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| 1 | Outcome of patients with acute, necrotizing pancreatitis requiring drainage-does drainage size matter?显示文摘AIM:To assess the outcome of patients with acute necrotizing pancreatitis treated by percutaneous drainage with special focus on the influence of drainage size and number. METHODS:We performed a retrospective analysis of 80 patients with acute pancreatitis requiring percutaneous drainage therapy for infected necroses. Endpoints were mortality and length of hospital stay. The influence of drainage characteristics such as the median drainage size, the largest drainage size per patient and the total drainage plane per patient on patient outcome was evaluated. RESULTS:Total hospital survival was 66%. Thirty-four patients out of all 80 patients (43%) survived acute necrotizing pancreatitis with percutaneous drainage therapy only. Eighteen patients out of all 80 patients needed additional percutaneous necrosectomy (23%). Ten out of these patients required surgical necrosectomy in addition, 6 patients received open necrosectomy without prior percutaneous necrosectomy. Elective surgery was performed in 3 patients receiving cholecystectomy and one patient receiving resection of the parathyroid gland. The number of drainages ranged from one to fourteen per patient. The drainage diameter ranged from 8 French catheters to 24 French catheters. The median drainage size as well as the largest drainage size used per patient and the total drainage area used per patient did not show statistically significant influence on mortality. CONCLUSION:Percutaneous drainage therapy is an effective tool for treatment of necrotizing pancreatitis.Large bore drainages did not prove to be more effective in controlling the septic focus. | T Bruennler J Langgartner S Lang CE Wrede F Klebl S Zierhut S Siebig F Mandraka F Rockmann B Salzberger S Feuerbach J Schoelmerich OW Hamer | 2008 | World Journal of Gastroenterology2008，14，5： | 23 |
| 2 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 3 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 4 | NO modulates P - seloctin and ICAM - 1 mRNA expression of and hemodynamic alterations in hepatic I/R 显示文摘 | Liu P Xu B Hock CE | 1998 | Am J Physiol1998，，275： | 1 |
| 5 | Antigenic diversity of the glyeoprotein and nueleocapsid proteins of rabies and rabiesrelated virus: implication for epidemiology, and control of rabies 显示文摘 | Dietzsehold B Ruppreeht CE Tollis M | 1988 | Reviews of infectious diseases1988，10，： | 1 |
| 6 | The primary-secondary care interlace: does provision of more services in primary care reduce referrals to medical specialists?显示文摘 | van Oijk CE KorevaarJC Koopmans B | 2014 | Health Policy2014，118，： | 1 |
| 7 | Free radicals,antioxidants,and human disease:where are we now显示文摘 | Halliwell B Gutteridge JM Cross CE | 1992 | J Clin Lab Med1992，119，： | 1 |
| 8 | Problems with p53 immonohisto-chemical staining :the effect of fixation and variation in the methods of evacuation显示文摘 | Fisher CJ Cillett CE Voiesek B | 1994 | Br J Cancer1994，69，3： | 1 |
| 9 | In vitro culture of endometrial stromal and gland cells as a model for endometriosis:the effect of peritoneal fluid on proliferation显示文摘 | Overton CE Fernandez-Shaw S Hicks B | 1997 | Fertil Steril1997，67，1： | 1 |
| 10 | Risk factor analysis in differentiated thyroid cancer显示文摘 | Cady B Sedgcoick CE Meissner WA | 1979 | Cancer1979，43，： | 1 |
| 11 | Characterization of a large gene family in Schistosoma japonicum that encodes an immunogenic miracidial antigen显示文摘 | Scallon B J Bogitsh B J Carter CE | 1989 | Mol Biochem Parasitol1989，33，22： | 1 |
| 12 | Do patients with osteogenesis imperfecta need individualized nutritional support? 显示文摘 | Chagas CE Roque JP Santarosa Emo Peters B | 2012 | Nutrition2012，28，2： | 1 |
| 13 | The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chron- ic obstructive pulmonary disease 显示文摘 | Ce|li B R Cote C G Marin J M | 2004 | N Engl J Med2004，350，10： | 1 |
| 14 | Effects of LAR and PTP-BL phosphatase deficiency on adult mouse retinal cells activated by lens injury显示文摘 | Lorber B Hendriks WJ van der Zee CE | 2005 | Eur J Neurosci2005，21，9： | 1 |
| 15 | Pathology of human diabetic nephrop- athy 显示文摘 | biajafian B Alpers CE Fogo AB | 2011 | Contrib Nephrol2011，170，： | 1 |
| 16 | Role of Rho-kinase in mediating contraction of chicken embryo femoral arteries 显示文摘 | Zoer B Blanco CE Villamor E | 2010 | J Comp Physiol B2010，180，3： | 1 |
| 17 | Mast cell/MDSC a liaison immuno- suppressive for tumor microenvironment 显示文摘 | Danelli L Frossi B Pucillo CE | 2015 | Oncoimmunology2015，4，10： | 1 |
| 18 | Solitary renal al- lografts from pediatric cadaver donors less than 2 years of age trans- planted into adult recipients 显示文摘 | Borboroglu PG Foster CE 3rd Philosophe B | 2004 | Transplantation2004，77，5： | 1 |
| 19 | Creation of tissue engineered testcular prosthesis显示文摘 | Yoo JJ Kim B | 2000 | J Urol2000，，： | 1 |
| 20 | Laparoscopic repair of bilateral and recurrent hernias显示文摘 | Frankum CE Ramshaw B J White J | 1999 | Am Surg1999，65，2： | 1 |
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