here we report a critical role of TGFβ1 in regulating morphogenesis of the pLL primordium(pLLP).The tgfβ1a gene is abundantly expressed in the lateral line primordium.Knockdown or knockout of tgfβ1a leads to a reduction of neuromast number,an increase of inter-neuromast distance,and a reduced number of hair cells.The aberrant morphogenesis in embryos depleted of tgfβ1a correlates with the reduced expression of atoh1a,deltaA,and n-cadherin/cdh2,which are known important regulators of the pLLP morphogenesis.Like tgfβ1a depletion,knockdown of smad5 that expresses in the pLLP,affects pLLP development whereas overexpression of a constitutive active Smad5 isoform rescues the defects in embryos depleted of tgfβ1a,indicating that Smad5 mediates tgfβ1a function in pLLP development.Therefore,TGFβ/Smad5 signaling plays an important role in the zebrafish lateral line formation. | Cencan Xing Bo Gong Yu Xue Yanchao Han Yixia Wang Anming Meng Shunji Jia | 2015 | Journal of Molecular Cell Biology2015，7，1： | 0 |
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