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| 1 | Global secretome analysis identifies novel mediators of bone metastasis显示文摘骨头是稳固的肿瘤的远转移的一个最普通的地点。分泌蛋白质被知道影响在变形癌症房间和骨头基质之间的病理学的相互作用。为了包括地介绍,分泌了与骨头转移联系的蛋白质,我们使用了量、非量的集体 spectrometry 全球性分析改变从多重种类和癌症的变形能力打的骨头的九根细胞线的 secretomes。由比较父母房间和他们的骨头的 secretomes 变形衍生物,我们识别了特别地在这些房间线与骨头转移被联系的分泌蛋白质。我们然后合并了大临床的转移数据集的生物信息的分析获得强烈与临床、试验性的骨头转移被联系的几个功能的班的候选人小说骨头转移蛋白质的一张表。选择蛋白质的功能的确认显示在 vivo,骨头转移能被高表示支持(1 ) 唾液的 cystatins CST1, CST2,和 CST4;(2 ) plasminogen 使活跃之物小块地和 PLAU;或(3 ) 骨胶原功能蛋白质 PLOD2 和 COL6A1。总的来说,我们的学习揭开了骨头转移并且因此的几个新分泌调停人证明 secretome 分析是为新奇 biomarkers 和候选人的鉴定的一个强大的方法治疗学的目标。 | Maria Andres Blanco Gary LeRoy Zia Khan Ma a Ale kovi Barry M Zee Benjamin A Garcia Yibin Kang | 2012 | Cell Research2012，22，9： | 12 |
| 2 | Blood pressure gradients in cerebral arteries:a clue to pathogenesis of cerebral small vessel disease显示文摘rationale The role of hypertension in cerebral small vessel disease is poorly understood.At the base of the brain(the‘vascular centrencephalon’),short straight arteries transmit blood pressure directly to small resistance vessels;the cerebral convexity is supplied by long arteries with many branches,resulting in a drop in blood pressure.Hypertensive small vessel disease(lipohyalinosis)causes the classically described lacunar infarctions at the base of the brain;however,periventricular white matter intensities(WMIs)seen on MRI and WMI in subcortical areas over the convexity,which are often also called‘lacunes’,probably have different aetiologies.Objectives We studied pressure gradients from proximal to distal regions of the cerebral vasculature by mathematical modelling.Methods and results Blood flow/pressure equations were solved in an Anatomically Detailed Arterial Network(ADAN)model,considering a normotensive and a hypertensive case.Model parameters were suitably modified to account for structural changes in arterial vessels in the hypertensive scenario.Computations predict a marked drop in blood pressure from large and medium-sized cerebral vessels to cerebral peripheral beds.When blood pressure in the brachial artery is 192/113 mm Hg,the pressure in the small arterioles of the posterior parietal artery bed would be only 117/68 mm Hg.In the normotensive case,with blood pressure in the brachial artery of 117/75 mm Hg,the pressure in small parietal arterioles would be only 59/38 mm Hg.conclusion These findings have important implications for understanding small vessel disease.The marked pressure gradient across cerebral arteries should be taken into account when evaluating the pathogenesis of small WMIs on MRI.Hypertensive small vessel disease,affecting the arterioles at the base of the brain should be distinguished from small vessel disease in subcortical regions of the convexity and venous disease in the periventricular white matter. | Pablo J Blanco Lucas O Müller J David Spence | 2017 | Stroke & Vascular Neurology2017，2，3： | 9 |
| 3 | Clinical significance of'anti-HBc alone'in human immunodeficiency virus-positive patients显示文摘AIM:To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection('anti-HBc alone')among human immunodeficiency virus(HIV) type-1 infected patients.Occult hepatitis B infection frequency was also evaluated. METHODS:Three hundred and forty eight histories from 2388 HIV-positive patients were randomly reviewed.Patients with serological markers of hepatitis B virus(HBV)infection were classified into three groups:past hepatitis,'anti-HBc alone'and chronic hepatitis.Determination of DNA from HBV,and RNA and genotype from hepatitis C virus(HCV)were performed on'anti-HBc alone'patients. RESULTS:One hundred and eighty seven(53.7%) HIV-positive patients had markers of HBV infection: 118 past infection(63.1%),14 chronic hepatitis (7.5%)and 55'anti-HBc alone'(29.4%).Younger age[2.3-fold higher per every 10 years younger;95% confidence intervals(CI)1.33-4.00]and antibodies to HCV infection[odds ratio(OR)2.87;95%CI 1.10-7.48]were factors independently associated with the'anti-HBc alone'pattern.No differences in liver disease frequency were detected between both groups. Serum levels of anti-HBs were not associated with HCV infection(nor viral replication or HCV genotype),or with HIV replication or CD4 level.No'anti-HBc alone' patient tested positive for HBV DNA. CONCLUSION:'Anti-HBc alone'prevalence in HIVpositive patients was similar to previously reported data and was associated with a younger age and with antibodies to HCV infection.In clinical practice,HBV DNA determination should be performed only in those patients with clinical or analytical signs of liver injury. | M~aTeresa Pérez-Rodríguez Bernardo Sopea Manuel Crespo Alberto Rivera Teresa González del Blanco Antonio Ocampo César Martínez-Vázquez | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 4 | Alkali -activated fly ashes A cement for the future 显示文摘 | PALOMO A GRUTZECK M W BLANCO M T | 1999 | Cem Concr Res1999，29，8： | 2 |
| 5 | Effect of glatiramer acetate (Copaxone) on the immunophenotypic and cytokine profile and BDNF production in muhiple sclerosis : a longitudinal study 显示文摘 | Blanco Y Moral EA Costa M | 2006 | Neurosci Lett2006，406，3： | 1 |
| 6 | Ethanol improves lipase immobilization on a hydrophobic support 显示文摘 | BLANCO R M TERREROS P MUNOZ N | 2007 | Journal Molecular Catalysis B: Enzymatic2007，47，12： | 1 |
| 7 | Combined DNA immunization with the glycoprotein gene of viral hemorrhagic septicemia virus and infectious hematopoietic necrosis virus induces double-specific protective immunity and nonspecific response in rainbow trout显示文摘 | Blanco M de Kinkelin P | 1998 | Virology1998，249，2： | 1 |
| 8 | Neurologic complications of type Ⅰ aortic dissection显示文摘 | Blanco M Diez-Tejedor E Larrea JL | 1999 | Acta Neurol Scand1999，99，4： | 1 |
| 9 | Long-term results and survival rate of implants treated with guided bone regeneration: a 5-year case series prospective study显示文摘 | Blanco J Alonso A Sanz M | 2005 | Clin Oral hnplants Res2005，16，3： | 1 |
| 10 | Microemulsion Dynamics and Reactions in Microemulsions显示文摘 | M A Lo'pez-Quimela C Tojo M C Blanco | 2004 | Current Opinion in Colloid and Interface Science2004，9，34： | 1 |
| 11 | Proteomic characterization of human normal articular chondrocytes: a novel tool for the study of osteoarthritis and other rheumatic diseases显示文摘 | Ruiz-Romero C Lopez-Armada M J Blanco FJ | 2005 | Proteomics2005，5，12： | 1 |
| 12 | The release of tumor necrosis factor-alpha is associated with ische mic tolerance in human stroke显示文摘 | Castillo J Moro MA Blanco M | 2003 | Ann Neurol2003，54，6： | 1 |
| 13 | The release of tumor necrosis factor-alpha is associated with ischemic tolerance in human stroke显示文摘 | Castillo J Moro MA Blanco M | 2003 | Ann Neurol2003，54，6： | 1 |
| 14 | Molybdophoric acid adsorption on titania from ethanol-water solutions显示文摘 | CONCELLON A VAZQUEZ P BLANCO M | 1998 | Colloid and Inter Sci1998，204，2： | 1 |
| 15 | Characterization and analysis of polymorphs by near-infrared spectrometry 显示文摘 | Blanco M Valdes D Bayod MS | 2004 | Analytica Chimica Acta2004，502，2： | 1 |
| 16 | System for eleavable Fc fusion proteins using tobacco etch virus (TEV) protease 显示文摘 | Haspel J Blanco C Jacob J Grumet M | 2001 | Biotechniques2001，30，1： | 1 |
| 17 | Development of a PCR assay for Streptococcus iniae based on the lactate oxidase(lctO )gene with potential diagno- sticvalue显示文摘 | I ANA M MATA BLANCO MAR | 2004 | Veterinary Microbiology2004，101，： | 1 |
| 18 | CDP-choline treatment increases circulating endothelial progenitor cells in acute ischemic stroke显示文摘 | Sobrino T Rodriguez-Gonzfilez R Blanco M | 2011 | Neurol Res2011，33，： | 1 |
| 19 | Effect of Moxibustion at Acupoints Ren-12 (Zhongwan),St-25 (Tianshu),and St-36 (Zuzanli) in the Prevention of Gastric Lesions Induced by Indomethacin in Wistar Rats显示文摘 | Freire A O Sugai G C Blanco M M | | 0，，02： | 1 |
| 20 | Subacute combined degeneration of the spinal cord: MR findings显示文摘 | Penas M Blanco A Villarejo A | 2002 | Neurologia2002，17，8： | 1 |
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