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| 1 | Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis显示文摘In nature,plants acquire nutrients from soils to sustain growth,and at the same time,they need to avoid the uptake of toxic compounds and/or possess tolerance systems to cope with them.This is particularly challenging when the toxic compound and the nutrient are chemically similar,as in the case of phosphate and arsenate.In this study,we demonstrated that regulatory elements of the phosphate starvation response(PSR)coordinate the arsenate detoxification machinery in the cell.We showed that arsenate repression of the phosphate transporter PHT1;1 is associated with the degradation of the PSR master regulator PHR1.Once arsenic is sequestered into the vacuole,PHR1 stability is restored and PHT1;1 expression is recovered.Furthermore,we identified an arsenite responsive SKP1-like protein and a PHR1 interactor F-box(PHIF1)as constituents of the SCF complex responsible for PHR1 degradation.We found that arsenite,the form to which arsenate is reduced for compartmentalization in vacuoles,represses PHT1;1 expression,providing a highly selective signal versus phosphate to control PHT1;1 expression in response to arsenate.Collectively,our results provide molecular insights into a sensing mechanism that regulates arsenate/phosphate uptake depending on the plant’s detoxification capacity. | Cristina Navarro Cristian Mateo-Elizalde Thotegowdanapalya C.Mohan Eduardo Sanchez-Bermejo Oscar Urrutia Maria Nieves Fernandez-Muniz Jose M.Garcia-Mina Riansares Munoz Javier Paz-Ares Gabriel Castrillo Antonio Leyva | 2021 | Molecular Plant2021，14，9： | 3 |
| 2 | An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair显示文摘The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral repair.Both the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand rabbits.Thus,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the defects.Although both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline cartilage.In conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis. | Filippo Cipriani Blanca Arino Palao Israel Gonzalez de Torre Aurelio Vega Castrillo Hector Jose Aguado Hernandez Matilde Alonso Rodrigo Angel Jose Alvarez Barcia Ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena Jose Carlos Rodriguez-Cabello | 2019 | Regenerative Biomaterials2019，6，6： | 3 |
| 3 | Licensing of university innovations: The role of a technology transfer office 显示文摘 | MACHO - STADLER 1 P? REZ - CASTRILLO D VEUGELERS R | 2007 | International Journal of Industrial Organization2007，25，： | 1 |
| 4 | Reciprocal regulation of inflammation and lipid metabolism by liver X receptors显示文摘 | Castrillo A Laffitte BA | 2003 | Nat Med2003，9，2： | 1 |
| 5 | Sucrose metabolism in mango fruit during ripening显示文摘 | CASTRILLO M KRUGER N J WHATLEY F R | 1992 | Plant science1992，84，1： | 1 |
| 6 | Evaluation of theinternational index in the prognosis of high grade gastric malt lymphoma显示文摘 | Castrillo JM Montalbdn C Abraira V | 1996 | Leuk Lymphoma1996，24，12： | 1 |
| 7 | Specific leaf mass, fresh: dry weight ratio, sugar and protein contents in species of Lamiaceae from different light environments显示文摘 | CASTRILLO M VIZCAINO D MORENO E | 2005 | Revista de Biologia Tropical2005，53，2： | 1 |
| 8 | Action of 3 methylquercetin on poliovirus RNA replication显示文摘 | Castrillo J L Carrasco L | 1987 | J Viro1987，61，10： | 1 |
| 9 | Action of 3-methyl quercetin on poliovirus RNA replication显示文摘 | Castrillo JL Carrasco L | 1987 | J Virol1987，61，10： | 1 |
| 10 | Reciprocal regula- tion of inflammation and lipid metabolism by liver X recep- tors 显示文摘 | Joseph SB Castrillo A Laffitte BA | 2003 | Nat Med2003，9，2： | 1 |
| 11 | Selective activation of liver X receptors by acanthoic acid-related diterpenes显示文摘 | Traves PG Hortelano S Zeini M Chao TH Lam T Neuteboom ST Theodorakis EA Palladino MA Castrillo A Bosca L | | 0，，06： | 1 |
| 12 | Licensing of university in- ventions: The role of a technology transfer office显示文摘 | Macho --- Stadler I P-rez -- Castrillo D Veugelers R | 2007 | International Journal of Indus- trial Organization2007，25，3： | 1 |
| 13 | The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein显示文摘 | BODNER M CASTRILLO J L THEILL L E | 1988 | Cell1988，55，3： | 1 |
| 14 | Reciprocal regulation of inflammation and lipid metabolism by liver X receptors 显示文摘 | Joseph SB Castrillo A Laffitte BA | 2003 | Nature Medicine2003，9，2： | 1 |
| 15 | Reciprocal regulation of inflammation and lipid metabolism by liver X receptors显示文摘 | Joseph SB Castrillo A Laffitte BA | 2003 | Nature Medicine2003，9，2： | 1 |
| 16 | Nuclear receptors in macrophage biology : at the crossroads of lipid metabolism and inflammation 显示文摘 | CASTRILLO A TONTONOZ P | 2004 | Ann Rev Cell Dev Biol2004，20，： | 1 |
| 17 | Gastric B-cell mucosa-associated lymphoid tissue ( MALT ) lymphoma:clinicopathological study and evaluation of prognostic factors in 143 patients显示文摘 | Castrillo JM Abraira V | 1995 | Ann Oncol1995，6，4： | 1 |
| 18 | Effect of ammonia treat and carbohydrate supplementation on the intake and digestibility of barley straw diets by sheep显示文摘 | Castrillo C Fondevila M Guada J A | 1995 | Anim Feed Sci Technol1995，51，： | 1 |
| 19 | Induction of NR4A orphan nuclear receptor expression in maerophages in response to inflammatory stimuli 显示文摘 | Pei L Castrillo A Chen M | 2005 | J Biol Chem2005，280，29： | 1 |
| 20 | Reciprocal regulation of inflammation and lipid metabolism by liver X receptors显示文摘 | Joseph SB Castrillo A Laffitte BA | 2003 | Nat Med2003，9，2： | 1 |
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